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6HRH

Structure of human erythroid-specific 5'-aminolevulinate synthase, ALAS2

Functional Information from GO Data
ChainGOidnamespacecontents
A0003870molecular_function5-aminolevulinate synthase activity
A0009058biological_processbiosynthetic process
A0016740molecular_functiontransferase activity
A0030170molecular_functionpyridoxal phosphate binding
A0033014biological_processtetrapyrrole biosynthetic process
B0003870molecular_function5-aminolevulinate synthase activity
B0009058biological_processbiosynthetic process
B0016740molecular_functiontransferase activity
B0030170molecular_functionpyridoxal phosphate binding
B0033014biological_processtetrapyrrole biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue PLP B 601
ChainResidue
ATHR420
BHIS360
BTHR388
BLYS391
BHOH732
ATHR421
BSER257
BCYS258
BPHE259
BHIS285
BGLU328
BSER332
BASP357

site_idAC2
Number of Residues15
Detailsbinding site for residue PLP A 601
ChainResidue
ASER257
ACYS258
APHE259
AASN262
AHIS285
AGLU328
ASER332
AASP357
AHIS360
ATHR388
ALYS391
AHOH731
BPHE419
BTHR420
BTHR421

Functional Information from PROSITE/UniProt
site_idPS00599
Number of Residues10
DetailsAA_TRANSFER_CLASS_2 Aminotransferases class-II pyridoxal-phosphate attachment site. TLGKAFGCVG
ChainResidueDetails
BTHR388-GLY397

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P18079
ChainResidueDetails
BLYS391
ALYS391

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P18079
ChainResidueDetails
BARG163
BSER280
BLYS299
BTHR508
AARG163
ASER280
ALYS299
ATHR508

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: in other chain => ECO:0000269|PubMed:32499479
ChainResidueDetails
BCYS258
BPHE259
BHIS360
BTHR388
ACYS258
APHE259
AHIS360
ATHR388

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: in other chain => ECO:0000250|UniProtKB:P18079
ChainResidueDetails
BSER332
ASER332

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:32499479
ChainResidueDetails
BTHR420
BTHR421
ATHR420
ATHR421

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:32499479
ChainResidueDetails
BLYS391
ALYS391

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PDB entries from 2024-11-13

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