Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HUF

Coping with strong translational non-crystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
E	0003924	molecular_function	GTPase activity
E	0005525	molecular_function	GTP binding
F	0003924	molecular_function	GTPase activity
F	0005525	molecular_function	GTP binding
G	0003924	molecular_function	GTPase activity
G	0005525	molecular_function	GTP binding
H	0003924	molecular_function	GTPase activity
H	0005525	molecular_function	GTP binding
I	0003924	molecular_function	GTPase activity
I	0005525	molecular_function	GTP binding
J	0003924	molecular_function	GTPase activity
J	0005525	molecular_function	GTP binding
K	0003924	molecular_function	GTPase activity
K	0005525	molecular_function	GTP binding
L	0003924	molecular_function	GTPase activity
L	0005525	molecular_function	GTP binding
M	0003924	molecular_function	GTPase activity
M	0005525	molecular_function	GTP binding
N	0003924	molecular_function	GTPase activity
N	0005525	molecular_function	GTP binding
O	0003924	molecular_function	GTPase activity
O	0005525	molecular_function	GTP binding
P	0003924	molecular_function	GTPase activity
P	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 201

Chain	Residue
A	THR23
A	THR41
A	GNP202
A	HOH301

site_id	AC2
Number of Residues	22
Details	binding site for residue GNP A 202

Chain	Residue
A	LYS22
A	THR23
A	SER24
A	PHE34
A	SER36
A	PHE38
A	THR40
A	THR41
A	GLY67
A	ASN123
A	LYS124
A	ASP126
A	LEU127
A	SER153
A	ALA154
A	MG201
A	HOH301
A	ASP17
A	SER18
A	GLY19
A	VAL20
A	GLY21

site_id	AC3
Number of Residues	3
Details	binding site for residue MG O 201

Chain	Residue
O	THR23
O	THR41
O	GNP202

site_id	AC4
Number of Residues	21
Details	binding site for residue GNP O 202

Chain	Residue
O	ASP17
O	SER18
O	GLY19
O	VAL20
O	GLY21
O	LYS22
O	THR23
O	SER24
O	PHE34
O	SER36
O	PHE38
O	THR40
O	THR41
O	GLY67
O	ASN123
O	LYS124
O	ASP126
O	LEU127
O	SER153
O	ALA154
O	MG201

site_id	AC5
Number of Residues	4
Details	binding site for residue MG N 201

Chain	Residue
N	THR23
N	THR41
N	ASP64
N	GNP202

site_id	AC6
Number of Residues	19
Details	binding site for residue GNP N 202

Chain	Residue
N	ASP17
N	SER18
N	GLY19
N	VAL20
N	GLY21
N	LYS22
N	THR23
N	SER24
N	SER36
N	THR40
N	THR41
N	GLY67
N	ASN123
N	LYS124
N	ASP126
N	LEU127
N	SER153
N	ALA154
N	MG201

site_id	AC7
Number of Residues	3
Details	binding site for residue MG B 201

Chain	Residue
B	THR23
B	THR41
B	GNP202

site_id	AC8
Number of Residues	21
Details	binding site for residue GNP B 202

Chain	Residue
B	ASP17
B	SER18
B	GLY19
B	VAL20
B	GLY21
B	LYS22
B	THR23
B	SER24
B	SER36
B	PHE38
B	THR40
B	THR41
B	THR65
B	GLY67
B	ASN123
B	LYS124
B	ASP126
B	LEU127
B	SER153
B	ALA154
B	MG201

site_id	AC9
Number of Residues	3
Details	binding site for residue MG E 201

Chain	Residue
E	GNP202
E	THR23
E	THR41

site_id	AD1
Number of Residues	21
Details	binding site for residue GNP E 202

Chain	Residue
E	ASP17
E	SER18
E	GLY19
E	VAL20
E	GLY21
E	LYS22
E	THR23
E	SER24
E	SER36
E	PHE38
E	THR40
E	THR41
E	GLY67
E	ASN123
E	LYS124
E	ASP126
E	LEU127
E	SER153
E	ALA154
E	ALA155
E	MG201

site_id	AD2
Number of Residues	4
Details	binding site for residue MG C 201

Chain	Residue
C	THR23
C	THR41
C	ASP64
C	GNP202

site_id	AD3
Number of Residues	22
Details	binding site for residue GNP C 202

Chain	Residue
C	ASP17
C	SER18
C	GLY19
C	VAL20
C	GLY21
C	LYS22
C	THR23
C	SER24
C	PHE34
C	SER36
C	PHE38
C	THR40
C	THR41
C	THR65
C	GLY67
C	ASN123
C	LYS124
C	ASP126
C	SER153
C	ALA154
C	ALA155
C	MG201

site_id	AD4
Number of Residues	4
Details	binding site for residue MG K 201

Chain	Residue
K	THR23
K	THR41
K	ASP64
K	GNP202

site_id	AD5
Number of Residues	18
Details	binding site for residue GNP K 202

Chain	Residue
K	ASP17
K	SER18
K	GLY19
K	GLY21
K	LYS22
K	THR23
K	SER24
K	SER36
K	THR40
K	THR41
K	GLY67
K	ASN123
K	LYS124
K	ASP126
K	LEU127
K	SER153
K	ALA154
K	MG201

site_id	AD6
Number of Residues	4
Details	binding site for residue MG M 201

Chain	Residue
M	THR23
M	THR41
M	ASP64
M	GNP202

site_id	AD7
Number of Residues	20
Details	binding site for residue GNP M 202

Chain	Residue
M	ASP17
M	SER18
M	GLY19
M	VAL20
M	GLY21
M	LYS22
M	THR23
M	SER24
M	PHE34
M	SER36
M	PHE38
M	THR41
M	GLY67
M	ASN123
M	LYS124
M	ASP126
M	LEU127
M	SER153
M	ALA154
M	MG201

site_id	AD8
Number of Residues	3
Details	binding site for residue MG D 201

Chain	Residue
D	THR23
D	THR41
D	GNP202

site_id	AD9
Number of Residues	18
Details	binding site for residue GNP D 202

Chain	Residue
D	ASP17
D	SER18
D	GLY19
D	VAL20
D	GLY21
D	LYS22
D	THR23
D	SER24
D	SER36
D	THR40
D	THR41
D	GLY67
D	ASN123
D	LYS124
D	ASP126
D	SER153
D	ALA154
D	MG201

site_id	AE1
Number of Residues	4
Details	binding site for residue MG P 201

Chain	Residue
P	THR23
P	THR41
P	ASP64
P	GNP202

site_id	AE2
Number of Residues	22
Details	binding site for residue GNP P 202

Chain	Residue
P	ASP17
P	SER18
P	GLY19
P	VAL20
P	GLY21
P	LYS22
P	THR23
P	SER24
P	PHE34
P	SER36
P	THR40
P	THR41
P	THR65
P	GLY67
P	ASN123
P	LYS124
P	ASP126
P	LEU127
P	SER153
P	ALA154
P	ALA155
P	MG201

site_id	AE3
Number of Residues	3
Details	binding site for residue MG F 201

Chain	Residue
F	THR23
F	THR41
F	GNP202

site_id	AE4
Number of Residues	19
Details	binding site for residue GNP F 202

Chain	Residue
F	ASP17
F	SER18
F	GLY19
F	GLY21
F	LYS22
F	THR23
F	SER24
F	SER36
F	PHE38
F	THR40
F	THR41
F	GLY67
F	ASN123
F	LYS124
F	ASP126
F	SER153
F	ALA154
F	ALA155
F	MG201

site_id	AE5
Number of Residues	3
Details	binding site for residue MG J 201

Chain	Residue
J	THR23
J	THR41
J	GNP202

site_id	AE6
Number of Residues	19
Details	binding site for residue GNP J 202

Chain	Residue
J	ASP17
J	SER18
J	GLY19
J	VAL20
J	GLY21
J	LYS22
J	THR23
J	SER24
J	PHE34
J	SER36
J	THR41
J	GLY67
J	ASN123
J	LYS124
J	ASP126
J	LEU127
J	SER153
J	ALA154
J	MG201

site_id	AE7
Number of Residues	3
Details	binding site for residue MG G 201

Chain	Residue
G	THR23
G	THR41
G	GNP202

site_id	AE8
Number of Residues	19
Details	binding site for residue GNP G 202

Chain	Residue
G	ASP17
G	SER18
G	GLY19
G	GLY21
G	LYS22
G	THR23
G	SER24
G	SER36
G	THR40
G	THR41
G	THR65
G	GLY67
G	ASN123
G	LYS124
G	ASP126
G	LEU127
G	SER153
G	ALA154
G	MG201

site_id	AE9
Number of Residues	4
Details	binding site for residue MG I 201

Chain	Residue
I	THR23
I	THR41
I	ASP64
I	GNP202

site_id	AF1
Number of Residues	20
Details	binding site for residue GNP I 202

Chain	Residue
I	ASP17
I	SER18
I	GLY19
I	VAL20
I	GLY21
I	LYS22
I	THR23
I	SER24
I	SER36
I	PHE38
I	THR40
I	THR41
I	THR65
I	GLY67
I	ASN123
I	LYS124
I	ASP126
I	SER153
I	ALA154
I	MG201

site_id	AF2
Number of Residues	3
Details	binding site for residue MG H 201

Chain	Residue
H	THR23
H	THR41
H	GNP202

site_id	AF3
Number of Residues	21
Details	binding site for residue GNP H 202

Chain	Residue
H	ASP17
H	SER18
H	GLY19
H	VAL20
H	GLY21
H	LYS22
H	THR23
H	SER24
H	SER36
H	PHE38
H	THR40
H	THR41
H	THR65
H	GLY67
H	ASN123
H	LYS124
H	ASP126
H	LEU127
H	SER153
H	ALA154
H	MG201

site_id	AF4
Number of Residues	3
Details	binding site for residue MG L 201

Chain	Residue
L	THR23
L	THR41
L	GNP202

site_id	AF5
Number of Residues	21
Details	binding site for residue GNP L 202

Chain	Residue
L	ASP17
L	SER18
L	GLY19
L	VAL20
L	GLY21
L	LYS22
L	THR23
L	SER24
L	SER36
L	PHE38
L	THR40
L	THR41
L	THR65
L	GLY67
L	ASN123
L	LYS124
L	ASP126
L	LEU127
L	SER153
L	ALA154
L	MG201

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	128
Details	Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	272
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)