6HCU
Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum bound to a difluoro cyclohexyl chromone ligand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004824 | molecular_function | lysine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004824 | molecular_function | lysine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006430 | biological_process | lysyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue FYB A 601 |
| Chain | Residue |
| A | ARG330 |
| A | GLY556 |
| A | ARG559 |
| A | ILE570 |
| A | TRS606 |
| A | HOH872 |
| A | HOH909 |
| A | HOH1040 |
| A | GLU332 |
| A | THR337 |
| A | HIS338 |
| A | ASN339 |
| A | PHE342 |
| A | GLU500 |
| A | GLY554 |
| A | LEU555 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue LYS A 602 |
| Chain | Residue |
| A | LYS321 |
| A | TRP349 |
| A | ALA350 |
| A | TYR351 |
| A | ALA352 |
| A | HOH716 |
| A | HOH748 |
| A | HOH1203 |
| B | LYS105 |
| B | GLU107 |
| B | ARG108 |
| B | HOH727 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 603 |
| Chain | Residue |
| A | ARG235 |
| A | HOH703 |
| A | HOH1137 |
| B | HOH954 |
| B | HOH1044 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue HIS A 604 |
| Chain | Residue |
| A | HIS435 |
| A | HIS455 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue TRS A 605 |
| Chain | Residue |
| A | ARG262 |
| A | ILE325 |
| A | HOH749 |
| A | HOH793 |
| B | ARG262 |
| B | GLU272 |
| B | GLU274 |
| B | ILE325 |
| B | HOH848 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue TRS A 606 |
| Chain | Residue |
| A | ALA306 |
| A | GLU308 |
| A | GLU346 |
| A | TYR348 |
| A | ASN503 |
| A | TYR505 |
| A | GLY554 |
| A | FYB601 |
| A | HOH902 |
| A | HOH906 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | binding site for residue FYB B 601 |
| Chain | Residue |
| B | ARG330 |
| B | THR337 |
| B | HIS338 |
| B | ASN339 |
| B | PHE342 |
| B | GLU500 |
| B | GLY554 |
| B | LEU555 |
| B | GLY556 |
| B | ARG559 |
| B | ILE570 |
| B | TRS603 |
| B | HOH745 |
| B | HOH880 |
| B | HOH978 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue TRS B 602 |
| Chain | Residue |
| A | LYS105 |
| A | ARG108 |
| A | HOH1001 |
| B | LYS321 |
| B | TRP349 |
| B | ALA350 |
| B | TYR351 |
| B | ASP356 |
| B | HOH701 |
| B | HOH704 |
| B | HOH724 |
| B | HOH928 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue TRS B 603 |
| Chain | Residue |
| B | GLU308 |
| B | GLU346 |
| B | TYR348 |
| B | ASN503 |
| B | TYR505 |
| B | LEU553 |
| B | FYB601 |
| B | HOH719 |
