6HN6

A revisited version of the apo structure of the ligand-binding domain of the human nuclear receptor RXR-ALPHA

Replaces:  1LBD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003707	molecular_function	nuclear steroid receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue CPS A 501

Chain	Residue
A	ALA252
A	GLY255
A	PRO258
A	SER260
A	PRO261
A	ASN262
A	ASN267
A	GLU453

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CPS A 502

Chain	Residue
A	LEU294
A	GLU453
A	GLU456
A	CPS503
A	CPS503
A	PRO293

---

site_id	AC3
Number of Residues	8
Details	binding site for residue CPS A 503

Chain	Residue
A	ALA252
A	ASN253
A	MET254
A	GLY255
A	PRO258
A	LEU330
A	CPS502
A	CPS502

---

site_id	AC4
Number of Residues	3
Details	binding site for residue CPS A 504

Chain	Residue
A	TYR249
A	ASN253
A	LEU256

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	231
Details	Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Region: {"description":"Required for nuclear export","evidences":[{"source":"PubMed","id":"15509776","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16107141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18800767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167885","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ACL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FC6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by MAPK8 and MAPK9","evidences":[{"source":"UniProtKB","id":"P28700","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---