6HDP

Human DYRK2 bound to Scorzodihydrostilbene A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue FZ5 A 501

Chain	Residue
A	ILE155
A	SER232
A	MET233
A	ASN234
A	GLU237
A	LEU282
A	ILE294
A	ASP295
A	HOH657
A	HOH735
A	VAL163
A	ALA176
A	LYS178
A	GLU193
A	PHE228
A	GLU229
A	LEU230
A	LEU231

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site_id	AC2
Number of Residues	2
Details	binding site for residue NA A 502

Chain	Residue
A	HOH694
A	HOH694

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGSFGQVVkAydhkvhqh..........VALK

Chain	Residue	Details
A	ILE155-LYS178

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHcDLKpeNILL

Chain	Residue	Details
A	ILE271-LEU283

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	LEU348

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	PHE228
A	LEU251
A	TYR301

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by ATM => ECO:0000269|PubMed:19965871

Chain	Residue	Details
A	PRO106

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by MAP3K10 => ECO:0000269|PubMed:18455992

Chain	Residue	Details
A	ASN381

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:22998443

Chain	Residue	Details
A	PHE382

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine; by ATM => ECO:0000269|PubMed:19965871

Chain	Residue	Details
A	CYS442

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAP3K10 => ECO:0000269|PubMed:18455992

Chain	Residue	Details
A	VAL449

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