Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HJA

Xray structure of GLIC in complex with glutarate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PLC A 401

Chain	Residue
A	ARG118
A	PHE121
A	TYR254
A	ASN307
A	PHE315
A	PLC403

site_id	AC2
Number of Residues	3
Details	binding site for residue PLC A 402

Chain	Residue
A	TRP217
B	VAL275
B	TYR278

site_id	AC3
Number of Residues	1
Details	binding site for residue PLC A 403

Chain	Residue
A	PLC401

site_id	AC4
Number of Residues	1
Details	binding site for residue CL A 404

Chain	Residue
A	PHE78

site_id	AC5
Number of Residues	2
Details	binding site for residue CL A 405

Chain	Residue
A	ASN139
A	LEU180

site_id	AC6
Number of Residues	2
Details	binding site for residue CL A 408

Chain	Residue
A	PRO74
A	ARG85

site_id	AC7
Number of Residues	7
Details	binding site for residue GUA A 409

Chain	Residue
A	PHE42
A	ARG105
A	ASN152
B	ARG77
B	VAL79
B	ILE131
B	GLU181

site_id	AC8
Number of Residues	6
Details	binding site for residue PLC B 401

Chain	Residue
B	ARG118
B	PHE121
B	TYR194
B	TYR254
B	ASN307
B	PLC403

site_id	AC9
Number of Residues	3
Details	binding site for residue PLC B 402

Chain	Residue
B	TRP217
C	PHE267
C	TYR278

site_id	AD1
Number of Residues	1
Details	binding site for residue PLC B 403

Chain	Residue
B	PLC401

site_id	AD2
Number of Residues	1
Details	binding site for residue CL B 404

Chain	Residue
B	PHE78

site_id	AD3
Number of Residues	3
Details	binding site for residue NA B 405

Chain	Residue
B	PRO68
B	ILE71
B	ILE73

site_id	AD4
Number of Residues	3
Details	binding site for residue D12 B 406

Chain	Residue
B	ALA237
B	ILE240
B	THR244

site_id	AD5
Number of Residues	3
Details	binding site for residue CL B 407

Chain	Residue
B	PRO74
B	ILE76
B	ARG85

site_id	AD6
Number of Residues	7
Details	binding site for residue GUA B 408

Chain	Residue
B	TYR23
B	PHE42
B	ARG105
B	ASN152
C	ARG77
C	ILE131
C	GLU181

site_id	AD7
Number of Residues	2
Details	binding site for residue NA C 401

Chain	Residue
A	HOH515
C	HOH513

site_id	AD8
Number of Residues	7
Details	binding site for residue PLC C 402

Chain	Residue
C	ARG118
C	PHE121
C	TYR194
C	TYR254
C	ASN307
C	PHE315
C	PLC404

site_id	AD9
Number of Residues	3
Details	binding site for residue PLC C 403

Chain	Residue
C	TRP217
D	PHE267
D	TYR278

site_id	AE1
Number of Residues	1
Details	binding site for residue PLC C 404

Chain	Residue
C	PLC402

site_id	AE2
Number of Residues	1
Details	binding site for residue CL C 405

Chain	Residue
C	PHE78

site_id	AE3
Number of Residues	3
Details	binding site for residue NA C 406

Chain	Residue
C	PRO68
C	ILE71
C	ILE73

site_id	AE4
Number of Residues	1
Details	binding site for residue D12 C 407

Chain	Residue
B	ALA237

site_id	AE5
Number of Residues	2
Details	binding site for residue CL C 408

Chain	Residue
C	PRO74
C	ARG85

site_id	AE6
Number of Residues	7
Details	binding site for residue PLC D 401

Chain	Residue
D	ARG118
D	PHE121
D	TYR194
D	TYR254
D	ASN307
D	PHE315
D	PLC403

site_id	AE7
Number of Residues	3
Details	binding site for residue PLC D 402

Chain	Residue
D	TRP217
E	VAL275
E	TYR278

site_id	AE8
Number of Residues	1
Details	binding site for residue PLC D 403

Chain	Residue
D	PLC401

site_id	AE9
Number of Residues	1
Details	binding site for residue CL D 404

Chain	Residue
D	PHE78

site_id	AF1
Number of Residues	1
Details	binding site for residue D12 D 405

Chain	Residue
D	ALA237

site_id	AF2
Number of Residues	7
Details	binding site for residue GUA D 406

Chain	Residue
C	TYR23
C	PHE42
C	ARG105
D	ARG77
D	ILE131
D	LEU176
D	GLU181

site_id	AF3
Number of Residues	6
Details	binding site for residue GUA D 407

Chain	Residue
D	PHE42
D	ARG105
D	ASN152
E	ARG77
E	ILE131
E	GLU181

site_id	AF4
Number of Residues	2
Details	binding site for residue CL D 408

Chain	Residue
D	PRO74
D	ARG85

site_id	AF5
Number of Residues	6
Details	binding site for residue PLC E 401

Chain	Residue
E	TYR194
E	TYR254
E	ASN307
E	PLC402
E	ARG118
E	PHE121

site_id	AF6
Number of Residues	1
Details	binding site for residue PLC E 402

Chain	Residue
E	PLC401

site_id	AF7
Number of Residues	1
Details	binding site for residue CL E 403

Chain	Residue
E	PHE78

site_id	AF8
Number of Residues	3
Details	binding site for residue NA E 404

Chain	Residue
E	PRO68
E	ILE71
E	ILE73

site_id	AF9
Number of Residues	1
Details	binding site for residue D12 E 405

Chain	Residue
E	ALA237

site_id	AG1
Number of Residues	7
Details	binding site for residue GUA E 406

Chain	Residue
A	ARG77
A	ILE131
A	GLU181
E	TYR23
E	PHE42
E	ARG105
E	ASN152

site_id	AG2
Number of Residues	3
Details	binding site for residue CL E 407

Chain	Residue
E	PRO74
E	ILE76
E	ARG85

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	990
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
A	GLN2-GLN193
E	ASN245-MET252
A	ASN245-MET252
B	GLN2-GLN193
B	ASN245-MET252
C	GLN2-GLN193
C	ASN245-MET252
D	GLN2-GLN193
D	ASN245-MET252
E	GLN2-GLN193

site_id	SWS_FT_FI2
Number of Residues	530
Details	TRANSMEM: Helical

Chain	Residue	Details
A	TYR194-PHE216
C	SER220-THR244
C	THR253-VAL281
C	PRO285-PHE317
D	TYR194-PHE216
D	SER220-THR244
D	THR253-VAL281
D	PRO285-PHE317
E	TYR194-PHE216
E	SER220-THR244
E	THR253-VAL281
A	SER220-THR244
E	PRO285-PHE317
A	THR253-VAL281
A	PRO285-PHE317
B	TYR194-PHE216
B	SER220-THR244
B	THR253-VAL281
B	PRO285-PHE317
C	TYR194-PHE216

site_id	SWS_FT_FI3
Number of Residues	20
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	TRP217-THR219
E	GLU282-GLN284
A	GLU282-GLN284
B	TRP217-THR219
B	GLU282-GLN284
C	TRP217-THR219
C	GLU282-GLN284
D	TRP217-THR219
D	GLU282-GLN284
E	TRP217-THR219

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)