6HD0

Common mode of remodeling AAA ATPases p97/CDC48 by their disassembly cofactors ASPL/PUX1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
B	0005524	molecular_function	ATP binding
B	0016887	molecular_function	ATP hydrolysis activity
C	0005524	molecular_function	ATP binding
C	0016887	molecular_function	ATP hydrolysis activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0032984	biological_process	protein-containing complex disassembly
D	0035265	biological_process	organ growth
D	0051117	molecular_function	ATPase binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0032984	biological_process	protein-containing complex disassembly
E	0035265	biological_process	organ growth
E	0051117	molecular_function	ATPase binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0032984	biological_process	protein-containing complex disassembly
F	0035265	biological_process	organ growth
F	0051117	molecular_function	ATPase binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0032984	biological_process	protein-containing complex disassembly
G	0035265	biological_process	organ growth
G	0051117	molecular_function	ATPase binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0032984	biological_process	protein-containing complex disassembly
I	0035265	biological_process	organ growth
I	0051117	molecular_function	ATPase binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0032984	biological_process	protein-containing complex disassembly
K	0035265	biological_process	organ growth
K	0051117	molecular_function	ATPase binding
T	0005524	molecular_function	ATP binding
T	0016887	molecular_function	ATP hydrolysis activity
U	0005524	molecular_function	ATP binding
U	0016887	molecular_function	ATP hydrolysis activity
V	0005524	molecular_function	ATP binding
V	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue ADP B 501

Chain	Residue
B	ILE206
C	ARG359
B	GLY207
B	THR249
B	GLY250
B	LYS251
B	THR252
B	LEU253
B	HIS384
B	ALA409

---

site_id	AC2
Number of Residues	11
Details	binding site for residue ADP T 501

Chain	Residue
T	GLY207
T	GLY248
T	THR249
T	GLY250
T	LYS251
T	THR252
T	LEU253
T	HIS384
T	ALA409
U	ARG359
U	PHE360

---

site_id	AC3
Number of Residues	8
Details	binding site for residue ADP U 501

Chain	Residue
U	GLY207
U	GLY248
U	THR249
U	GLY250
U	HIS384
U	ALA409
U	ALA412
V	ARG359

---

site_id	AC4
Number of Residues	10
Details	binding site for residue ADP V 501

Chain	Residue
A	ARG359
V	ASP205
V	ILE206
V	GLY207
V	THR249
V	GLY250
V	THR252
V	LEU253
V	HIS384
V	ALA409

---

site_id	AC5
Number of Residues	9
Details	binding site for residue ADP A 501

Chain	Residue
A	GLY207
A	GLY248
A	THR249
A	GLY250
A	LYS251
A	THR252
A	ILE380
A	HIS384
B	ARG359

---

site_id	AC6
Number of Residues	10
Details	binding site for residue ADP C 501

Chain	Residue
C	ASP205
C	ILE206
C	GLY207
C	THR249
C	GLY250
C	THR252
C	LEU253
C	HIS384
C	ALA409
T	ARG359

---

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. ViVMaATNrpnsIDpALr.R

Chain	Residue	Details
B	VAL341-ARG359

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20512113","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"N6,N6,N6-trimethyllysine; by VCPKMT","evidences":[{"source":"PubMed","id":"22948820","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23349634","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---