Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HIW

Cryo-EM structure of the Trypanosoma brucei mitochondrial ribosome - This entry contains the complete small mitoribosomal subunit in complex with mt-IF-3

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
Ca	0005739	cellular_component	mitochondrion
Ca	0005763	cellular_component	mitochondrial small ribosomal subunit
Cb	0005737	cellular_component	cytoplasm
Cb	0005739	cellular_component	mitochondrion
Cb	0005763	cellular_component	mitochondrial small ribosomal subunit
Cb	0097014	cellular_component	ciliary plasm
Cd	0005739	cellular_component	mitochondrion
Cd	0005763	cellular_component	mitochondrial small ribosomal subunit
CE	0003735	molecular_function	structural constituent of ribosome
CE	0005737	cellular_component	cytoplasm
CE	0005739	cellular_component	mitochondrion
CE	0005763	cellular_component	mitochondrial small ribosomal subunit
CE	0005840	cellular_component	ribosome
CE	0006412	biological_process	translation
CF	0005739	cellular_component	mitochondrion
CF	0005763	cellular_component	mitochondrial small ribosomal subunit
Cg	0003735	molecular_function	structural constituent of ribosome
Cg	0005737	cellular_component	cytoplasm
Cg	0005739	cellular_component	mitochondrion
Cg	0005763	cellular_component	mitochondrial small ribosomal subunit
Cg	0005840	cellular_component	ribosome
Cg	0031981	cellular_component	nuclear lumen
Cg	0097014	cellular_component	ciliary plasm
Cg	1990904	cellular_component	ribonucleoprotein complex
CH	0000314	cellular_component	organellar small ribosomal subunit
CH	0003735	molecular_function	structural constituent of ribosome
CH	0005737	cellular_component	cytoplasm
CH	0005739	cellular_component	mitochondrion
CH	0005763	cellular_component	mitochondrial small ribosomal subunit
CH	0005840	cellular_component	ribosome
CH	0006412	biological_process	translation
CH	0020023	cellular_component	kinetoplast
CH	0043229	cellular_component	intracellular organelle
CH	1990904	cellular_component	ribonucleoprotein complex
Ci	0005739	cellular_component	mitochondrion
Ci	0005763	cellular_component	mitochondrial small ribosomal subunit
CI	0003735	molecular_function	structural constituent of ribosome
CI	0005739	cellular_component	mitochondrion
CI	0005763	cellular_component	mitochondrial small ribosomal subunit
CI	0005840	cellular_component	ribosome
CI	0006412	biological_process	translation
CI	1990904	cellular_component	ribonucleoprotein complex
Cj	0005739	cellular_component	mitochondrion
Cj	0005763	cellular_component	mitochondrial small ribosomal subunit
CJ	0005737	cellular_component	cytoplasm
CJ	0005739	cellular_component	mitochondrion
CJ	0005763	cellular_component	mitochondrial small ribosomal subunit
Ck	0000963	biological_process	mitochondrial RNA processing
Ck	0003723	molecular_function	RNA binding
Ck	0005737	cellular_component	cytoplasm
Ck	0005739	cellular_component	mitochondrion
Ck	0031019	cellular_component	mitochondrial mRNA editing complex
Ck	0043631	biological_process	obsolete RNA polyadenylation
Ck	0048255	biological_process	mRNA stabilization
CK	0003735	molecular_function	structural constituent of ribosome
CK	0005739	cellular_component	mitochondrion
CK	0005763	cellular_component	mitochondrial small ribosomal subunit
CK	0005840	cellular_component	ribosome
CK	0006412	biological_process	translation
CK	1990904	cellular_component	ribonucleoprotein complex
Cm	0005737	cellular_component	cytoplasm
Cn	0005739	cellular_component	mitochondrion
Cn	0020023	cellular_component	kinetoplast
CN	0005739	cellular_component	mitochondrion
CN	0005763	cellular_component	mitochondrial small ribosomal subunit
CO	0005739	cellular_component	mitochondrion
CO	0005763	cellular_component	mitochondrial small ribosomal subunit
Cp	0005739	cellular_component	mitochondrion
Cp	0005763	cellular_component	mitochondrial small ribosomal subunit
CP	0005737	cellular_component	cytoplasm
CP	0005739	cellular_component	mitochondrion
CP	0005763	cellular_component	mitochondrial small ribosomal subunit
Cq	0004784	molecular_function	superoxide dismutase activity
Cq	0005739	cellular_component	mitochondrion
Cq	0006801	biological_process	superoxide metabolic process
Cq	0016491	molecular_function	oxidoreductase activity
Cq	0019430	biological_process	removal of superoxide radicals
Cq	0046872	molecular_function	metal ion binding
CQ	0000314	cellular_component	organellar small ribosomal subunit
CQ	0003735	molecular_function	structural constituent of ribosome
CQ	0005737	cellular_component	cytoplasm
CQ	0005739	cellular_component	mitochondrion
CQ	0005763	cellular_component	mitochondrial small ribosomal subunit
CQ	0005840	cellular_component	ribosome
CQ	0006412	biological_process	translation
CQ	1990904	cellular_component	ribonucleoprotein complex
Cr	0004784	molecular_function	superoxide dismutase activity
Cr	0005739	cellular_component	mitochondrion
Cr	0005763	cellular_component	mitochondrial small ribosomal subunit
Cr	0006801	biological_process	superoxide metabolic process
Cr	0019430	biological_process	removal of superoxide radicals
Cr	0046872	molecular_function	metal ion binding
CR	0003723	molecular_function	RNA binding
CR	0005737	cellular_component	cytoplasm
CR	0005739	cellular_component	mitochondrion
CR	0005763	cellular_component	mitochondrial small ribosomal subunit
CR	0043631	biological_process	obsolete RNA polyadenylation
CR	0048255	biological_process	mRNA stabilization
CS	0005739	cellular_component	mitochondrion
CS	0005763	cellular_component	mitochondrial small ribosomal subunit
CU	0005739	cellular_component	mitochondrion
Cv	0003860	molecular_function	3-hydroxyisobutyryl-CoA hydrolase activity
Cv	0004300	molecular_function	enoyl-CoA hydratase activity
Cv	0005737	cellular_component	cytoplasm
Cv	0005739	cellular_component	mitochondrion
Cv	0005763	cellular_component	mitochondrial small ribosomal subunit
Cv	0006635	biological_process	fatty acid beta-oxidation
Cv	0016787	molecular_function	hydrolase activity
CZ	0005739	cellular_component	mitochondrion
DA	0005739	cellular_component	mitochondrion
DA	0005763	cellular_component	mitochondrial small ribosomal subunit
DB	0005654	cellular_component	nucleoplasm
DB	0005737	cellular_component	cytoplasm
DB	0005739	cellular_component	mitochondrion
DB	0005763	cellular_component	mitochondrial small ribosomal subunit
DB	0097014	cellular_component	ciliary plasm
DC	0005739	cellular_component	mitochondrion
DC	0005763	cellular_component	mitochondrial small ribosomal subunit
DD	0000963	biological_process	mitochondrial RNA processing
DD	0005737	cellular_component	cytoplasm
DD	0005739	cellular_component	mitochondrion
DD	0031019	cellular_component	mitochondrial mRNA editing complex
DE	0000963	biological_process	mitochondrial RNA processing
DE	0003723	molecular_function	RNA binding
DE	0005739	cellular_component	mitochondrion
DE	0020023	cellular_component	kinetoplast
DE	0031019	cellular_component	mitochondrial mRNA editing complex
DE	0043631	biological_process	obsolete RNA polyadenylation
DE	0048255	biological_process	mRNA stabilization
DF	0005737	cellular_component	cytoplasm
DF	0005739	cellular_component	mitochondrion
DF	0005763	cellular_component	mitochondrial small ribosomal subunit
DG	0005634	cellular_component	nucleus
DG	0005737	cellular_component	cytoplasm
DG	0005739	cellular_component	mitochondrion
DG	0005763	cellular_component	mitochondrial small ribosomal subunit
DH	0003729	molecular_function	mRNA binding
DH	0005739	cellular_component	mitochondrion
DH	0005763	cellular_component	mitochondrial small ribosomal subunit
DH	0006396	biological_process	RNA processing
DH	0007005	biological_process	mitochondrion organization
DI	0005739	cellular_component	mitochondrion
DI	0005763	cellular_component	mitochondrial small ribosomal subunit
DJ	0005737	cellular_component	cytoplasm
DJ	0005739	cellular_component	mitochondrion
DJ	0005763	cellular_component	mitochondrial small ribosomal subunit
DL	0005739	cellular_component	mitochondrion
DL	0005763	cellular_component	mitochondrial small ribosomal subunit
DM	0005739	cellular_component	mitochondrion
DM	0005763	cellular_component	mitochondrial small ribosomal subunit
DN	0005739	cellular_component	mitochondrion
DN	0005763	cellular_component	mitochondrial small ribosomal subunit
DO	0005739	cellular_component	mitochondrion
DO	0005763	cellular_component	mitochondrial small ribosomal subunit
DO	0009372	biological_process	quorum sensing
DO	0044145	biological_process	modulation of formation of structure involved in a symbiotic process
DP	0005737	cellular_component	cytoplasm
DP	0005763	cellular_component	mitochondrial small ribosomal subunit
DQ	0005737	cellular_component	cytoplasm
DQ	0005739	cellular_component	mitochondrion
DQ	0005829	cellular_component	cytosol
DQ	0010738	biological_process	regulation of protein kinase A signaling
DQ	0034237	molecular_function	protein kinase A regulatory subunit binding
DR	0005739	cellular_component	mitochondrion
DR	0005763	cellular_component	mitochondrial small ribosomal subunit
DS	0005739	cellular_component	mitochondrion
DS	0005763	cellular_component	mitochondrial small ribosomal subunit
DT	0004792	molecular_function	thiosulfate sulfurtransferase activity
DT	0005739	cellular_component	mitochondrion
DT	0005763	cellular_component	mitochondrial small ribosomal subunit
DU	0005739	cellular_component	mitochondrion
DU	0005763	cellular_component	mitochondrial small ribosomal subunit
DV	0005739	cellular_component	mitochondrion
DV	0005763	cellular_component	mitochondrial small ribosomal subunit
DW	0005739	cellular_component	mitochondrion
DW	0005763	cellular_component	mitochondrial small ribosomal subunit
DX	0005739	cellular_component	mitochondrion
DY	0005739	cellular_component	mitochondrion
DY	0005763	cellular_component	mitochondrial small ribosomal subunit
DY	0020023	cellular_component	kinetoplast
DZ	0005739	cellular_component	mitochondrion
DZ	0005763	cellular_component	mitochondrial small ribosomal subunit

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN DA 1801

Chain	Residue
DA	CYS291
DA	CYS294
DA	CYS304
DA	HIS323

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN DS 1001

Chain	Residue
DS	CYS98
DS	CYS101
DS	CYS119
DS	CYS122

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN DS 1002

Chain	Residue
DS	CYS178
DS	CYS211
DS	CYS214
DS	CYS175

site_id	AC4
Number of Residues	11
Details	binding site for residue UTP DJ 401

Chain	Residue
CA	U429
DF	ARG188
DJ	ARG132
DJ	LYS171
DJ	PHE202
DJ	LYS205
DJ	ARG209
DJ	ARG236
DJ	LYS283
DJ	LEU284
DJ	ARG285

site_id	AC5
Number of Residues	2
Details	binding site for residue MG CQ 401

Chain	Residue
CQ	HIS39
Da	HIS12

site_id	AC6
Number of Residues	2
Details	binding site for residue MG Ca 701

Chain	Residue
CH	MET67
Ca	ARG363

site_id	AC7
Number of Residues	24
Details	binding site for residue GTP Cg 501

Chain	Residue
Cg	ARG96
Cg	VAL97
Cg	GLN99
Cg	THR100
Cg	GLY108
Cg	PHE109
Cg	LEU110
Cg	THR151
Cg	GLY152
Cg	CYS153
Cg	GLY154
Cg	LYS155
Cg	SER156
Cg	ALA157
Cg	THR357
Cg	THR358
Cg	ARG359
Cg	ASP360
Cg	PRO452
Cg	GLN453
Cg	MG502
Cg	HOH601
Cg	HOH602
Cg	HOH603

site_id	AC8
Number of Residues	5
Details	binding site for residue MG Cg 502

Chain	Residue
Cg	SER156
Cg	GTP501
Cg	HOH601
Cg	HOH602
Cg	HOH603

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN Cr 501

Chain	Residue
Cr	HIS55
Cr	CYS59
Cr	CYS82
Cr	CYS85

site_id	AD1
Number of Residues	1
Details	binding site for residue MG Cv 1301

Chain	Residue
Cv	ASP30

site_id	AD2
Number of Residues	1
Details	binding site for residue MG CA 701

Chain	Residue
CA	A27

site_id	AD3
Number of Residues	2
Details	binding site for residue MG CA 702

Chain	Residue
CA	U65
CA	A131

site_id	AD4
Number of Residues	2
Details	binding site for residue MG CA 703

Chain	Residue
CA	U65
CA	A133

site_id	AD5
Number of Residues	3
Details	binding site for residue MG CA 704

Chain	Residue
CA	A60
CA	A61
CA	A155

site_id	AD6
Number of Residues	2
Details	binding site for residue MG CA 705

Chain	Residue
CA	A68
CA	A93

site_id	AD7
Number of Residues	1
Details	binding site for residue MG CA 706

Chain	Residue
CA	U69

site_id	AD8
Number of Residues	2
Details	binding site for residue MG CA 707

Chain	Residue
CA	A91
CO	ASN429

site_id	AD9
Number of Residues	2
Details	binding site for residue MG CA 708

Chain	Residue
CA	U142
CA	G147

site_id	AE1
Number of Residues	2
Details	binding site for residue MG CA 709

Chain	Residue
CA	U231
CA	U246

site_id	AE2
Number of Residues	2
Details	binding site for residue MG CA 710

Chain	Residue
CA	C237
CA	U251

site_id	AE3
Number of Residues	2
Details	binding site for residue MG CA 711

Chain	Residue
CA	U338
CA	U339

site_id	AE4
Number of Residues	2
Details	binding site for residue MG CA 712

Chain	Residue
CA	A571
CA	A572

site_id	AE5
Number of Residues	2
Details	binding site for residue MG CA 713

Chain	Residue
CA	U563
CA	U564

site_id	AE6
Number of Residues	2
Details	binding site for residue MG CA 716

Chain	Residue
CA	U592
CA	A593

site_id	AE7
Number of Residues	3
Details	binding site for residue MG CA 718

Chain	Residue
CA	A280
CA	U281
CA	A367

site_id	AE8
Number of Residues	1
Details	binding site for residue MG CA 719

Chain	Residue
CA	U596

site_id	AE9
Number of Residues	1
Details	binding site for residue MG CA 720

Chain	Residue
CA	G159

site_id	AF1
Number of Residues	1
Details	binding site for residue MG CA 721

Chain	Residue
CA	C238

site_id	AF2
Number of Residues	3
Details	binding site for residue MG CA 722

Chain	Residue
CA	A583
CA	G584
CA	U588

site_id	AF3
Number of Residues	6
Details	binding site for residue MG CA 723

Chain	Residue
CA	U588
CA	A590
CA	A591
CA	MG724
CA	G584
CA	A587

site_id	AF4
Number of Residues	5
Details	binding site for residue MG CA 724

Chain	Residue
CA	A583
CA	G584
CA	A591
CA	A604
CA	MG723

site_id	AF5
Number of Residues	3
Details	binding site for residue MG CA 726

Chain	Residue
CA	A222
CA	A224
CA	A225

site_id	AF6
Number of Residues	1
Details	binding site for residue MG CA 727

Chain	Residue
CA	A248

site_id	AF7
Number of Residues	3
Details	binding site for residue MG CA 729

Chain	Residue
CA	A586
CA	U613
Cb	TYR9

site_id	AF8
Number of Residues	2
Details	binding site for residue MG CA 730

Chain	Residue
CA	A386
CA	U387

site_id	AF9
Number of Residues	1
Details	binding site for residue MG CA 731

Chain	Residue
CA	A385

site_id	AG1
Number of Residues	2
Details	binding site for residue MG CA 732

Chain	Residue
CA	A541
Cm	ASP68

site_id	AG2
Number of Residues	3
Details	binding site for residue MG CA 733

Chain	Residue
CA	A76
CA	G78
Cj	ARG10

site_id	AG3
Number of Residues	9
Details	binding site for residue SPD CA 736

Chain	Residue
CA	A452
CA	A453
CA	G454
CA	G466
CA	A467
CA	A468
CA	A469
CJ	MET387
DL	ARG292

site_id	AG4
Number of Residues	5
Details	binding site for residue SPD CA 737

Chain	Residue
CA	U398
CA	A399
CA	A459
CK	GLY19
DL	HIS267

site_id	AG5
Number of Residues	7
Details	binding site for residue SPD CA 738

Chain	Residue
CA	A218
CA	U261
CA	A262
CA	A264
Ca	ARG572
Ca	ASP578
Cp	PRO15

site_id	AG6
Number of Residues	7
Details	binding site for residue SPD CA 739

Chain	Residue
CA	A27
CA	G239
CA	A266
CA	U267
CA	U268
CL	GLY72
Cp	THR12

site_id	AG7
Number of Residues	10
Details	binding site for residue SPM CA 740

Chain	Residue
CA	U66
CA	U67
CA	U95
CA	U96
CA	U97
CA	U126
CA	G127
CA	A128
CA	U129
CQ	THR127

Functional Information from PROSITE/UniProt

site_id	PS00307
Number of Residues	7
Details	LECTIN_LEGUME_BETA Legume lectins beta-chain signature. LTVQLDS

Chain	Residue	Details
DB	LEU797-SER803

site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WInspRGQSwAL

Chain	Residue	Details
DM	TRP186-LEU197

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)