6HUY

HmdII from Desulfurobacterium thermolithotrophum reconstitued with Fe-guanylylpyridinol (FeGP) cofactor and co-crystallized with methenyl-tetrahydrofolate form A

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	binding site for residue FE9 A 401

Chain	Residue
A	TYR6
A	PHE88
A	THR89
A	PRO90
A	VAL95
A	ILE99
A	THR116
A	CYS117
A	THR118
A	HIS146
A	PRO147
A	PHE8
A	ALA149
A	ILE150
A	PRO151
A	GUE403
A	HOH565
A	HOH575
A	GLY9
A	SER10
A	TYR14
A	SER49
A	ASP50
A	PRO51
A	ASP75

---

site_id	AC2
Number of Residues	8
Details	binding site for residue GOL A 402

Chain	Residue
A	GLU138
A	ILE140
A	PRO170
A	ILE171
A	VAL172
A	THR173
A	HOH537
A	HOH562

---

site_id	AC3
Number of Residues	17
Details	binding site for residue GUE A 403

Chain	Residue
A	TYR13
A	LYS17
A	PHE91
A	ARG92
A	ALA148
A	GLY203
A	ASP204
A	MET205
A	FE9401
A	HOH561
A	HOH575
B	LYS229
B	THR230
B	MET234
B	SER270
B	SER273
B	MET274

---

site_id	AC4
Number of Residues	5
Details	binding site for residue DMS B 401

Chain	Residue
B	GLY9
B	SER10
B	LEU11
B	ASN52
B	LYS55

---

site_id	AC5
Number of Residues	2
Details	binding site for residue DMS B 402

Chain	Residue
B	SER10
B	TYR14

---

site_id	AC6
Number of Residues	5
Details	binding site for residue DMS B 403

Chain	Residue
B	GLU138
B	VAL172
B	THR173
B	HOH511
B	HOH656

---

site_id	AC7
Number of Residues	5
Details	binding site for residue DMS B 404

Chain	Residue
B	ILE53
B	ASP54
B	ARG61
B	LEU71
B	HOH521

---

site_id	AC8
Number of Residues	2
Details	binding site for residue PG4 B 405

Chain	Residue
B	LEU134
B	GLU135

---

site_id	AC9
Number of Residues	19
Details	binding site for residue GUE B 406

Chain	Residue
A	THR230
A	MET234
A	SER270
A	SER273
A	MET274
B	TYR13
B	PRO90
B	PHE91
B	ARG92
B	CSO117
B	THR118
B	ALA148
B	ILE150
B	GLY203
B	ASP204
B	MET205
B	HOH509
B	HOH514
B	HOH552

---

site_id	AD1
Number of Residues	27
Details	binding site for residue FE9 C 401

Chain	Residue
C	PRO90
C	VAL95
C	ILE99
C	THR116
C	CYS117
C	THR118
C	HIS146
C	PRO147
C	ALA148
C	ALA149
C	ILE150
C	PRO151
C	GUE404
C	HOH521
C	HOH529
C	HOH533
C	TYR6
C	PHE8
C	GLY9
C	SER10
C	TYR14
C	SER49
C	ASP50
C	PRO51
C	ASP75
C	PHE88
C	THR89

---

site_id	AD2
Number of Residues	4
Details	binding site for residue DMS C 402

Chain	Residue
C	GLU138
C	ASP139
C	ILE140
C	ILE171

---

site_id	AD3
Number of Residues	5
Details	binding site for residue DMS C 403

Chain	Residue
C	LEU166
C	LEU167
D	PRO310
D	GLU312
D	PRO313

---

site_id	AD4
Number of Residues	17
Details	binding site for residue GUE C 404

Chain	Residue
C	TYR13
C	LYS17
C	PHE91
C	ARG92
C	ALA148
C	GLY203
C	ASP204
C	MET205
C	FE9401
C	HOH521
C	HOH575
C	HOH602
D	THR230
D	MET234
D	SER270
D	SER273
D	MET274

---

site_id	AD5
Number of Residues	3
Details	binding site for residue GOL D 401

Chain	Residue
D	ALA40
D	LYS41
D	ALA67

---

site_id	AD6
Number of Residues	4
Details	binding site for residue DMS D 402

Chain	Residue
D	GLY9
D	SER10
D	LEU11
D	ASN52

---

site_id	AD7
Number of Residues	2
Details	binding site for residue DMS D 403

Chain	Residue
D	SER10
D	TYR14

---

site_id	AD8
Number of Residues	4
Details	binding site for residue DMS D 404

Chain	Residue
D	GLU138
D	PRO170
D	ILE171
D	VAL172

---

site_id	AD9
Number of Residues	19
Details	binding site for residue GUE D 405

Chain	Residue
C	THR230
C	MET234
C	SER270
C	SER273
C	MET274
D	TYR13
D	PRO90
D	PHE91
D	ARG92
D	CSO117
D	THR118
D	ALA148
D	ILE150
D	GLY203
D	ASP204
D	MET205
D	HOH502
D	HOH541
D	HOH547

---