6HN6

A revisited version of the apo structure of the ligand-binding domain of the human nuclear receptor RXR-ALPHA

Replaces:  1LBD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003707	molecular_function	nuclear steroid receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue CPS A 501

Chain	Residue
A	ALA252
A	GLY255
A	PRO258
A	SER260
A	PRO261
A	ASN262
A	ASN267
A	GLU453

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site_id	AC2
Number of Residues	6
Details	binding site for residue CPS A 502

Chain	Residue
A	LEU294
A	GLU453
A	GLU456
A	CPS503
A	CPS503
A	PRO293

---

site_id	AC3
Number of Residues	8
Details	binding site for residue CPS A 503

Chain	Residue
A	ALA252
A	ASN253
A	MET254
A	GLY255
A	PRO258
A	LEU330
A	CPS502
A	CPS502

---

site_id	AC4
Number of Residues	3
Details	binding site for residue CPS A 504

Chain	Residue
A	TYR249
A	ASN253
A	LEU256

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6

Chain	Residue	Details
A	ARG316
A	ALA327

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER259

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700

Chain	Residue	Details
A	SER260

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