Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HIX

Cryo-EM structure of the Trypanosoma brucei mitochondrial ribosome - This entry contains the large mitoribosomal subunit

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A1	0003735	molecular_function	structural constituent of ribosome
A1	0005739	cellular_component	mitochondrion
A1	0005762	cellular_component	mitochondrial large ribosomal subunit
A1	0020023	cellular_component	kinetoplast
A2	0003735	molecular_function	structural constituent of ribosome
A2	0005737	cellular_component	cytoplasm
A2	0005739	cellular_component	mitochondrion
A2	0005761	cellular_component	mitochondrial ribosome
A2	0005762	cellular_component	mitochondrial large ribosomal subunit
A2	0005840	cellular_component	ribosome
A2	0006412	biological_process	translation
A2	0020023	cellular_component	kinetoplast
A2	0031981	cellular_component	nuclear lumen
A2	0032543	biological_process	mitochondrial translation
A2	0097014	cellular_component	ciliary plasm
A2	1990904	cellular_component	ribonucleoprotein complex
A4	0005739	cellular_component	mitochondrion
A4	0020023	cellular_component	kinetoplast
A5	0005634	cellular_component	nucleus
A5	0005737	cellular_component	cytoplasm
A5	0005739	cellular_component	mitochondrion
A5	0020023	cellular_component	kinetoplast
A6	0005739	cellular_component	mitochondrion
A6	0005762	cellular_component	mitochondrial large ribosomal subunit
A6	0005840	cellular_component	ribosome
A6	0020023	cellular_component	kinetoplast
A6	1990904	cellular_component	ribonucleoprotein complex
AB	0016172	molecular_function	antifreeze activity
AB	0050825	molecular_function	ice binding
AE	0003735	molecular_function	structural constituent of ribosome
AE	0005739	cellular_component	mitochondrion
AE	0005762	cellular_component	mitochondrial large ribosomal subunit
AE	0005840	cellular_component	ribosome
AE	0006412	biological_process	translation
AE	1990904	cellular_component	ribonucleoprotein complex
AF	0003735	molecular_function	structural constituent of ribosome
AF	0005840	cellular_component	ribosome
AF	0006412	biological_process	translation
AF	1990904	cellular_component	ribonucleoprotein complex
AI	0003735	molecular_function	structural constituent of ribosome
AI	0005737	cellular_component	cytoplasm
AI	0005739	cellular_component	mitochondrion
AI	0005762	cellular_component	mitochondrial large ribosomal subunit
AI	0005840	cellular_component	ribosome
AI	0006412	biological_process	translation
AI	0020023	cellular_component	kinetoplast
AI	0031981	cellular_component	nuclear lumen
AI	0097014	cellular_component	ciliary plasm
AK	0003735	molecular_function	structural constituent of ribosome
AK	0005737	cellular_component	cytoplasm
AK	0005739	cellular_component	mitochondrion
AK	0005762	cellular_component	mitochondrial large ribosomal subunit
AK	0005840	cellular_component	ribosome
AK	0006412	biological_process	translation
AK	0070180	molecular_function	large ribosomal subunit rRNA binding
AK	1990904	cellular_component	ribonucleoprotein complex
AN	0003729	molecular_function	mRNA binding
AN	0003735	molecular_function	structural constituent of ribosome
AN	0005739	cellular_component	mitochondrion
AN	0005762	cellular_component	mitochondrial large ribosomal subunit
AN	0005840	cellular_component	ribosome
AN	0006412	biological_process	translation
AN	0017148	biological_process	negative regulation of translation
AN	0020023	cellular_component	kinetoplast
AN	1990904	cellular_component	ribonucleoprotein complex
AP	0003735	molecular_function	structural constituent of ribosome
AP	0005737	cellular_component	cytoplasm
AP	0005739	cellular_component	mitochondrion
AP	0005762	cellular_component	mitochondrial large ribosomal subunit
AP	0005840	cellular_component	ribosome
AP	0006412	biological_process	translation
AP	0015934	cellular_component	large ribosomal subunit
AP	1990904	cellular_component	ribonucleoprotein complex
AQ	0003735	molecular_function	structural constituent of ribosome
AQ	0005739	cellular_component	mitochondrion
AQ	0005762	cellular_component	mitochondrial large ribosomal subunit
AQ	0005840	cellular_component	ribosome
AQ	0006412	biological_process	translation
AQ	0019843	molecular_function	rRNA binding
AQ	0020023	cellular_component	kinetoplast
AQ	0032543	biological_process	mitochondrial translation
AQ	0036064	cellular_component	ciliary basal body
AQ	1990904	cellular_component	ribonucleoprotein complex
AR	0000315	cellular_component	organellar large ribosomal subunit
AR	0003735	molecular_function	structural constituent of ribosome
AR	0005739	cellular_component	mitochondrion
AR	0005762	cellular_component	mitochondrial large ribosomal subunit
AR	0005840	cellular_component	ribosome
AR	0006412	biological_process	translation
AR	0015934	cellular_component	large ribosomal subunit
AR	1990904	cellular_component	ribonucleoprotein complex
AT	0005737	cellular_component	cytoplasm
AT	0005739	cellular_component	mitochondrion
AU	0003735	molecular_function	structural constituent of ribosome
AU	0005737	cellular_component	cytoplasm
AU	0005739	cellular_component	mitochondrion
AU	0005761	cellular_component	mitochondrial ribosome
AU	0005762	cellular_component	mitochondrial large ribosomal subunit
AU	0005840	cellular_component	ribosome
AU	0006412	biological_process	translation
AU	0019843	molecular_function	rRNA binding
AU	0020023	cellular_component	kinetoplast
AU	1990904	cellular_component	ribonucleoprotein complex
AV	0003723	molecular_function	RNA binding
AV	0003735	molecular_function	structural constituent of ribosome
AV	0005840	cellular_component	ribosome
AV	0006412	biological_process	translation
AW	0003735	molecular_function	structural constituent of ribosome
AW	0005840	cellular_component	ribosome
AW	0006412	biological_process	translation
AW	0015934	cellular_component	large ribosomal subunit
AW	1990904	cellular_component	ribonucleoprotein complex
AX	0003735	molecular_function	structural constituent of ribosome
AX	0005737	cellular_component	cytoplasm
AX	0005739	cellular_component	mitochondrion
AX	0005762	cellular_component	mitochondrial large ribosomal subunit
AX	0005840	cellular_component	ribosome
AX	0006412	biological_process	translation
AX	1990904	cellular_component	ribonucleoprotein complex
AY	0003723	molecular_function	RNA binding
AY	0003735	molecular_function	structural constituent of ribosome
AY	0005840	cellular_component	ribosome
AY	0006412	biological_process	translation
AY	1990904	cellular_component	ribonucleoprotein complex
Ab	0005739	cellular_component	mitochondrion
Ab	0005762	cellular_component	mitochondrial large ribosomal subunit
Ab	0020023	cellular_component	kinetoplast
Af	0005739	cellular_component	mitochondrion
Af	0005762	cellular_component	mitochondrial large ribosomal subunit
Ag	0003735	molecular_function	structural constituent of ribosome
Ag	0005739	cellular_component	mitochondrion
Ag	0005762	cellular_component	mitochondrial large ribosomal subunit
Ag	0005840	cellular_component	ribosome
Ag	0020023	cellular_component	kinetoplast
Ag	0032543	biological_process	mitochondrial translation
Ag	1990904	cellular_component	ribonucleoprotein complex
Aj	0003735	molecular_function	structural constituent of ribosome
Aj	0005739	cellular_component	mitochondrion
Aj	0005762	cellular_component	mitochondrial large ribosomal subunit
Aj	0005840	cellular_component	ribosome
Aj	1990904	cellular_component	ribonucleoprotein complex
Al	0005739	cellular_component	mitochondrion
Al	0005762	cellular_component	mitochondrial large ribosomal subunit
Al	0020023	cellular_component	kinetoplast
Ap	0005739	cellular_component	mitochondrion
Ap	0005762	cellular_component	mitochondrial large ribosomal subunit
Av	0005739	cellular_component	mitochondrion
Av	0005762	cellular_component	mitochondrial large ribosomal subunit
Av	0020023	cellular_component	kinetoplast
BC	0005737	cellular_component	cytoplasm
BC	0005739	cellular_component	mitochondrion
BC	0006631	biological_process	fatty acid metabolic process
BC	0031956	molecular_function	medium-chain fatty acid-CoA ligase activity
BE	0005739	cellular_component	mitochondrion
BE	0005762	cellular_component	mitochondrial large ribosomal subunit
BG	0005737	cellular_component	cytoplasm
BG	0005739	cellular_component	mitochondrion
BG	0005762	cellular_component	mitochondrial large ribosomal subunit
BH	0005737	cellular_component	cytoplasm
BH	0005739	cellular_component	mitochondrion
BH	0005762	cellular_component	mitochondrial large ribosomal subunit
BI	0000963	biological_process	mitochondrial RNA processing
BI	0003723	molecular_function	RNA binding
BI	0005737	cellular_component	cytoplasm
BI	0005739	cellular_component	mitochondrion
BI	0005762	cellular_component	mitochondrial large ribosomal subunit
BI	0020023	cellular_component	kinetoplast
BI	0031019	cellular_component	mitochondrial mRNA editing complex
BI	0043631	biological_process	obsolete RNA polyadenylation
BJ	0005739	cellular_component	mitochondrion
BJ	0005762	cellular_component	mitochondrial large ribosomal subunit
BM	0005737	cellular_component	cytoplasm
BM	0005739	cellular_component	mitochondrion
BM	0005762	cellular_component	mitochondrial large ribosomal subunit
BM	0020023	cellular_component	kinetoplast
BN	0005739	cellular_component	mitochondrion
BN	0005762	cellular_component	mitochondrial large ribosomal subunit
BN	0020023	cellular_component	kinetoplast
BQ	0000413	biological_process	protein peptidyl-prolyl isomerization
BQ	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
BQ	0005634	cellular_component	nucleus
BQ	0005737	cellular_component	cytoplasm
BQ	0005762	cellular_component	mitochondrial large ribosomal subunit
BQ	0006457	biological_process	protein folding
BQ	0016018	molecular_function	cyclosporin A binding
BQ	0016853	molecular_function	isomerase activity
BQ	0031981	cellular_component	nuclear lumen
BQ	0097014	cellular_component	ciliary plasm
BR	0005739	cellular_component	mitochondrion
BR	0020023	cellular_component	kinetoplast
BS	0005737	cellular_component	cytoplasm
BS	0005739	cellular_component	mitochondrion
BS	0005762	cellular_component	mitochondrial large ribosomal subunit
BW	0005739	cellular_component	mitochondrion
BW	0005762	cellular_component	mitochondrial large ribosomal subunit
BW	0010608	biological_process	post-transcriptional regulation of gene expression
BW	0020023	cellular_component	kinetoplast
BX	0046872	molecular_function	metal ion binding
BZ	0000413	biological_process	protein peptidyl-prolyl isomerization
BZ	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
BZ	0005634	cellular_component	nucleus
BZ	0005739	cellular_component	mitochondrion
BZ	0005762	cellular_component	mitochondrial large ribosomal subunit
BZ	0006457	biological_process	protein folding
BZ	0016018	molecular_function	cyclosporin A binding
BZ	0016853	molecular_function	isomerase activity
BZ	0020023	cellular_component	kinetoplast
BZ	0097014	cellular_component	ciliary plasm
Bb	0005737	cellular_component	cytoplasm
Bb	0005739	cellular_component	mitochondrion
Bb	0020023	cellular_component	kinetoplast
Bc	0005739	cellular_component	mitochondrion
Be	0005737	cellular_component	cytoplasm
Be	0005739	cellular_component	mitochondrion
Be	0020023	cellular_component	kinetoplast
Bf	0005739	cellular_component	mitochondrion
Bf	0020023	cellular_component	kinetoplast
Bg	0005739	cellular_component	mitochondrion
Bg	0010608	biological_process	post-transcriptional regulation of gene expression
Bg	0020023	cellular_component	kinetoplast

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A5 100

Chain	Residue
A5	CYS57
A5	CYS60
A5	CYS70
A5	CYS75

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A9 500

Chain	Residue
A9	CYS72
A9	CYS75
A9	CYS88
A9	HIS94

site_id	AC3
Number of Residues	18
Details	binding site for residue NAD Av 301

Chain	Residue
AF	TRP455
AF	MET457
AF	LEU458
AP	GLU270
AP	TYR271
AP	PRO272
AP	MET275
Av	LYS66
Av	ARG68
Av	ARG69
Av	PRO70
Av	MET72
Av	LYS75
Av	TYR127
Av	GLN128
Av	LEU131
BT	LYS93
AF	ASP421

site_id	AC4
Number of Residues	2
Details	binding site for residue MG AA 1201

Chain	Residue
AA	A30
Ba	ASP122

site_id	AC5
Number of Residues	4
Details	binding site for residue MG AA 1203

Chain	Residue
AA	C395
AA	U396
AA	U438
AA	C439

site_id	AC6
Number of Residues	1
Details	binding site for residue MG AA 1204

Chain	Residue
AA	A140

site_id	AC7
Number of Residues	4
Details	binding site for residue MG AA 1205

Chain	Residue
AA	U410
AA	A411
AA	U413
AA	A414

site_id	AC8
Number of Residues	2
Details	binding site for residue MG AA 1206

Chain	Residue
AA	G18
AA	A19

site_id	AC9
Number of Residues	1
Details	binding site for residue MG AA 1207

Chain	Residue
AA	A146

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN BX 201

Chain	Residue
BX	CYS79
BX	CYS82
BX	HIS113
BX	CYS116

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN BX 202

Chain	Residue
BX	CYS119
BX	CYS122
BX	CYS140
BX	CYS143

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN Be 500

Chain	Residue
Be	CYS13
Be	CYS16
Be	CYS63
Be	CYS66

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN Bh 100

Chain	Residue
Bh	CYS6
Bh	CYS9
Bh	CYS32
Bh	CYS35

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	23
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cal..ChvrFrfkqdyeaHkeselH

Chain	Residue	Details
BY	CYS65-HIS79

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. NEEHEFVHQY

Chain	Residue	Details
Bc	ASN59-TYR68

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. AMFeVekDgGFDnFILKR

Chain	Residue	Details
A1	ALA126-ARG143

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)