6HDU
Crystal structure of human Rab38 in complex with GTP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005802 | cellular_component | trans-Golgi network |
| A | 0016192 | biological_process | vesicle-mediated transport |
| A | 0031982 | cellular_component | vesicle |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005802 | cellular_component | trans-Golgi network |
| B | 0016192 | biological_process | vesicle-mediated transport |
| B | 0031982 | cellular_component | vesicle |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005794 | cellular_component | Golgi apparatus |
| C | 0005802 | cellular_component | trans-Golgi network |
| C | 0016192 | biological_process | vesicle-mediated transport |
| C | 0031982 | cellular_component | vesicle |
| D | 0003924 | molecular_function | GTPase activity |
| D | 0005525 | molecular_function | GTP binding |
| D | 0005794 | cellular_component | Golgi apparatus |
| D | 0005802 | cellular_component | trans-Golgi network |
| D | 0016192 | biological_process | vesicle-mediated transport |
| D | 0031982 | cellular_component | vesicle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue GTP A 900 |
| Chain | Residue |
| A | LEU18 |
| A | SER36 |
| A | TYR38 |
| A | ALA40 |
| A | THR41 |
| A | GLY68 |
| A | ASN127 |
| A | LYS128 |
| A | ASP130 |
| A | GLN131 |
| A | SER159 |
| A | GLY19 |
| A | ALA160 |
| A | LYS161 |
| A | MG901 |
| A | HOH1010 |
| A | HOH1020 |
| A | HOH1037 |
| A | HOH1074 |
| A | VAL20 |
| A | GLY21 |
| A | LYS22 |
| A | THR23 |
| A | SER24 |
| A | PHE34 |
| A | SER35 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 901 |
| Chain | Residue |
| A | THR23 |
| A | THR41 |
| A | GTP900 |
| A | HOH1010 |
| A | HOH1020 |
| site_id | AC3 |
| Number of Residues | 26 |
| Details | binding site for residue GTP B 900 |
| Chain | Residue |
| B | LEU18 |
| B | GLY19 |
| B | VAL20 |
| B | GLY21 |
| B | LYS22 |
| B | THR23 |
| B | SER24 |
| B | PHE34 |
| B | SER35 |
| B | SER36 |
| B | TYR38 |
| B | ALA40 |
| B | THR41 |
| B | GLY68 |
| B | ASN127 |
| B | LYS128 |
| B | ASP130 |
| B | GLN131 |
| B | SER159 |
| B | ALA160 |
| B | LYS161 |
| B | MG901 |
| B | HOH1027 |
| B | HOH1030 |
| B | HOH1039 |
| B | HOH1071 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 901 |
| Chain | Residue |
| B | THR23 |
| B | THR41 |
| B | GTP900 |
| B | HOH1027 |
| B | HOH1030 |
| site_id | AC5 |
| Number of Residues | 26 |
| Details | binding site for residue GTP C 900 |
| Chain | Residue |
| C | LEU18 |
| C | GLY19 |
| C | VAL20 |
| C | GLY21 |
| C | LYS22 |
| C | THR23 |
| C | SER24 |
| C | PHE34 |
| C | SER35 |
| C | SER36 |
| C | TYR38 |
| C | THR41 |
| C | GLY68 |
| C | ASN127 |
| C | LYS128 |
| C | ASP130 |
| C | GLN131 |
| C | SER159 |
| C | ALA160 |
| C | LYS161 |
| C | MG901 |
| C | HOH1021 |
| C | HOH1035 |
| C | HOH1056 |
| C | HOH1057 |
| C | HOH1086 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 901 |
| Chain | Residue |
| C | THR23 |
| C | THR41 |
| C | GTP900 |
| C | HOH1021 |
| C | HOH1035 |
| site_id | AC7 |
| Number of Residues | 25 |
| Details | binding site for residue GTP D 900 |
| Chain | Residue |
| D | SER24 |
| D | PHE34 |
| D | SER35 |
| D | SER36 |
| D | TYR38 |
| D | THR41 |
| D | GLY68 |
| D | ASN127 |
| D | LYS128 |
| D | ASP130 |
| D | SER159 |
| D | ALA160 |
| D | LYS161 |
| D | MG901 |
| D | HOH1015 |
| D | HOH1028 |
| D | HOH1039 |
| D | HOH1044 |
| D | HOH1110 |
| D | LEU18 |
| D | GLY19 |
| D | VAL20 |
| D | GLY21 |
| D | LYS22 |
| D | THR23 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 901 |
| Chain | Residue |
| D | THR23 |
| D | THR41 |
| D | GTP900 |
| D | HOH1015 |
| D | HOH1028 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 32 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGVGKTSIIKrYvhqnfsshyratigvd..FALK |
| Chain | Residue | Details |
| A | LEU18-LYS49 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 56 |
| Details | Motif: {"description":"Switch 1","evidences":[{"source":"UniProtKB","id":"Q13637","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 52 |
| Details | Motif: {"description":"Switch 2","evidences":[{"source":"UniProtKB","id":"Q13637","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 64 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2019","submissionDatabase":"PDB data bank","title":"Structure of the human RAB38 in complex with GTP.","authors":["Diaz-Saez L.","a Jung S.","Huber K.","von Delft F.","Arrowsmith C.H.","Edwards A.","Bountra C."]}},{"source":"PDB","id":"6S5H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
