6HD0

Common mode of remodeling AAA ATPases p97/CDC48 by their disassembly cofactors ASPL/PUX1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
B	0005524	molecular_function	ATP binding
B	0016887	molecular_function	ATP hydrolysis activity
C	0005524	molecular_function	ATP binding
C	0016887	molecular_function	ATP hydrolysis activity
D	0005737	cellular_component	cytoplasm
D	0032984	biological_process	protein-containing complex disassembly
D	0035265	biological_process	organ growth
D	0051117	molecular_function	ATPase binding
E	0005737	cellular_component	cytoplasm
E	0032984	biological_process	protein-containing complex disassembly
E	0035265	biological_process	organ growth
E	0051117	molecular_function	ATPase binding
F	0005737	cellular_component	cytoplasm
F	0032984	biological_process	protein-containing complex disassembly
F	0035265	biological_process	organ growth
F	0051117	molecular_function	ATPase binding
G	0005737	cellular_component	cytoplasm
G	0032984	biological_process	protein-containing complex disassembly
G	0035265	biological_process	organ growth
G	0051117	molecular_function	ATPase binding
I	0005737	cellular_component	cytoplasm
I	0032984	biological_process	protein-containing complex disassembly
I	0035265	biological_process	organ growth
I	0051117	molecular_function	ATPase binding
K	0005737	cellular_component	cytoplasm
K	0032984	biological_process	protein-containing complex disassembly
K	0035265	biological_process	organ growth
K	0051117	molecular_function	ATPase binding
T	0005524	molecular_function	ATP binding
T	0016887	molecular_function	ATP hydrolysis activity
U	0005524	molecular_function	ATP binding
U	0016887	molecular_function	ATP hydrolysis activity
V	0005524	molecular_function	ATP binding
V	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue ADP B 501

Chain	Residue
B	ILE206
C	ARG359
B	GLY207
B	THR249
B	GLY250
B	LYS251
B	THR252
B	LEU253
B	HIS384
B	ALA409

---

site_id	AC2
Number of Residues	11
Details	binding site for residue ADP T 501

Chain	Residue
T	GLY207
T	GLY248
T	THR249
T	GLY250
T	LYS251
T	THR252
T	LEU253
T	HIS384
T	ALA409
U	ARG359
U	PHE360

---

site_id	AC3
Number of Residues	8
Details	binding site for residue ADP U 501

Chain	Residue
U	GLY207
U	GLY248
U	THR249
U	GLY250
U	HIS384
U	ALA409
U	ALA412
V	ARG359

---

site_id	AC4
Number of Residues	10
Details	binding site for residue ADP V 501

Chain	Residue
A	ARG359
V	ASP205
V	ILE206
V	GLY207
V	THR249
V	GLY250
V	THR252
V	LEU253
V	HIS384
V	ALA409

---

site_id	AC5
Number of Residues	9
Details	binding site for residue ADP A 501

Chain	Residue
A	GLY207
A	GLY248
A	THR249
A	GLY250
A	LYS251
A	THR252
A	ILE380
A	HIS384
B	ARG359

---

site_id	AC6
Number of Residues	10
Details	binding site for residue ADP C 501

Chain	Residue
C	ASP205
C	ILE206
C	GLY207
C	THR249
C	GLY250
C	THR252
C	LEU253
C	HIS384
C	ALA409
T	ARG359

---

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. ViVMaATNrpnsIDpALr.R

Chain	Residue	Details
B	VAL341-ARG359

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:20512113

Chain	Residue	Details
B	PRO247
V	PRO247
V	ASN348
V	HIS384
A	PRO247
A	ASN348
A	HIS384
C	PRO247
C	ASN348
C	HIS384
B	ASN348
B	HIS384
T	PRO247
T	ASN348
T	HIS384
U	PRO247
U	ASN348
U	HIS384

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: N-acetylalanine => ECO:0000269|Ref.9, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:25944712

Chain	Residue	Details
B	ALA2
T	ALA2
U	ALA2
V	ALA2
A	ALA2
C	ALA2

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER3
T	SER3
U	SER3
V	SER3
A	SER3
C	SER3

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER7
V	SER7
V	SER13
V	SER462
A	SER7
A	SER13
A	SER462
C	SER7
C	SER13
C	SER462
B	SER13
B	SER462
T	SER7
T	SER13
T	SER462
U	SER7
U	SER13
U	SER462

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
B	SER37
T	SER37
U	SER37
V	SER37
A	SER37
C	SER37

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: N6,N6,N6-trimethyllysine; by VCPKMT => ECO:0000269|PubMed:22948820, ECO:0000269|PubMed:23349634

Chain	Residue	Details
B	LYS315
T	LYS315
U	LYS315
V	LYS315
A	LYS315
C	LYS315

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
B	THR436
T	THR436
U	THR436
V	THR436
A	THR436
C	THR436

---

site_id	SWS_FT_FI8
Number of Residues	18
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
B	LYS8
V	LYS8
V	LYS18
A	LYS8
A	LYS18
C	LYS8
C	LYS18
B	LYS18
T	LYS8
T	LYS18
U	LYS8
U	LYS18

---