6HJZ
Xray structure of GLIC in complex with succinate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
| F | 0004888 | molecular_function | transmembrane signaling receptor activity |
| F | 0005216 | molecular_function | monoatomic ion channel activity |
| F | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| F | 0006811 | biological_process | monoatomic ion transport |
| F | 0016020 | cellular_component | membrane |
| F | 0034220 | biological_process | monoatomic ion transmembrane transport |
| G | 0004888 | molecular_function | transmembrane signaling receptor activity |
| G | 0005216 | molecular_function | monoatomic ion channel activity |
| G | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| G | 0006811 | biological_process | monoatomic ion transport |
| G | 0016020 | cellular_component | membrane |
| G | 0034220 | biological_process | monoatomic ion transmembrane transport |
| H | 0004888 | molecular_function | transmembrane signaling receptor activity |
| H | 0005216 | molecular_function | monoatomic ion channel activity |
| H | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| H | 0006811 | biological_process | monoatomic ion transport |
| H | 0016020 | cellular_component | membrane |
| H | 0034220 | biological_process | monoatomic ion transmembrane transport |
| I | 0004888 | molecular_function | transmembrane signaling receptor activity |
| I | 0005216 | molecular_function | monoatomic ion channel activity |
| I | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| I | 0006811 | biological_process | monoatomic ion transport |
| I | 0016020 | cellular_component | membrane |
| I | 0034220 | biological_process | monoatomic ion transmembrane transport |
| J | 0004888 | molecular_function | transmembrane signaling receptor activity |
| J | 0005216 | molecular_function | monoatomic ion channel activity |
| J | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| J | 0006811 | biological_process | monoatomic ion transport |
| J | 0016020 | cellular_component | membrane |
| J | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue PLC A 401 |
| Chain | Residue |
| A | ARG118 |
| A | PHE121 |
| A | TYR194 |
| A | TYR254 |
| A | ASN307 |
| A | PLC403 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue PLC A 402 |
| Chain | Residue |
| A | THR214 |
| A | TRP217 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue PLC A 403 |
| Chain | Residue |
| A | PLC401 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 404 |
| Chain | Residue |
| A | PHE78 |
| A | ARG85 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 405 |
| Chain | Residue |
| A | ASN139 |
| A | LEU180 |
| D | ALA175 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 406 |
| Chain | Residue |
| A | ALA175 |
| D | ASN139 |
| D | LEU180 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 407 |
| Chain | Residue |
| A | ILE71 |
| A | TRP72 |
| A | ILE73 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue LMT A 408 |
| Chain | Residue |
| C | LMT407 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue SIN A 410 |
| Chain | Residue |
| A | ARG77 |
| A | ILE131 |
| A | PHE174 |
| A | LEU176 |
| A | GLU181 |
| E | ILE25 |
| E | PHE42 |
| E | ARG105 |
| E | ASN152 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue SIN A 411 |
| Chain | Residue |
| A | ILE73 |
| A | PRO74 |
| A | GLU75 |
| A | ILE76 |
| A | ARG77 |
| A | ARG85 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue PLC B 402 |
| Chain | Residue |
| B | ARG118 |
| B | PHE121 |
| B | TYR194 |
| B | TYR254 |
| B | ASN307 |
| B | PHE315 |
| B | PLC404 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue PLC B 403 |
| Chain | Residue |
| B | THR214 |
| B | TRP217 |
| site_id | AD4 |
| Number of Residues | 1 |
| Details | binding site for residue PLC B 404 |
| Chain | Residue |
| B | PLC402 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 405 |
| Chain | Residue |
| B | PHE78 |
| B | ARG85 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue NA B 406 |
| Chain | Residue |
| B | PRO68 |
| B | ILE71 |
| B | ILE73 |
| site_id | AD7 |
| Number of Residues | 1 |
| Details | binding site for residue LMT B 407 |
| Chain | Residue |
| B | ALA237 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue SIN B 408 |
| Chain | Residue |
| B | PRO74 |
| B | ILE76 |
| B | ARG85 |
| B | ALA87 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue SIN B 409 |
| Chain | Residue |
| B | ILE25 |
| B | PHE42 |
| B | ARG105 |
| B | ASN152 |
| C | ARG77 |
| C | ILE131 |
| C | PHE174 |
| C | LEU176 |
| C | GLU181 |
| site_id | AE1 |
| Number of Residues | 9 |
| Details | binding site for residue SIN B 410 |
| Chain | Residue |
| A | TYR23 |
| A | ILE25 |
| A | PHE42 |
| A | ARG105 |
| A | ASN152 |
| B | ARG77 |
| B | ILE131 |
| B | LEU176 |
| B | GLU181 |
| site_id | AE2 |
| Number of Residues | 9 |
| Details | binding site for residue SIN C 401 |
| Chain | Residue |
| C | ILE25 |
| C | PHE42 |
| C | ARG105 |
| C | ASN152 |
| D | ARG77 |
| D | VAL79 |
| D | ILE131 |
| D | LEU176 |
| D | GLU181 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue PLC C 402 |
| Chain | Residue |
| C | ARG118 |
| C | PHE121 |
| C | TYR254 |
| C | PHE315 |
| C | PLC404 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue PLC C 403 |
| Chain | Residue |
| C | THR214 |
| C | TRP217 |
| site_id | AE5 |
| Number of Residues | 1 |
| Details | binding site for residue PLC C 404 |
| Chain | Residue |
| C | PLC402 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 405 |
| Chain | Residue |
| C | PHE78 |
| C | ARG85 |
| site_id | AE7 |
| Number of Residues | 3 |
| Details | binding site for residue NA C 406 |
| Chain | Residue |
| C | PRO68 |
| C | ILE71 |
| C | ILE73 |
| site_id | AE8 |
| Number of Residues | 1 |
| Details | binding site for residue LMT C 407 |
| Chain | Residue |
| A | LMT408 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue SIN C 408 |
| Chain | Residue |
| C | ARG77 |
| C | ARG85 |
| C | PRO74 |
| C | ILE76 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue PLC D 401 |
| Chain | Residue |
| D | ARG118 |
| D | PHE121 |
| D | TYR194 |
| D | TYR254 |
| D | ASN307 |
| D | PHE315 |
| D | PLC403 |
| site_id | AF2 |
| Number of Residues | 2 |
| Details | binding site for residue PLC D 402 |
| Chain | Residue |
| D | THR214 |
| D | TRP217 |
| site_id | AF3 |
| Number of Residues | 1 |
| Details | binding site for residue PLC D 403 |
| Chain | Residue |
| D | PLC401 |
| site_id | AF4 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 404 |
| Chain | Residue |
| D | PHE78 |
| D | ARG85 |
| site_id | AF5 |
| Number of Residues | 3 |
| Details | binding site for residue NA D 405 |
| Chain | Residue |
| D | ILE71 |
| D | ILE73 |
| D | SIN407 |
| site_id | AF6 |
| Number of Residues | 8 |
| Details | binding site for residue SIN D 407 |
| Chain | Residue |
| D | ILE73 |
| D | PRO74 |
| D | GLU75 |
| D | ILE76 |
| D | ARG85 |
| D | TYR102 |
| D | GLU104 |
| D | NA405 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue PLC E 401 |
| Chain | Residue |
| E | ARG118 |
| E | PHE121 |
| E | TYR194 |
| E | TYR254 |
| E | ASN307 |
| E | PLC403 |
| site_id | AF8 |
| Number of Residues | 2 |
| Details | binding site for residue PLC E 402 |
| Chain | Residue |
| E | THR214 |
| E | TRP217 |
| site_id | AF9 |
| Number of Residues | 1 |
| Details | binding site for residue PLC E 403 |
| Chain | Residue |
| E | PLC401 |
| site_id | AG1 |
| Number of Residues | 2 |
| Details | binding site for residue CL E 404 |
| Chain | Residue |
| E | PHE78 |
| E | ARG85 |
| site_id | AG2 |
| Number of Residues | 3 |
| Details | binding site for residue NA E 405 |
| Chain | Residue |
| E | PRO68 |
| E | ILE71 |
| E | ILE73 |
| site_id | AG3 |
| Number of Residues | 2 |
| Details | binding site for residue LMT E 406 |
| Chain | Residue |
| D | ALA237 |
| E | THR244 |
| site_id | AG4 |
| Number of Residues | 5 |
| Details | binding site for residue SIN E 407 |
| Chain | Residue |
| E | PRO74 |
| E | ARG85 |
| E | ALA87 |
| E | TYR102 |
| E | GLU104 |
| site_id | AG5 |
| Number of Residues | 7 |
| Details | binding site for residue SIN E 408 |
| Chain | Residue |
| D | ILE25 |
| D | PHE42 |
| D | ARG105 |
| D | ASN152 |
| E | ARG77 |
| E | ILE131 |
| E | GLU181 |
| site_id | AG6 |
| Number of Residues | 7 |
| Details | binding site for residue PLC F 401 |
| Chain | Residue |
| F | ARG118 |
| F | PHE121 |
| F | TYR194 |
| F | TYR254 |
| F | ASN307 |
| F | PHE315 |
| F | PLC403 |
| site_id | AG7 |
| Number of Residues | 2 |
| Details | binding site for residue PLC F 402 |
| Chain | Residue |
| F | THR214 |
| F | TRP217 |
| site_id | AG8 |
| Number of Residues | 1 |
| Details | binding site for residue PLC F 403 |
| Chain | Residue |
| F | PLC401 |
| site_id | AG9 |
| Number of Residues | 2 |
| Details | binding site for residue CL F 404 |
| Chain | Residue |
| F | PHE78 |
| F | ARG85 |
| site_id | AH1 |
| Number of Residues | 2 |
| Details | binding site for residue NA F 405 |
| Chain | Residue |
| F | PRO68 |
| F | ILE71 |
| site_id | AH2 |
| Number of Residues | 2 |
| Details | binding site for residue LMT F 407 |
| Chain | Residue |
| G | LMT407 |
| J | LMT406 |
| site_id | AH3 |
| Number of Residues | 10 |
| Details | binding site for residue SIN F 408 |
| Chain | Residue |
| F | ARG77 |
| F | VAL79 |
| F | ILE131 |
| F | LEU176 |
| F | GLU181 |
| J | TYR23 |
| J | ILE25 |
| J | PHE42 |
| J | ARG105 |
| J | ASN152 |
| site_id | AH4 |
| Number of Residues | 5 |
| Details | binding site for residue SIN F 409 |
| Chain | Residue |
| F | ILE73 |
| F | PRO74 |
| F | GLU75 |
| F | ILE76 |
| F | ARG85 |
| site_id | AH5 |
| Number of Residues | 9 |
| Details | binding site for residue SIN G 401 |
| Chain | Residue |
| G | ILE25 |
| G | PHE42 |
| G | ARG105 |
| G | ASN152 |
| H | ARG77 |
| H | ILE131 |
| H | PHE174 |
| H | LEU176 |
| H | GLU181 |
| site_id | AH6 |
| Number of Residues | 7 |
| Details | binding site for residue PLC G 402 |
| Chain | Residue |
| G | ARG118 |
| G | PHE121 |
| G | TYR194 |
| G | TYR254 |
| G | ASN307 |
| G | PHE315 |
| G | PLC404 |
| site_id | AH7 |
| Number of Residues | 2 |
| Details | binding site for residue PLC G 403 |
| Chain | Residue |
| G | THR214 |
| G | TRP217 |
| site_id | AH8 |
| Number of Residues | 1 |
| Details | binding site for residue PLC G 404 |
| Chain | Residue |
| G | PLC402 |
| site_id | AH9 |
| Number of Residues | 2 |
| Details | binding site for residue CL G 405 |
| Chain | Residue |
| G | PHE78 |
| G | ARG85 |
| site_id | AI1 |
| Number of Residues | 2 |
| Details | binding site for residue NA G 406 |
| Chain | Residue |
| G | PRO68 |
| G | ILE71 |
| site_id | AI2 |
| Number of Residues | 2 |
| Details | binding site for residue LMT G 407 |
| Chain | Residue |
| F | LMT407 |
| G | THR244 |
| site_id | AI3 |
| Number of Residues | 8 |
| Details | binding site for residue SIN G 408 |
| Chain | Residue |
| F | ILE25 |
| F | PHE42 |
| F | ARG105 |
| F | ASN152 |
| G | ARG77 |
| G | ILE131 |
| G | LEU176 |
| G | GLU181 |
| site_id | AI4 |
| Number of Residues | 5 |
| Details | binding site for residue SIN G 410 |
| Chain | Residue |
| G | PRO74 |
| G | GLU75 |
| G | ILE76 |
| G | ARG77 |
| G | ARG85 |
| site_id | AI5 |
| Number of Residues | 6 |
| Details | binding site for residue PLC H 401 |
| Chain | Residue |
| H | PHE121 |
| H | TYR194 |
| H | TYR254 |
| H | ASN307 |
| H | PHE315 |
| H | PLC403 |
| site_id | AI6 |
| Number of Residues | 2 |
| Details | binding site for residue PLC H 402 |
| Chain | Residue |
| H | THR214 |
| H | TRP217 |
| site_id | AI7 |
| Number of Residues | 1 |
| Details | binding site for residue PLC H 403 |
| Chain | Residue |
| H | PLC401 |
| site_id | AI8 |
| Number of Residues | 2 |
| Details | binding site for residue CL H 404 |
| Chain | Residue |
| H | PHE78 |
| H | ARG85 |
| site_id | AI9 |
| Number of Residues | 3 |
| Details | binding site for residue CL H 405 |
| Chain | Residue |
| H | SER134 |
| H | ASN139 |
| H | LEU180 |
| site_id | AJ1 |
| Number of Residues | 1 |
| Details | binding site for residue CL H 406 |
| Chain | Residue |
| H | ALA175 |
| site_id | AJ2 |
| Number of Residues | 3 |
| Details | binding site for residue NA H 407 |
| Chain | Residue |
| H | PRO68 |
| H | ILE71 |
| H | ILE73 |
| site_id | AJ3 |
| Number of Residues | 4 |
| Details | binding site for residue SIN H 409 |
| Chain | Residue |
| H | ILE73 |
| H | PRO74 |
| H | ILE76 |
| H | ARG85 |
| site_id | AJ4 |
| Number of Residues | 6 |
| Details | binding site for residue PLC I 401 |
| Chain | Residue |
| I | ARG118 |
| I | PHE121 |
| I | TYR194 |
| I | TYR254 |
| I | ASN307 |
| I | PHE315 |
| site_id | AJ5 |
| Number of Residues | 2 |
| Details | binding site for residue PLC I 402 |
| Chain | Residue |
| I | THR214 |
| I | TRP217 |
| site_id | AJ6 |
| Number of Residues | 2 |
| Details | binding site for residue CL I 404 |
| Chain | Residue |
| I | PHE78 |
| I | ARG85 |
| site_id | AJ7 |
| Number of Residues | 2 |
| Details | binding site for residue NA I 405 |
| Chain | Residue |
| I | ILE71 |
| I | ILE73 |
| site_id | AJ8 |
| Number of Residues | 1 |
| Details | binding site for residue LMT I 406 |
| Chain | Residue |
| I | ALA237 |
| site_id | AJ9 |
| Number of Residues | 8 |
| Details | binding site for residue SIN I 407 |
| Chain | Residue |
| I | ILE25 |
| I | PHE42 |
| I | ARG105 |
| I | ASN152 |
| J | ARG77 |
| J | ILE131 |
| J | LEU176 |
| J | GLU181 |
| site_id | AK1 |
| Number of Residues | 8 |
| Details | binding site for residue SIN I 408 |
| Chain | Residue |
| H | ILE25 |
| H | PHE42 |
| H | ARG105 |
| H | ASN152 |
| I | ARG77 |
| I | ILE131 |
| I | LEU176 |
| I | GLU181 |
| site_id | AK2 |
| Number of Residues | 5 |
| Details | binding site for residue SIN I 409 |
| Chain | Residue |
| I | ILE73 |
| I | PRO74 |
| I | GLU75 |
| I | ILE76 |
| I | ARG85 |
| site_id | AK3 |
| Number of Residues | 6 |
| Details | binding site for residue PLC J 401 |
| Chain | Residue |
| J | ARG118 |
| J | PHE121 |
| J | TYR194 |
| J | TYR254 |
| J | ASN307 |
| J | PLC403 |
| site_id | AK4 |
| Number of Residues | 2 |
| Details | binding site for residue PLC J 402 |
| Chain | Residue |
| J | THR214 |
| J | TRP217 |
| site_id | AK5 |
| Number of Residues | 1 |
| Details | binding site for residue PLC J 403 |
| Chain | Residue |
| J | PLC401 |
| site_id | AK6 |
| Number of Residues | 2 |
| Details | binding site for residue CL J 404 |
| Chain | Residue |
| J | PHE78 |
| J | ARG85 |
| site_id | AK7 |
| Number of Residues | 3 |
| Details | binding site for residue NA J 405 |
| Chain | Residue |
| J | PRO68 |
| J | ILE71 |
| J | ILE73 |
| site_id | AK8 |
| Number of Residues | 2 |
| Details | binding site for residue LMT J 406 |
| Chain | Residue |
| F | LMT407 |
| J | ALA237 |
| site_id | AK9 |
| Number of Residues | 6 |
| Details | binding site for residue SIN J 407 |
| Chain | Residue |
| J | PRO68 |
| J | PRO74 |
| J | ILE76 |
| J | ARG85 |
| J | VAL89 |
| J | TYR102 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 740 |
| Details | Transmembrane: {"description":"Helical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 70 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
