6HJZ
Xray structure of GLIC in complex with succinate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004888 | molecular_function | transmembrane signaling receptor activity |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0016020 | cellular_component | membrane |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
B | 0004888 | molecular_function | transmembrane signaling receptor activity |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0016020 | cellular_component | membrane |
B | 0034220 | biological_process | monoatomic ion transmembrane transport |
C | 0004888 | molecular_function | transmembrane signaling receptor activity |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0016020 | cellular_component | membrane |
C | 0034220 | biological_process | monoatomic ion transmembrane transport |
D | 0004888 | molecular_function | transmembrane signaling receptor activity |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0016020 | cellular_component | membrane |
D | 0034220 | biological_process | monoatomic ion transmembrane transport |
E | 0004888 | molecular_function | transmembrane signaling receptor activity |
E | 0005216 | molecular_function | monoatomic ion channel activity |
E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
E | 0006811 | biological_process | monoatomic ion transport |
E | 0016020 | cellular_component | membrane |
E | 0034220 | biological_process | monoatomic ion transmembrane transport |
F | 0004888 | molecular_function | transmembrane signaling receptor activity |
F | 0005216 | molecular_function | monoatomic ion channel activity |
F | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
F | 0006811 | biological_process | monoatomic ion transport |
F | 0016020 | cellular_component | membrane |
F | 0034220 | biological_process | monoatomic ion transmembrane transport |
G | 0004888 | molecular_function | transmembrane signaling receptor activity |
G | 0005216 | molecular_function | monoatomic ion channel activity |
G | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
G | 0006811 | biological_process | monoatomic ion transport |
G | 0016020 | cellular_component | membrane |
G | 0034220 | biological_process | monoatomic ion transmembrane transport |
H | 0004888 | molecular_function | transmembrane signaling receptor activity |
H | 0005216 | molecular_function | monoatomic ion channel activity |
H | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
H | 0006811 | biological_process | monoatomic ion transport |
H | 0016020 | cellular_component | membrane |
H | 0034220 | biological_process | monoatomic ion transmembrane transport |
I | 0004888 | molecular_function | transmembrane signaling receptor activity |
I | 0005216 | molecular_function | monoatomic ion channel activity |
I | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
I | 0006811 | biological_process | monoatomic ion transport |
I | 0016020 | cellular_component | membrane |
I | 0034220 | biological_process | monoatomic ion transmembrane transport |
J | 0004888 | molecular_function | transmembrane signaling receptor activity |
J | 0005216 | molecular_function | monoatomic ion channel activity |
J | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
J | 0006811 | biological_process | monoatomic ion transport |
J | 0016020 | cellular_component | membrane |
J | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | binding site for residue PLC A 401 |
Chain | Residue |
A | ARG118 |
A | PHE121 |
A | TYR194 |
A | TYR254 |
A | ASN307 |
A | PLC403 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue PLC A 402 |
Chain | Residue |
A | THR214 |
A | TRP217 |
site_id | AC3 |
Number of Residues | 1 |
Details | binding site for residue PLC A 403 |
Chain | Residue |
A | PLC401 |
site_id | AC4 |
Number of Residues | 2 |
Details | binding site for residue CL A 404 |
Chain | Residue |
A | PHE78 |
A | ARG85 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue CL A 405 |
Chain | Residue |
A | ASN139 |
A | LEU180 |
D | ALA175 |
site_id | AC6 |
Number of Residues | 3 |
Details | binding site for residue CL A 406 |
Chain | Residue |
A | ALA175 |
D | ASN139 |
D | LEU180 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue NA A 407 |
Chain | Residue |
A | ILE71 |
A | TRP72 |
A | ILE73 |
site_id | AC8 |
Number of Residues | 1 |
Details | binding site for residue LMT A 408 |
Chain | Residue |
C | LMT407 |
site_id | AC9 |
Number of Residues | 9 |
Details | binding site for residue SIN A 410 |
Chain | Residue |
A | ARG77 |
A | ILE131 |
A | PHE174 |
A | LEU176 |
A | GLU181 |
E | ILE25 |
E | PHE42 |
E | ARG105 |
E | ASN152 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue SIN A 411 |
Chain | Residue |
A | ILE73 |
A | PRO74 |
A | GLU75 |
A | ILE76 |
A | ARG77 |
A | ARG85 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue PLC B 402 |
Chain | Residue |
B | ARG118 |
B | PHE121 |
B | TYR194 |
B | TYR254 |
B | ASN307 |
B | PHE315 |
B | PLC404 |
site_id | AD3 |
Number of Residues | 2 |
Details | binding site for residue PLC B 403 |
Chain | Residue |
B | THR214 |
B | TRP217 |
site_id | AD4 |
Number of Residues | 1 |
Details | binding site for residue PLC B 404 |
Chain | Residue |
B | PLC402 |
site_id | AD5 |
Number of Residues | 2 |
Details | binding site for residue CL B 405 |
Chain | Residue |
B | PHE78 |
B | ARG85 |
site_id | AD6 |
Number of Residues | 3 |
Details | binding site for residue NA B 406 |
Chain | Residue |
B | PRO68 |
B | ILE71 |
B | ILE73 |
site_id | AD7 |
Number of Residues | 1 |
Details | binding site for residue LMT B 407 |
Chain | Residue |
B | ALA237 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue SIN B 408 |
Chain | Residue |
B | PRO74 |
B | ILE76 |
B | ARG85 |
B | ALA87 |
site_id | AD9 |
Number of Residues | 9 |
Details | binding site for residue SIN B 409 |
Chain | Residue |
B | ILE25 |
B | PHE42 |
B | ARG105 |
B | ASN152 |
C | ARG77 |
C | ILE131 |
C | PHE174 |
C | LEU176 |
C | GLU181 |
site_id | AE1 |
Number of Residues | 9 |
Details | binding site for residue SIN B 410 |
Chain | Residue |
A | TYR23 |
A | ILE25 |
A | PHE42 |
A | ARG105 |
A | ASN152 |
B | ARG77 |
B | ILE131 |
B | LEU176 |
B | GLU181 |
site_id | AE2 |
Number of Residues | 9 |
Details | binding site for residue SIN C 401 |
Chain | Residue |
C | ILE25 |
C | PHE42 |
C | ARG105 |
C | ASN152 |
D | ARG77 |
D | VAL79 |
D | ILE131 |
D | LEU176 |
D | GLU181 |
site_id | AE3 |
Number of Residues | 5 |
Details | binding site for residue PLC C 402 |
Chain | Residue |
C | ARG118 |
C | PHE121 |
C | TYR254 |
C | PHE315 |
C | PLC404 |
site_id | AE4 |
Number of Residues | 2 |
Details | binding site for residue PLC C 403 |
Chain | Residue |
C | THR214 |
C | TRP217 |
site_id | AE5 |
Number of Residues | 1 |
Details | binding site for residue PLC C 404 |
Chain | Residue |
C | PLC402 |
site_id | AE6 |
Number of Residues | 2 |
Details | binding site for residue CL C 405 |
Chain | Residue |
C | PHE78 |
C | ARG85 |
site_id | AE7 |
Number of Residues | 3 |
Details | binding site for residue NA C 406 |
Chain | Residue |
C | PRO68 |
C | ILE71 |
C | ILE73 |
site_id | AE8 |
Number of Residues | 1 |
Details | binding site for residue LMT C 407 |
Chain | Residue |
A | LMT408 |
site_id | AE9 |
Number of Residues | 4 |
Details | binding site for residue SIN C 408 |
Chain | Residue |
C | ARG77 |
C | ARG85 |
C | PRO74 |
C | ILE76 |
site_id | AF1 |
Number of Residues | 7 |
Details | binding site for residue PLC D 401 |
Chain | Residue |
D | ARG118 |
D | PHE121 |
D | TYR194 |
D | TYR254 |
D | ASN307 |
D | PHE315 |
D | PLC403 |
site_id | AF2 |
Number of Residues | 2 |
Details | binding site for residue PLC D 402 |
Chain | Residue |
D | THR214 |
D | TRP217 |
site_id | AF3 |
Number of Residues | 1 |
Details | binding site for residue PLC D 403 |
Chain | Residue |
D | PLC401 |
site_id | AF4 |
Number of Residues | 2 |
Details | binding site for residue CL D 404 |
Chain | Residue |
D | PHE78 |
D | ARG85 |
site_id | AF5 |
Number of Residues | 3 |
Details | binding site for residue NA D 405 |
Chain | Residue |
D | ILE71 |
D | ILE73 |
D | SIN407 |
site_id | AF6 |
Number of Residues | 8 |
Details | binding site for residue SIN D 407 |
Chain | Residue |
D | ILE73 |
D | PRO74 |
D | GLU75 |
D | ILE76 |
D | ARG85 |
D | TYR102 |
D | GLU104 |
D | NA405 |
site_id | AF7 |
Number of Residues | 6 |
Details | binding site for residue PLC E 401 |
Chain | Residue |
E | ARG118 |
E | PHE121 |
E | TYR194 |
E | TYR254 |
E | ASN307 |
E | PLC403 |
site_id | AF8 |
Number of Residues | 2 |
Details | binding site for residue PLC E 402 |
Chain | Residue |
E | THR214 |
E | TRP217 |
site_id | AF9 |
Number of Residues | 1 |
Details | binding site for residue PLC E 403 |
Chain | Residue |
E | PLC401 |
site_id | AG1 |
Number of Residues | 2 |
Details | binding site for residue CL E 404 |
Chain | Residue |
E | PHE78 |
E | ARG85 |
site_id | AG2 |
Number of Residues | 3 |
Details | binding site for residue NA E 405 |
Chain | Residue |
E | PRO68 |
E | ILE71 |
E | ILE73 |
site_id | AG3 |
Number of Residues | 2 |
Details | binding site for residue LMT E 406 |
Chain | Residue |
D | ALA237 |
E | THR244 |
site_id | AG4 |
Number of Residues | 5 |
Details | binding site for residue SIN E 407 |
Chain | Residue |
E | PRO74 |
E | ARG85 |
E | ALA87 |
E | TYR102 |
E | GLU104 |
site_id | AG5 |
Number of Residues | 7 |
Details | binding site for residue SIN E 408 |
Chain | Residue |
D | ILE25 |
D | PHE42 |
D | ARG105 |
D | ASN152 |
E | ARG77 |
E | ILE131 |
E | GLU181 |
site_id | AG6 |
Number of Residues | 7 |
Details | binding site for residue PLC F 401 |
Chain | Residue |
F | ARG118 |
F | PHE121 |
F | TYR194 |
F | TYR254 |
F | ASN307 |
F | PHE315 |
F | PLC403 |
site_id | AG7 |
Number of Residues | 2 |
Details | binding site for residue PLC F 402 |
Chain | Residue |
F | THR214 |
F | TRP217 |
site_id | AG8 |
Number of Residues | 1 |
Details | binding site for residue PLC F 403 |
Chain | Residue |
F | PLC401 |
site_id | AG9 |
Number of Residues | 2 |
Details | binding site for residue CL F 404 |
Chain | Residue |
F | PHE78 |
F | ARG85 |
site_id | AH1 |
Number of Residues | 2 |
Details | binding site for residue NA F 405 |
Chain | Residue |
F | PRO68 |
F | ILE71 |
site_id | AH2 |
Number of Residues | 2 |
Details | binding site for residue LMT F 407 |
Chain | Residue |
G | LMT407 |
J | LMT406 |
site_id | AH3 |
Number of Residues | 10 |
Details | binding site for residue SIN F 408 |
Chain | Residue |
F | ARG77 |
F | VAL79 |
F | ILE131 |
F | LEU176 |
F | GLU181 |
J | TYR23 |
J | ILE25 |
J | PHE42 |
J | ARG105 |
J | ASN152 |
site_id | AH4 |
Number of Residues | 5 |
Details | binding site for residue SIN F 409 |
Chain | Residue |
F | ILE73 |
F | PRO74 |
F | GLU75 |
F | ILE76 |
F | ARG85 |
site_id | AH5 |
Number of Residues | 9 |
Details | binding site for residue SIN G 401 |
Chain | Residue |
G | ILE25 |
G | PHE42 |
G | ARG105 |
G | ASN152 |
H | ARG77 |
H | ILE131 |
H | PHE174 |
H | LEU176 |
H | GLU181 |
site_id | AH6 |
Number of Residues | 7 |
Details | binding site for residue PLC G 402 |
Chain | Residue |
G | ARG118 |
G | PHE121 |
G | TYR194 |
G | TYR254 |
G | ASN307 |
G | PHE315 |
G | PLC404 |
site_id | AH7 |
Number of Residues | 2 |
Details | binding site for residue PLC G 403 |
Chain | Residue |
G | THR214 |
G | TRP217 |
site_id | AH8 |
Number of Residues | 1 |
Details | binding site for residue PLC G 404 |
Chain | Residue |
G | PLC402 |
site_id | AH9 |
Number of Residues | 2 |
Details | binding site for residue CL G 405 |
Chain | Residue |
G | PHE78 |
G | ARG85 |
site_id | AI1 |
Number of Residues | 2 |
Details | binding site for residue NA G 406 |
Chain | Residue |
G | PRO68 |
G | ILE71 |
site_id | AI2 |
Number of Residues | 2 |
Details | binding site for residue LMT G 407 |
Chain | Residue |
F | LMT407 |
G | THR244 |
site_id | AI3 |
Number of Residues | 8 |
Details | binding site for residue SIN G 408 |
Chain | Residue |
F | ILE25 |
F | PHE42 |
F | ARG105 |
F | ASN152 |
G | ARG77 |
G | ILE131 |
G | LEU176 |
G | GLU181 |
site_id | AI4 |
Number of Residues | 5 |
Details | binding site for residue SIN G 410 |
Chain | Residue |
G | PRO74 |
G | GLU75 |
G | ILE76 |
G | ARG77 |
G | ARG85 |
site_id | AI5 |
Number of Residues | 6 |
Details | binding site for residue PLC H 401 |
Chain | Residue |
H | PHE121 |
H | TYR194 |
H | TYR254 |
H | ASN307 |
H | PHE315 |
H | PLC403 |
site_id | AI6 |
Number of Residues | 2 |
Details | binding site for residue PLC H 402 |
Chain | Residue |
H | THR214 |
H | TRP217 |
site_id | AI7 |
Number of Residues | 1 |
Details | binding site for residue PLC H 403 |
Chain | Residue |
H | PLC401 |
site_id | AI8 |
Number of Residues | 2 |
Details | binding site for residue CL H 404 |
Chain | Residue |
H | PHE78 |
H | ARG85 |
site_id | AI9 |
Number of Residues | 3 |
Details | binding site for residue CL H 405 |
Chain | Residue |
H | SER134 |
H | ASN139 |
H | LEU180 |
site_id | AJ1 |
Number of Residues | 1 |
Details | binding site for residue CL H 406 |
Chain | Residue |
H | ALA175 |
site_id | AJ2 |
Number of Residues | 3 |
Details | binding site for residue NA H 407 |
Chain | Residue |
H | PRO68 |
H | ILE71 |
H | ILE73 |
site_id | AJ3 |
Number of Residues | 4 |
Details | binding site for residue SIN H 409 |
Chain | Residue |
H | ILE73 |
H | PRO74 |
H | ILE76 |
H | ARG85 |
site_id | AJ4 |
Number of Residues | 6 |
Details | binding site for residue PLC I 401 |
Chain | Residue |
I | ARG118 |
I | PHE121 |
I | TYR194 |
I | TYR254 |
I | ASN307 |
I | PHE315 |
site_id | AJ5 |
Number of Residues | 2 |
Details | binding site for residue PLC I 402 |
Chain | Residue |
I | THR214 |
I | TRP217 |
site_id | AJ6 |
Number of Residues | 2 |
Details | binding site for residue CL I 404 |
Chain | Residue |
I | PHE78 |
I | ARG85 |
site_id | AJ7 |
Number of Residues | 2 |
Details | binding site for residue NA I 405 |
Chain | Residue |
I | ILE71 |
I | ILE73 |
site_id | AJ8 |
Number of Residues | 1 |
Details | binding site for residue LMT I 406 |
Chain | Residue |
I | ALA237 |
site_id | AJ9 |
Number of Residues | 8 |
Details | binding site for residue SIN I 407 |
Chain | Residue |
I | ILE25 |
I | PHE42 |
I | ARG105 |
I | ASN152 |
J | ARG77 |
J | ILE131 |
J | LEU176 |
J | GLU181 |
site_id | AK1 |
Number of Residues | 8 |
Details | binding site for residue SIN I 408 |
Chain | Residue |
H | ILE25 |
H | PHE42 |
H | ARG105 |
H | ASN152 |
I | ARG77 |
I | ILE131 |
I | LEU176 |
I | GLU181 |
site_id | AK2 |
Number of Residues | 5 |
Details | binding site for residue SIN I 409 |
Chain | Residue |
I | ILE73 |
I | PRO74 |
I | GLU75 |
I | ILE76 |
I | ARG85 |
site_id | AK3 |
Number of Residues | 6 |
Details | binding site for residue PLC J 401 |
Chain | Residue |
J | ARG118 |
J | PHE121 |
J | TYR194 |
J | TYR254 |
J | ASN307 |
J | PLC403 |
site_id | AK4 |
Number of Residues | 2 |
Details | binding site for residue PLC J 402 |
Chain | Residue |
J | THR214 |
J | TRP217 |
site_id | AK5 |
Number of Residues | 1 |
Details | binding site for residue PLC J 403 |
Chain | Residue |
J | PLC401 |
site_id | AK6 |
Number of Residues | 2 |
Details | binding site for residue CL J 404 |
Chain | Residue |
J | PHE78 |
J | ARG85 |
site_id | AK7 |
Number of Residues | 3 |
Details | binding site for residue NA J 405 |
Chain | Residue |
J | PRO68 |
J | ILE71 |
J | ILE73 |
site_id | AK8 |
Number of Residues | 2 |
Details | binding site for residue LMT J 406 |
Chain | Residue |
F | LMT407 |
J | ALA237 |
site_id | AK9 |
Number of Residues | 6 |
Details | binding site for residue SIN J 407 |
Chain | Residue |
J | PRO68 |
J | PRO74 |
J | ILE76 |
J | ARG85 |
J | VAL89 |
J | TYR102 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1980 |
Details | TOPO_DOM: Periplasmic => ECO:0000255 |
Chain | Residue | Details |
A | GLN2-GLN193 | |
E | ASN245-MET252 | |
F | GLN2-GLN193 | |
F | ASN245-MET252 | |
G | GLN2-GLN193 | |
G | ASN245-MET252 | |
H | GLN2-GLN193 | |
H | ASN245-MET252 | |
I | GLN2-GLN193 | |
I | ASN245-MET252 | |
J | GLN2-GLN193 | |
A | ASN245-MET252 | |
J | ASN245-MET252 | |
B | GLN2-GLN193 | |
B | ASN245-MET252 | |
C | GLN2-GLN193 | |
C | ASN245-MET252 | |
D | GLN2-GLN193 | |
D | ASN245-MET252 | |
E | GLN2-GLN193 |
site_id | SWS_FT_FI2 |
Number of Residues | 1060 |
Details | TRANSMEM: Helical |
Chain | Residue | Details |
A | TYR194-PHE216 | |
C | SER220-THR244 | |
C | THR253-VAL281 | |
C | PRO285-PHE317 | |
D | TYR194-PHE216 | |
D | SER220-THR244 | |
D | THR253-VAL281 | |
D | PRO285-PHE317 | |
E | TYR194-PHE216 | |
E | SER220-THR244 | |
E | THR253-VAL281 | |
A | SER220-THR244 | |
E | PRO285-PHE317 | |
F | TYR194-PHE216 | |
F | SER220-THR244 | |
F | THR253-VAL281 | |
F | PRO285-PHE317 | |
G | TYR194-PHE216 | |
G | SER220-THR244 | |
G | THR253-VAL281 | |
G | PRO285-PHE317 | |
H | TYR194-PHE216 | |
A | THR253-VAL281 | |
H | SER220-THR244 | |
H | THR253-VAL281 | |
H | PRO285-PHE317 | |
I | TYR194-PHE216 | |
I | SER220-THR244 | |
I | THR253-VAL281 | |
I | PRO285-PHE317 | |
J | TYR194-PHE216 | |
J | SER220-THR244 | |
J | THR253-VAL281 | |
A | PRO285-PHE317 | |
J | PRO285-PHE317 | |
B | TYR194-PHE216 | |
B | SER220-THR244 | |
B | THR253-VAL281 | |
B | PRO285-PHE317 | |
C | TYR194-PHE216 |
site_id | SWS_FT_FI3 |
Number of Residues | 40 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | TRP217-THR219 | |
E | GLU282-GLN284 | |
F | TRP217-THR219 | |
F | GLU282-GLN284 | |
G | TRP217-THR219 | |
G | GLU282-GLN284 | |
H | TRP217-THR219 | |
H | GLU282-GLN284 | |
I | TRP217-THR219 | |
I | GLU282-GLN284 | |
J | TRP217-THR219 | |
A | GLU282-GLN284 | |
J | GLU282-GLN284 | |
B | TRP217-THR219 | |
B | GLU282-GLN284 | |
C | TRP217-THR219 | |
C | GLU282-GLN284 | |
D | TRP217-THR219 | |
D | GLU282-GLN284 | |
E | TRP217-THR219 |