6HML

POLYADPRIBOSYL GLYCOSIDASE IN COMPLEX WITH PDD00017299

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
A	0005975	biological_process	carbohydrate metabolic process
A	0006282	biological_process	regulation of DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue 73L A 1001

Chain	Residue
A	THR725
A	PHE902
A	HOH1196
A	HOH1275
A	ILE726
A	GLU727
A	GLN754
A	ARG758
A	TYR792
A	TYR795
A	ASN869
A	THR901

---

site_id	AC2
Number of Residues	5
Details	binding site for residue DMS A 1002

Chain	Residue
A	LYS559
A	TYR560
A	ASN561
A	VAL562
A	HOH1236

---

site_id	AC3
Number of Residues	2
Details	binding site for residue DMS A 1003

Chain	Residue
A	ILE484
A	VAL486

---

site_id	AC4
Number of Residues	2
Details	binding site for residue DMS A 1004

Chain	Residue
A	LEU473
A	LEU474

---

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL A 1005

Chain	Residue
A	GLU709
A	CYS711
A	GLU712
A	THR924
A	ASP927
A	LYS930

---

site_id	AC6
Number of Residues	8
Details	binding site for residue GOL A 1006

Chain	Residue
A	GLU727
A	GLN731
A	GLN788
A	HIS805
A	ASP807
A	GLY808
A	SER809
A	HOH1142

---

site_id	AC7
Number of Residues	5
Details	binding site for residue GOL A 1007

Chain	Residue
A	THR725
A	TYR792
A	HOH1108
A	HOH1136
A	HOH1263

---

site_id	AC8
Number of Residues	7
Details	binding site for residue SO4 A 1008

Chain	Residue
A	ARG535
A	TYR564
A	PRO643
A	ARG644
A	ASN646
A	HOH1137
A	HOH1256

---

site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 A 1009

Chain	Residue
A	LYS567
A	ARG842
A	HOH1169

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"23251397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22673905","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23251397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22673905","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23251397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22673905","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23251397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30472116","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9QYM2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Sterically intereferes with binding of internal ADP-D-ribose moieties of poly(ADP-ribose) to preferntially bind terminal moieties and drive exo-glycohydrolitic action","evidences":[{"source":"PubMed","id":"23917065","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---