6HH6

Human poly(ADP-ribose) glycohydrolase in complex with ADP-HPM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
A	0005975	biological_process	carbohydrate metabolic process
A	0006282	biological_process	regulation of DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	binding site for residue A3R A 1001

Chain	Residue
A	ILE726
A	TYR795
A	ASN869
A	GLY871
A	CYS872
A	GLY873
A	ALA874
A	PHE875
A	PHE902
A	HOH1119
A	HOH1128
A	GLU727
A	HOH1144
A	HOH1205
A	HOH1258
A	HOH1265
A	HOH1283
A	HOH1303
A	HOH1398
A	HOH1447
A	PHE738
A	ASN740
A	GLY745
A	VAL753
A	GLN754
A	GLU755
A	GLU756

---

site_id	AC2
Number of Residues	8
Details	binding site for residue SO4 A 1002

Chain	Residue
A	ARG535
A	TYR564
A	PRO643
A	ARG644
A	ASN646
A	ARG941
A	ASN942
A	HOH1105

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 1003

Chain	Residue
A	TRP506
A	LYS512
A	ARG644
A	HOH1336

---

site_id	AC4
Number of Residues	7
Details	binding site for residue SO4 A 1004

Chain	Residue
A	TYR521
A	ARG535
A	LYS559
A	TYR560
A	ASN561
A	VAL562
A	HOH1281

---

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 A 1005

Chain	Residue
A	ARG475
A	SER477
A	ALA478

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	185
Details	Region: {"description":"Catalytic","evidences":[{"source":"PubMed","id":"23251397","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"23251397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22673905","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23251397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22673905","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23251397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22673905","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23251397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30472116","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9QYM2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Sterically intereferes with binding of internal ADP-D-ribose moieties of poly(ADP-ribose) to preferntially bind terminal moieties and drive exo-glycohydrolitic action","evidences":[{"source":"PubMed","id":"23917065","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---