6HD7

Cryo-EM structure of the ribosome-NatA complex

This is a large structure.
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Functional Information from GO Data

ChainGOidnamespacecontents
u0031415cellular_componentNatA complex
u0042802molecular_functionidentical protein binding
u1990190molecular_functionpeptide-glutamate-N-acetyltransferase activity
u1990189molecular_functionpeptide-serine-N-acetyltransferase activity
u0016573biological_processhistone acetylation
u0018002biological_processN-terminal peptidyl-glutamic acid acetylation
u0017198biological_processN-terminal peptidyl-serine acetylation
u0006474biological_processN-terminal protein amino acid acetylation
u0061606biological_processN-terminal protein amino acid propionylation
t0005737cellular_componentcytoplasm
t0005739cellular_componentmitochondrion
t0031415cellular_componentNatA complex
t0043022molecular_functionribosome binding
t0017196biological_processN-terminal peptidyl-methionine acetylation
t0006474biological_processN-terminal protein amino acid acetylation
v0031415cellular_componentNatA complex
v0004596molecular_functionpeptide alpha-N-acetyltransferase activity
v0006474biological_processN-terminal protein amino acid acetylation
s0022625cellular_componentcytosolic large ribosomal subunit
s0003735molecular_functionstructural constituent of ribosome
s0002181biological_processcytoplasmic translation
s0000027biological_processribosomal large subunit assembly
s0006415biological_processtranslational termination
M0022625cellular_componentcytosolic large ribosomal subunit
M0005634cellular_componentnucleus
M0019843molecular_functionrRNA binding
M0003735molecular_functionstructural constituent of ribosome
M0002181biological_processcytoplasmic translation
M0000027biological_processribosomal large subunit assembly
N0022625cellular_componentcytosolic large ribosomal subunit
N0003735molecular_functionstructural constituent of ribosome
N0002181biological_processcytoplasmic translation
O0022625cellular_componentcytosolic large ribosomal subunit
O0003723molecular_functionRNA binding
O0003735molecular_functionstructural constituent of ribosome
O0002181biological_processcytoplasmic translation
O0016236biological_processmacroautophagy
O0042273biological_processribosomal large subunit biogenesis
P0022625cellular_componentcytosolic large ribosomal subunit
P0003723molecular_functionRNA binding
P0003735molecular_functionstructural constituent of ribosome
P0002181biological_processcytoplasmic translation
Q0022625cellular_componentcytosolic large ribosomal subunit
Q0005840cellular_componentribosome
Q0003729molecular_functionmRNA binding
Q0003723molecular_functionRNA binding
Q0003735molecular_functionstructural constituent of ribosome
Q0002181biological_processcytoplasmic translation
Q0017148biological_processnegative regulation of translation
R0005737cellular_componentcytoplasm
R0022625cellular_componentcytosolic large ribosomal subunit
R0030687cellular_componentpreribosome, large subunit precursor
R0003735molecular_functionstructural constituent of ribosome
R0000448biological_processcleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
R0002181biological_processcytoplasmic translation
S0022625cellular_componentcytosolic large ribosomal subunit
S0003735molecular_functionstructural constituent of ribosome
S0002181biological_processcytoplasmic translation
T0022625cellular_componentcytosolic large ribosomal subunit
T0003723molecular_functionRNA binding
T0003735molecular_functionstructural constituent of ribosome
T0002181biological_processcytoplasmic translation
U0022625cellular_componentcytosolic large ribosomal subunit
U0003735molecular_functionstructural constituent of ribosome
U0002181biological_processcytoplasmic translation
V0022625cellular_componentcytosolic large ribosomal subunit
V0003735molecular_functionstructural constituent of ribosome
V0002181biological_processcytoplasmic translation
W0022625cellular_componentcytosolic large ribosomal subunit
W0003723molecular_functionRNA binding
W0003735molecular_functionstructural constituent of ribosome
W0002181biological_processcytoplasmic translation
X0022625cellular_componentcytosolic large ribosomal subunit
X0070180molecular_functionlarge ribosomal subunit rRNA binding
X0003735molecular_functionstructural constituent of ribosome
X0002181biological_processcytoplasmic translation
Y0022625cellular_componentcytosolic large ribosomal subunit
Y0003723molecular_functionRNA binding
Y0003735molecular_functionstructural constituent of ribosome
Y1902626biological_processassembly of large subunit precursor of preribosome
Y0002181biological_processcytoplasmic translation
Y0000027biological_processribosomal large subunit assembly
Y0006412biological_processtranslation
Z0022625cellular_componentcytosolic large ribosomal subunit
Z0030687cellular_componentpreribosome, large subunit precursor
Z0003723molecular_functionRNA binding
Z0019843molecular_functionrRNA binding
Z0003735molecular_functionstructural constituent of ribosome
Z0002181biological_processcytoplasmic translation
Z0000027biological_processribosomal large subunit assembly
a0022625cellular_componentcytosolic large ribosomal subunit
a0003723molecular_functionRNA binding
a0003735molecular_functionstructural constituent of ribosome
a0002181biological_processcytoplasmic translation
a0042273biological_processribosomal large subunit biogenesis
b0022625cellular_componentcytosolic large ribosomal subunit
b0003735molecular_functionstructural constituent of ribosome
b0002181biological_processcytoplasmic translation
c0022625cellular_componentcytosolic large ribosomal subunit
c0005634cellular_componentnucleus
c0003723molecular_functionRNA binding
c0003735molecular_functionstructural constituent of ribosome
c0002181biological_processcytoplasmic translation
d0005737cellular_componentcytoplasm
d0022625cellular_componentcytosolic large ribosomal subunit
d0003735molecular_functionstructural constituent of ribosome
d0002181biological_processcytoplasmic translation
E0022625cellular_componentcytosolic large ribosomal subunit
E0019843molecular_functionrRNA binding
E0003735molecular_functionstructural constituent of ribosome
E0002181biological_processcytoplasmic translation
e0005737cellular_componentcytoplasm
e0022625cellular_componentcytosolic large ribosomal subunit
e0030627molecular_functionpre-mRNA 5'-splice site binding
e0003723molecular_functionRNA binding
e0003735molecular_functionstructural constituent of ribosome
e0002181biological_processcytoplasmic translation
e0048025biological_processnegative regulation of mRNA splicing, via spliceosome
e0006364biological_processrRNA processing
f0022625cellular_componentcytosolic large ribosomal subunit
f0003735molecular_functionstructural constituent of ribosome
f0002181biological_processcytoplasmic translation
f0006450biological_processregulation of translational fidelity
g0022625cellular_componentcytosolic large ribosomal subunit
g0003735molecular_functionstructural constituent of ribosome
g0002181biological_processcytoplasmic translation
h0022625cellular_componentcytosolic large ribosomal subunit
h0003735molecular_functionstructural constituent of ribosome
h0002181biological_processcytoplasmic translation
h0042273biological_processribosomal large subunit biogenesis
i0022625cellular_componentcytosolic large ribosomal subunit
i0030687cellular_componentpreribosome, large subunit precursor
i0003735molecular_functionstructural constituent of ribosome
i0002181biological_processcytoplasmic translation
i0042254biological_processribosome biogenesis
j0022625cellular_componentcytosolic large ribosomal subunit
j0030687cellular_componentpreribosome, large subunit precursor
j0003729molecular_functionmRNA binding
j0003735molecular_functionstructural constituent of ribosome
j0002181biological_processcytoplasmic translation
j0000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
k0022625cellular_componentcytosolic large ribosomal subunit
k0003723molecular_functionRNA binding
k0003735molecular_functionstructural constituent of ribosome
k0002181biological_processcytoplasmic translation
l0022625cellular_componentcytosolic large ribosomal subunit
l0030687cellular_componentpreribosome, large subunit precursor
l0046872molecular_functionmetal ion binding
l0019843molecular_functionrRNA binding
l0003735molecular_functionstructural constituent of ribosome
l0000448biological_processcleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
l0002181biological_processcytoplasmic translation
m0022625cellular_componentcytosolic large ribosomal subunit
m0003735molecular_functionstructural constituent of ribosome
m0002181biological_processcytoplasmic translation
n0022625cellular_componentcytosolic large ribosomal subunit
n0003735molecular_functionstructural constituent of ribosome
n0002181biological_processcytoplasmic translation
F0022625cellular_componentcytosolic large ribosomal subunit
F0003735molecular_functionstructural constituent of ribosome
F1990145biological_processmaintenance of translational fidelity
F0000027biological_processribosomal large subunit assembly
F0006364biological_processrRNA processing
o0005737cellular_componentcytoplasm
o0022625cellular_componentcytosolic large ribosomal subunit
o0005634cellular_componentnucleus
o0031386molecular_functionprotein tag
o0003735molecular_functionstructural constituent of ribosome
o0031625molecular_functionubiquitin protein ligase binding
o0002181biological_processcytoplasmic translation
o0019941biological_processmodification-dependent protein catabolic process
o0016567biological_processprotein ubiquitination
o0000027biological_processribosomal large subunit assembly
o0000055biological_processribosomal large subunit export from nucleus
o0042254biological_processribosome biogenesis
D0022625cellular_componentcytosolic large ribosomal subunit
D0046872molecular_functionmetal ion binding
D0003735molecular_functionstructural constituent of ribosome
D0002181biological_processcytoplasmic translation
C0022625cellular_componentcytosolic large ribosomal subunit
C0003735molecular_functionstructural constituent of ribosome
C0002181biological_processcytoplasmic translation
C0046898biological_processresponse to cycloheximide
G0022625cellular_componentcytosolic large ribosomal subunit
G0005634cellular_componentnucleus
G0003723molecular_functionRNA binding
G0003735molecular_functionstructural constituent of ribosome
G0002181biological_processcytoplasmic translation
H0022625cellular_componentcytosolic large ribosomal subunit
H0005634cellular_componentnucleus
H0008097molecular_function5S rRNA binding
H0003735molecular_functionstructural constituent of ribosome
H0002181biological_processcytoplasmic translation
H0000027biological_processribosomal large subunit assembly
I0022625cellular_componentcytosolic large ribosomal subunit
I0003723molecular_functionRNA binding
I0003735molecular_functionstructural constituent of ribosome
I0002181biological_processcytoplasmic translation
I0000027biological_processribosomal large subunit assembly
J0005737cellular_componentcytoplasm
J0022625cellular_componentcytosolic large ribosomal subunit
J0003735molecular_functionstructural constituent of ribosome
J0002181biological_processcytoplasmic translation
J0000470biological_processmaturation of LSU-rRNA
J0000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J0042273biological_processribosomal large subunit biogenesis
K0022625cellular_componentcytosolic large ribosomal subunit
K0003723molecular_functionRNA binding
K0003735molecular_functionstructural constituent of ribosome
K0002181biological_processcytoplasmic translation
K0000470biological_processmaturation of LSU-rRNA
L0022625cellular_componentcytosolic large ribosomal subunit
L0019843molecular_functionrRNA binding
L0003735molecular_functionstructural constituent of ribosome
L0002181biological_processcytoplasmic translation
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC18binding site for residue 3HE 1 3401
ChainResidue
1G92
1C93
1U2763
1C2764
1C2765
1G2793
1G2794
CPRO56

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
3HE_6hd7_1_3401114-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione binding site
ChainResidueligand
1G92-C933HE: 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione
1U2763-C27653HE: 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione
1G2793-G27943HE: 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione
1A28013HE: 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione
CLYS55-PRO563HE: 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione
CPHE583HE: 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails