6HX3

PDX1.2/PDX1.3 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0042819	biological_process	vitamin B6 biosynthetic process
A	0042823	biological_process	pyridoxal phosphate biosynthetic process
A	0046982	molecular_function	protein heterodimerization activity
B	0042819	biological_process	vitamin B6 biosynthetic process
B	0042823	biological_process	pyridoxal phosphate biosynthetic process
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0042819	biological_process	vitamin B6 biosynthetic process
C	0042823	biological_process	pyridoxal phosphate biosynthetic process
C	0046982	molecular_function	protein heterodimerization activity
D	0042819	biological_process	vitamin B6 biosynthetic process
D	0042823	biological_process	pyridoxal phosphate biosynthetic process
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0042819	biological_process	vitamin B6 biosynthetic process
E	0042823	biological_process	pyridoxal phosphate biosynthetic process
E	0046982	molecular_function	protein heterodimerization activity
F	0042819	biological_process	vitamin B6 biosynthetic process
F	0042823	biological_process	pyridoxal phosphate biosynthetic process
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0042819	biological_process	vitamin B6 biosynthetic process
G	0042823	biological_process	pyridoxal phosphate biosynthetic process
G	0046982	molecular_function	protein heterodimerization activity
H	0042819	biological_process	vitamin B6 biosynthetic process
H	0042823	biological_process	pyridoxal phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue SO4 A 401

Chain	Residue
A	PHE135
D	LYS203
D	HOH416
A	GLU154
A	ARG157
A	ARG158
B	HIS131
B	GLU150
B	ARG153
B	ARG154
C	LYS208

---

site_id	AC2
Number of Residues	9
Details	binding site for residue SO4 C 401

Chain	Residue
A	LYS208
A	HOH531
B	LYS203
C	PHE135
C	ARG157
C	ARG158
D	HIS131
D	ARG153
D	ARG154

---

site_id	AC3
Number of Residues	9
Details	binding site for residue SO4 C 402

Chain	Residue
C	GLU48
C	THR173
C	GLY235
C	GLY256
D	GLU167
D	ALA168
D	GLY169
D	GLY230
D	GLY251

---

site_id	AC4
Number of Residues	10
Details	binding site for residue SO4 E 401

Chain	Residue
E	PHE135
E	GLU154
E	ARG157
E	ARG158
E	HOH505
F	GLU150
F	ARG153
F	ARG154
G	LYS208
H	LYS203

---

site_id	AC5
Number of Residues	10
Details	binding site for residue SO4 G 401

Chain	Residue
E	LYS208
E	HOH524
F	LYS203
G	PHE135
G	ARG157
G	ARG158
H	HIS131
H	GLU150
H	ARG153
H	ARG154

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 B 301

Chain	Residue
A	ILE127
A	SER128
A	VAL129
B	LEU123
B	THR124
B	LEU125
B	HOH402

---

site_id	AC7
Number of Residues	12
Details	binding site for residue SO4 B 302

Chain	Residue
A	THR173
A	GLY234
A	GLY235
A	GLY256
A	HOH508
B	LYS165
B	GLU167
B	ALA168
B	GLY169
B	GLY229
B	GLY230
B	GLY251

---

site_id	AC8
Number of Residues	6
Details	binding site for residue SO4 D 301

Chain	Residue
C	ILE127
C	VAL129
D	LEU123
D	THR124
D	LEU125
D	HOH404

---

site_id	AC9
Number of Residues	7
Details	binding site for residue SO4 F 301

Chain	Residue
E	ILE127
E	SER128
E	VAL129
F	LEU123
F	THR124
F	LEU125
F	HOH410

---

site_id	AD1
Number of Residues	9
Details	binding site for residue SO4 F 302

Chain	Residue
E	GLU48
E	THR173
E	GLY235
E	GLY256
F	GLU167
F	ALA168
F	GLY169
F	GLY230
F	GLY251

---

site_id	AD2
Number of Residues	8
Details	binding site for residue SO4 H 301

Chain	Residue
G	ILE127
G	SER128
G	VAL129
H	LEU123
H	THR124
H	LEU125
H	HOH406
H	HOH420

---

site_id	AD3
Number of Residues	10
Details	binding site for residue SO4 H 302

Chain	Residue
G	GLY234
G	GLY235
G	GLY256
H	GLU167
H	ALA168
H	GLY169
H	GLY229
H	GLY230
H	GLY251
G	ASP171

---

Functional Information from PROSITE/UniProt

site_id	PS01235
Number of Residues	19
Details	PDXS_SNZ_1 PdxS/SNZ family signature. VPVVQFASGGITTPADAAL

Chain	Residue	Details
A	VAL226-LEU244
B	LEU221-LEU239

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Schiff-base intermediate with D-ribose 5-phosphate => ECO:0000250|UniProtKB:O59080

Chain	Residue	Details
B	LYS97
D	LYS97
F	LYS97
H	LYS97

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250|UniProtKB:O59080

Chain	Residue	Details
B	ASP40
F	GLY169
F	GLY230
F	GLY251
H	ASP40
H	GLY169
H	GLY230
H	GLY251
B	GLY169
B	GLY230
B	GLY251
D	ASP40
D	GLY169
D	GLY230
D	GLY251
F	ASP40

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q03148

Chain	Residue	Details
B	ARG181
D	ARG181
F	ARG181
H	ARG181

---