Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HK0

X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) F16'S pore mutant (F247S) with alternate M4 conformation.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0006811	biological_process	monoatomic ion transport
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0006811	biological_process	monoatomic ion transport
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0006811	biological_process	monoatomic ion transport
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0006811	biological_process	monoatomic ion transport
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0006811	biological_process	monoatomic ion transport
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue LMT A 401

Chain	Residue
A	THR259
A	GLN264
E	TRP206

site_id	AC2
Number of Residues	3
Details	binding site for residue LMT B 401

Chain	Residue
A	TRP206
B	THR259
B	GLN264

site_id	AC3
Number of Residues	3
Details	binding site for residue LMT C 401

Chain	Residue
B	TRP206
C	THR259
C	GLN264

site_id	AC4
Number of Residues	4
Details	binding site for residue LMT D 401

Chain	Residue
C	SER202
C	TRP206
D	THR259
D	GLN264

site_id	AC5
Number of Residues	3
Details	binding site for residue LMT G 401

Chain	Residue
F	TRP206
G	THR259
G	GLN264

site_id	AC6
Number of Residues	4
Details	binding site for residue LMT I 401

Chain	Residue
H	SER202
H	TRP206
I	THR259
I	GLN264

site_id	AC7
Number of Residues	3
Details	binding site for residue LMT I 402

Chain	Residue
I	TRP206
J	THR259
J	GLN264

site_id	AC8
Number of Residues	11
Details	binding site for Poly-Saccharide residues GLN E 264 through LMT E 401

Chain	Residue
D	SER202
D	TRP206
E	THR259
E	THR260
E	VAL261
E	ILE262
E	ASP263
E	MET265
E	ILE266
E	ILE267
E	ALA268

site_id	AC9
Number of Residues	10
Details	binding site for Poly-Saccharide residues GLN F 264 through LMT F 401

Chain	Residue
F	THR259
F	THR260
F	VAL261
F	ILE262
F	ASP263
F	MET265
F	ILE266
F	ILE267
F	ALA268
J	TRP206

site_id	AD1
Number of Residues	11
Details	binding site for Poly-Saccharide residues TRP G 206 through LMT G 402

Chain	Residue
G	SER202
G	TYR203
G	TYR204
G	LEU205
G	SER207
G	PHE208
G	LEU210
G	PRO211
H	THR259
H	GLN264
H	ILE267

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	600
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	LEU205-LEU225
D	LEU205-LEU225
D	THR234-PRO254
D	MET265-HIS285
E	LEU205-LEU225
E	THR234-PRO254
E	MET265-HIS285
F	LEU205-LEU225
F	THR234-PRO254
F	MET265-HIS285
G	LEU205-LEU225
A	THR234-PRO254
G	THR234-PRO254
G	MET265-HIS285
H	LEU205-LEU225
H	THR234-PRO254
H	MET265-HIS285
I	LEU205-LEU225
I	THR234-PRO254
I	MET265-HIS285
J	LEU205-LEU225
J	THR234-PRO254
A	MET265-HIS285
J	MET265-HIS285
B	LEU205-LEU225
B	THR234-PRO254
B	MET265-HIS285
C	LEU205-LEU225
C	THR234-PRO254
C	MET265-HIS285

site_id	SWS_FT_FI2
Number of Residues	220
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	GLU226-GLN233
E	ARG286-ARG301
F	GLU226-GLN233
F	ARG286-ARG301
G	GLU226-GLN233
G	ARG286-ARG301
H	GLU226-GLN233
H	ARG286-ARG301
I	GLU226-GLN233
I	ARG286-ARG301
J	GLU226-GLN233
A	ARG286-ARG301
J	ARG286-ARG301
B	GLU226-GLN233
B	ARG286-ARG301
C	GLU226-GLN233
C	ARG286-ARG301
D	GLU226-GLN233
D	ARG286-ARG301
E	GLU226-GLN233

site_id	SWS_FT_FI3
Number of Residues	90
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
A	ARG255-GLN264
J	ARG255-GLN264
B	ARG255-GLN264
C	ARG255-GLN264
D	ARG255-GLN264
E	ARG255-GLN264
F	ARG255-GLN264
G	ARG255-GLN264
H	ARG255-GLN264
I	ARG255-GLN264

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)