6HK6
Human RIOK2 bound to inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004674 | molecular_function | protein serine/threonine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0004674 | molecular_function | protein serine/threonine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004672 | molecular_function | protein kinase activity |
| E | 0004674 | molecular_function | protein serine/threonine kinase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0006468 | biological_process | protein phosphorylation |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004672 | molecular_function | protein kinase activity |
| F | 0004674 | molecular_function | protein serine/threonine kinase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0006468 | biological_process | protein phosphorylation |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004672 | molecular_function | protein kinase activity |
| G | 0004674 | molecular_function | protein serine/threonine kinase activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0006468 | biological_process | protein phosphorylation |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004672 | molecular_function | protein kinase activity |
| H | 0004674 | molecular_function | protein serine/threonine kinase activity |
| H | 0005524 | molecular_function | ATP binding |
| H | 0006468 | biological_process | protein phosphorylation |
| I | 0003824 | molecular_function | catalytic activity |
| I | 0004672 | molecular_function | protein kinase activity |
| I | 0004674 | molecular_function | protein serine/threonine kinase activity |
| I | 0005524 | molecular_function | ATP binding |
| I | 0006468 | biological_process | protein phosphorylation |
| J | 0003824 | molecular_function | catalytic activity |
| J | 0004672 | molecular_function | protein kinase activity |
| J | 0004674 | molecular_function | protein serine/threonine kinase activity |
| J | 0005524 | molecular_function | ATP binding |
| J | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue G8H A 401 |
| Chain | Residue |
| A | MET101 |
| A | ILE111 |
| A | ALA121 |
| A | GLU189 |
| A | ILE191 |
| A | GLY193 |
| A | ILE235 |
| A | ILE245 |
| F | HIS200 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 402 |
| Chain | Residue |
| A | ARG14 |
| A | ARG18 |
| H | HIS200 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | ASP81 |
| A | VAL97 |
| A | TYR110 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | ASN77 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | SER107 |
| A | ASP108 |
| A | ARG129 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue G8H B 401 |
| Chain | Residue |
| B | MET101 |
| B | ALA121 |
| B | GLU189 |
| B | LEU190 |
| B | ILE191 |
| B | GLY193 |
| B | ILE235 |
| B | ILE245 |
| I | HIS200 |
| I | ARG276 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue EPE B 402 |
| Chain | Residue |
| B | ARG171 |
| B | HIS222 |
| B | GLU293 |
| B | ASP294 |
| B | THR295 |
| C | ASP294 |
| C | THR295 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 403 |
| Chain | Residue |
| B | ASP81 |
| B | VAL97 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 404 |
| Chain | Residue |
| A | ASP271 |
| B | TRP260 |
| B | ASP263 |
| B | LYS267 |
| B | HOH521 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 405 |
| Chain | Residue |
| A | TRP260 |
| A | ASP263 |
| A | LYS267 |
| B | CYS268 |
| B | ASP271 |
| B | LYS275 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residue G8H C 401 |
| Chain | Residue |
| C | MET101 |
| C | ILE111 |
| C | ALA121 |
| C | GLU189 |
| C | ILE191 |
| C | GLY193 |
| C | ILE235 |
| C | ILE245 |
| D | HIS200 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue G8H D 401 |
| Chain | Residue |
| C | HIS200 |
| D | MET101 |
| D | ILE111 |
| D | ALA121 |
| D | GLU189 |
| D | ILE191 |
| D | GLY193 |
| D | ILE235 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue EPE D 402 |
| Chain | Residue |
| D | HIS222 |
| D | GLU293 |
| D | ASP294 |
| D | THR295 |
| G | GLU293 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue G8H E 401 |
| Chain | Residue |
| E | MET101 |
| E | ILE111 |
| E | ALA121 |
| E | GLU189 |
| E | ILE191 |
| E | GLY193 |
| E | ILE235 |
| J | HIS200 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue EPE E 402 |
| Chain | Residue |
| E | ARG171 |
| E | HIS222 |
| E | GLU293 |
| E | ASP294 |
| E | THR295 |
| F | THR295 |
| site_id | AD7 |
| Number of Residues | 9 |
| Details | binding site for residue G8H F 401 |
| Chain | Residue |
| A | HIS200 |
| F | MET101 |
| F | ILE109 |
| F | ILE111 |
| F | ALA121 |
| F | GLU189 |
| F | ILE191 |
| F | GLY193 |
| F | ILE235 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO F 402 |
| Chain | Residue |
| F | ASP81 |
| F | VAL97 |
| F | TYR110 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue G8H G 600 |
| Chain | Residue |
| G | ILE191 |
| G | GLY193 |
| G | ILE235 |
| G | ALA121 |
| G | GLU189 |
| site_id | AE1 |
| Number of Residues | 9 |
| Details | binding site for residue G8H H 401 |
| Chain | Residue |
| A | LYS45 |
| H | MET101 |
| H | ILE111 |
| H | ALA121 |
| H | GLU189 |
| H | ILE191 |
| H | GLY193 |
| H | ILE235 |
| H | ILE245 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue EPE H 402 |
| Chain | Residue |
| H | GLU293 |
| H | THR295 |
| site_id | AE3 |
| Number of Residues | 1 |
| Details | binding site for residue CL H 403 |
| Chain | Residue |
| H | TYR164 |
| site_id | AE4 |
| Number of Residues | 8 |
| Details | binding site for residue G8H I 600 |
| Chain | Residue |
| B | HIS200 |
| I | MET101 |
| I | ILE111 |
| I | ALA121 |
| I | GLU189 |
| I | ILE191 |
| I | GLY193 |
| I | ILE235 |
| site_id | AE5 |
| Number of Residues | 8 |
| Details | binding site for residue G8H J 600 |
| Chain | Residue |
| E | HIS200 |
| J | MET101 |
| J | ILE111 |
| J | ALA121 |
| J | GLU189 |
| J | ILE191 |
| J | GLY193 |
| J | ILE235 |
Functional Information from PROSITE/UniProt
| site_id | PS01245 |
| Number of Residues | 12 |
| Details | RIO1 RIO1/ZK632.3/MJ0444 family signature. LIHGDFNEFNlI |
| Chain | Residue | Details |
| A | LEU224-ILE235 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
