6HT9
Mouse fetuin-B in complex with crayfish astacin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0007338 | biological_process | single fertilization |
| B | 0007339 | biological_process | binding of sperm to zona pellucida |
| B | 0008191 | molecular_function | metalloendopeptidase inhibitor activity |
| B | 0010951 | biological_process | negative regulation of endopeptidase activity |
| B | 0030414 | molecular_function | peptidase inhibitor activity |
| C | 0004222 | molecular_function | metalloendopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008237 | molecular_function | metallopeptidase activity |
| C | 0008270 | molecular_function | zinc ion binding |
| D | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0007338 | biological_process | single fertilization |
| D | 0007339 | biological_process | binding of sperm to zona pellucida |
| D | 0008191 | molecular_function | metalloendopeptidase inhibitor activity |
| D | 0010951 | biological_process | negative regulation of endopeptidase activity |
| D | 0030414 | molecular_function | peptidase inhibitor activity |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TIIHELMHAI |
| Chain | Residue | Details |
| A | THR89-ILE98 |
| site_id | PS01254 |
| Number of Residues | 119 |
| Details | FETUIN_1 Fetuin family signature 1. CNDsevlavagfalqninrdqkdgymlslnrvhdvrehyqedmgslfyltldvletdCHvlsrkaqkdCkprmfyesvygq..CkamfhinkprrvlylpaynCtlrpvskrkthttCpdC |
| Chain | Residue | Details |
| B | CYS39-CYS157 |
| site_id | PS01255 |
| Number of Residues | 10 |
| Details | FETUIN_2 Fetuin family signature 2. DvLETdCHvL |
| Chain | Residue | Details |
| B | ASP90-LEU99 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9UGM5 |
| Chain | Residue | Details |
| B | SER321 | |
| D | SER321 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN40 | |
| D | ASN40 | |
| A | HIS102 | |
| C | HIS92 | |
| C | HIS96 | |
| C | HIS102 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17330941 |
| Chain | Residue | Details |
| B | ASN139 | |
| D | ASN139 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000250|UniProtKB:Q58D62 |
| Chain | Residue | Details |
| B | THR292 | |
| B | THR295 | |
| D | THR292 | |
| D | THR295 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 403 |
| Chain | Residue | Details |
| A | HIS92 | metal ligand |
| A | GLU93 | proton shuttle (general acid/base) |
| A | HIS96 | metal ligand |
| A | HIS102 | metal ligand |
| A | TYR149 | transition state stabiliser |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 403 |
| Chain | Residue | Details |
| C | HIS92 | metal ligand |
| C | GLU93 | proton shuttle (general acid/base) |
| C | HIS96 | metal ligand |
| C | HIS102 | metal ligand |
| C | TYR149 | transition state stabiliser |
