6HT5

Oct4/Sox2:UTF1 structure

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00027
Number of Residues	24
Details	HOMEOBOX_1 'Homeobox' domain signature. IAnqLgLEkdVVRVWFsNrrqkgK

Chain	Residue	Details
E	ILE258-LYS281

---

site_id	PS00035
Number of Residues	13
Details	POU_1 POU-specific (POUs) domain signature 1. KRItLGYtQaDVG

Chain	Residue	Details
E	LYS151-GLY163

---

site_id	PS00465
Number of Residues	14
Details	POU_2 POU-specific (POUs) domain signature 2. SQTTISRFEaLqLS

Chain	Residue	Details
E	SER175-SER188

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	68
Details	DNA binding: {"description":"HMG box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00267","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P48431","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	74
Details	Domain: {"description":"POU-specific","evidences":[{"source":"PROSITE-ProRule","id":"PRU00530","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"23376973","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3L1P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23376973","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3L1P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q01860","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q01860","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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