6HGM

Crystal structure of Alpha1-antichymotrypsin variant NewBG-III-allo: an allosterically controlled new binding globulin with an unprecedentedly high ligand release efficacy

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0006953	biological_process	acute-phase response
A	0006954	biological_process	inflammatory response
A	0019216	biological_process	regulation of lipid metabolic process
A	0030277	biological_process	maintenance of gastrointestinal epithelium
A	0030414	molecular_function	peptidase inhibitor activity
A	0031012	cellular_component	extracellular matrix
A	0031093	cellular_component	platelet alpha granule lumen
A	0034097	biological_process	response to cytokine
A	0034774	cellular_component	secretory granule lumen
A	0035578	cellular_component	azurophil granule lumen
A	0070062	cellular_component	extracellular exosome
A	0072562	cellular_component	blood microparticle

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CL A 401

Chain	Residue
A	ARG349
B	MET378
B	MET391
B	SER392

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CL A 402

Chain	Residue
A	LYS174
A	ASP175
A	LYS356
A	HOH785

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CL A 403

Chain	Residue
A	ASN70
A	LEU73
A	SER237
A	LYS260
A	HIS69

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CA A 404

Chain	Residue
A	ASP259
A	GLU263
A	EDO407
A	HOH512
A	HOH562
A	HOH589

---

site_id	AC5
Number of Residues	7
Details	binding site for residue CA A 405

Chain	Residue
A	ASN70
A	ASP257
A	HOH616
A	HOH790
A	HOH796
A	HOH802
A	HOH806

---

site_id	AC6
Number of Residues	7
Details	binding site for residue CA A 406

Chain	Residue
A	GLU86
A	HOH580
A	HOH623
A	HOH719
A	HOH795
A	HOH833
A	HOH885

---

site_id	AC7
Number of Residues	8
Details	binding site for residue EDO A 407

Chain	Residue
A	GLU89
A	ASP259
A	LYS260
A	GLU263
A	CA404
A	HOH512
A	HOH589
A	HOH622

---

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO A 408

Chain	Residue
A	GLU89
A	ALA90
A	HIS93
A	ARG129
A	ASP133
A	HOH528
A	HOH656

---

Functional Information from PROSITE/UniProt

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. VRFNRPFLMiI

Chain	Residue	Details
B	VAL370-ILE380

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	DNA binding: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---