6HQV
Pentafunctional AROM Complex from Chaetomium thermophilum
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| A | 0003856 | molecular_function | 3-dehydroquinate synthase activity |
| A | 0003866 | molecular_function | 3-phosphoshikimate 1-carboxyvinyltransferase activity |
| A | 0004764 | molecular_function | shikimate 3-dehydrogenase (NADP+) activity |
| A | 0004765 | molecular_function | shikimate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0016829 | molecular_function | lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| B | 0003856 | molecular_function | 3-dehydroquinate synthase activity |
| B | 0003866 | molecular_function | 3-phosphoshikimate 1-carboxyvinyltransferase activity |
| B | 0004764 | molecular_function | shikimate 3-dehydrogenase (NADP+) activity |
| B | 0004765 | molecular_function | shikimate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0016829 | molecular_function | lyase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | binding site for residue NAD A 1601 |
| Chain | Residue |
| A | ASP56 |
| A | THR146 |
| A | THR147 |
| A | LEU149 |
| A | ASP153 |
| A | SER154 |
| A | LYS159 |
| A | LYS168 |
| A | ASN169 |
| A | PHE186 |
| A | THR189 |
| A | ASN58 |
| A | LEU190 |
| A | PRO191 |
| A | GLU194 |
| A | ASN197 |
| A | GLU201 |
| A | LYS257 |
| A | ZN1602 |
| A | GLU1603 |
| A | LEU59 |
| A | GLU90 |
| A | LYS93 |
| A | GLY121 |
| A | GLY122 |
| A | VAL123 |
| A | ASP126 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 1602 |
| Chain | Residue |
| A | GLU201 |
| A | HIS278 |
| A | HIS294 |
| A | NAD1601 |
| A | GLU1603 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue GLU A 1603 |
| Chain | Residue |
| A | ASP153 |
| A | LYS159 |
| A | GLU201 |
| A | LYS204 |
| A | LYS257 |
| A | ARG271 |
| A | LEU274 |
| A | ASN275 |
| A | HIS278 |
| A | HIS294 |
| A | NAD1601 |
| A | ZN1602 |
| A | PO41604 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 1604 |
| Chain | Residue |
| A | LYS159 |
| A | ASN169 |
| A | ASN275 |
| A | HIS282 |
| A | LYS363 |
| A | GLU1603 |
| B | ARG137 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue 3DS A 1605 |
| Chain | Residue |
| A | SER1062 |
| A | GLU1086 |
| A | ARG1088 |
| A | ARG1120 |
| A | LYS1207 |
| A | ARG1250 |
| A | PRO1258 |
| A | ALA1268 |
| A | ALA1269 |
| A | GLN1272 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue SKM A 1606 |
| Chain | Residue |
| A | SER1303 |
| A | SER1305 |
| A | SER1347 |
| A | THR1349 |
| A | LYS1353 |
| A | ASN1374 |
| A | ASP1394 |
| A | GLN1552 |
| A | GLN1556 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SKM A 1607 |
| Chain | Residue |
| A | ASP900 |
| A | ARG925 |
| A | GLY949 |
| A | GLY950 |
| A | ARG1005 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 1608 |
| Chain | Residue |
| A | GLY878 |
| A | ALA879 |
| A | GLY880 |
| A | LYS881 |
| A | SER882 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SKM A 1609 |
| Chain | Residue |
| A | SER423 |
| A | ARG427 |
| A | THR497 |
| A | SER576 |
| A | GLN577 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 1610 |
| Chain | Residue |
| A | ASP726 |
| A | GLU754 |
| A | ARG757 |
| A | HIS802 |
| A | ARG803 |
| site_id | AD2 |
| Number of Residues | 27 |
| Details | binding site for residue NAD B 1601 |
| Chain | Residue |
| B | ASP126 |
| B | THR146 |
| B | THR147 |
| B | LEU149 |
| B | ASP153 |
| B | SER154 |
| B | LYS159 |
| B | LYS168 |
| B | ASN169 |
| B | PHE186 |
| B | THR189 |
| B | LEU190 |
| B | PRO191 |
| B | GLU194 |
| B | ASN197 |
| B | GLU201 |
| B | LYS257 |
| B | ZN1602 |
| B | GLU1603 |
| B | ASP56 |
| B | ASN58 |
| B | LEU59 |
| B | GLU90 |
| B | LYS93 |
| B | GLY121 |
| B | GLY122 |
| B | VAL123 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 1602 |
| Chain | Residue |
| B | GLU201 |
| B | HIS278 |
| B | HIS294 |
| B | NAD1601 |
| B | GLU1603 |
| site_id | AD4 |
| Number of Residues | 13 |
| Details | binding site for residue GLU B 1603 |
| Chain | Residue |
| B | ASP153 |
| B | LYS159 |
| B | GLU201 |
| B | LYS204 |
| B | LYS257 |
| B | ARG271 |
| B | LEU274 |
| B | ASN275 |
| B | HIS278 |
| B | HIS294 |
| B | NAD1601 |
| B | ZN1602 |
| B | PO41604 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 B 1604 |
| Chain | Residue |
| A | ARG137 |
| B | LYS159 |
| B | ASN169 |
| B | ASN275 |
| B | HIS282 |
| B | LYS363 |
| B | GLU1603 |
| site_id | AD6 |
| Number of Residues | 10 |
| Details | binding site for residue SKM B 1606 |
| Chain | Residue |
| B | SER1303 |
| B | SER1305 |
| B | SER1347 |
| B | THR1349 |
| B | LYS1353 |
| B | ASN1374 |
| B | ASP1394 |
| B | TYR1524 |
| B | GLN1552 |
| B | GLN1556 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue SKM B 1607 |
| Chain | Residue |
| B | ASP900 |
| B | ARG925 |
| B | GLY948 |
| B | GLY949 |
| B | GLY950 |
| B | ARG1005 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue SKM B 1608 |
| Chain | Residue |
| B | SER423 |
| B | ARG427 |
| B | THR497 |
| B | SER576 |
| B | GLN577 |
| B | TYR607 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 B 1609 |
| Chain | Residue |
| B | ASP726 |
| B | GLU754 |
| B | ARG757 |
| B | HIS802 |
| B | ARG803 |
| site_id | AE1 |
| Number of Residues | 17 |
| Details | binding site for Di-peptide 3DS B 1605 and LYS B 1207 |
| Chain | Residue |
| B | SER1062 |
| B | GLU1086 |
| B | ARG1088 |
| B | THR1118 |
| B | ARG1120 |
| B | ILE1175 |
| B | ALA1176 |
| B | SER1177 |
| B | HIS1178 |
| B | HIS1179 |
| B | ILE1206 |
| B | LEU1208 |
| B | ILE1238 |
| B | ARG1250 |
| B | ALA1268 |
| B | ALA1269 |
| B | GLN1272 |
Functional Information from PROSITE/UniProt
| site_id | PS00104 |
| Number of Residues | 15 |
| Details | EPSP_SYNTHASE_1 EPSP synthase signature 1. LYlGNAGTASRfLtS |
| Chain | Residue | Details |
| A | LEU490-SER504 |
| site_id | PS00885 |
| Number of Residues | 19 |
| Details | EPSP_SYNTHASE_2 EPSP synthase signature 2. RvKECNRIaAMkdqLakFG |
| Chain | Residue | Details |
| A | ARG751-GLY769 |
| site_id | PS01028 |
| Number of Residues | 29 |
| Details | DEHYDROQUINASE_I Dehydroquinase class I active site. DLEMtmpdhilqavtdakgfts..IIaSHHD |
| Chain | Residue | Details |
| A | ASP1152-ASP1180 |
| site_id | PS01128 |
| Number of Residues | 28 |
| Details | SHIKIMATE_KINASE Shikimate kinase signature. RqaElelLqdviknqskgy.IFScGGGiV |
| Chain | Residue | Details |
| A | ARG925-VAL952 |
