Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6H6K

The structure of the FKR mutant of the archaeal translation initiation factor 2 gamma subunit in complex with GDPCP, obtained in the absence of magnesium salts in the crystallization solution.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0001731	biological_process	formation of translation preinitiation complex
A	0003743	molecular_function	translation initiation factor activity
A	0003746	molecular_function	translation elongation factor activity
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006414	biological_process	translational elongation
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0000049	molecular_function	tRNA binding
B	0000166	molecular_function	nucleotide binding
B	0001731	biological_process	formation of translation preinitiation complex
B	0003743	molecular_function	translation initiation factor activity
B	0003746	molecular_function	translation elongation factor activity
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0006412	biological_process	translation
B	0006413	biological_process	translational initiation
B	0006414	biological_process	translational elongation
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
C	0000049	molecular_function	tRNA binding
C	0000166	molecular_function	nucleotide binding
C	0001731	biological_process	formation of translation preinitiation complex
C	0003743	molecular_function	translation initiation factor activity
C	0003746	molecular_function	translation elongation factor activity
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0006412	biological_process	translation
C	0006413	biological_process	translational initiation
C	0006414	biological_process	translational elongation
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
D	0000049	molecular_function	tRNA binding
D	0000166	molecular_function	nucleotide binding
D	0001731	biological_process	formation of translation preinitiation complex
D	0003743	molecular_function	translation initiation factor activity
D	0003746	molecular_function	translation elongation factor activity
D	0003924	molecular_function	GTPase activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0006412	biological_process	translation
D	0006413	biological_process	translational initiation
D	0006414	biological_process	translational elongation
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
E	0000049	molecular_function	tRNA binding
E	0000166	molecular_function	nucleotide binding
E	0001731	biological_process	formation of translation preinitiation complex
E	0003743	molecular_function	translation initiation factor activity
E	0003746	molecular_function	translation elongation factor activity
E	0003924	molecular_function	GTPase activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0006412	biological_process	translation
E	0006413	biological_process	translational initiation
E	0006414	biological_process	translational elongation
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue GCP A 501

Chain	Residue
A	VAL18
A	LYS150
A	ASP152
A	VAL153
A	SER184
A	ALA185
A	LEU186
A	HOH604
A	HOH606
A	HOH614
A	HOH654
A	ASP19
A	HOH718
A	HOH724
A	HOH744
A	HOH749
A	HOH774
A	HIS20
A	GLY21
A	LYS22
A	THR23
A	THR24
A	GLY96
A	ASN149

site_id	AC2
Number of Residues	6
Details	binding site for residue NA A 502

Chain	Residue
A	MET111
A	HOH675
A	HOH678
A	HOH777
A	HOH808
A	HOH842

site_id	AC3
Number of Residues	6
Details	binding site for residue NA A 503

Chain	Residue
A	THR54
A	THR70
A	HOH662
A	HOH670
A	HOH776
A	HOH815

site_id	AC4
Number of Residues	6
Details	binding site for residue NA A 504

Chain	Residue
A	VAL151
A	VAL154
C	TRP327
C	ASN328
C	HOH708
C	HOH727

site_id	AC5
Number of Residues	21
Details	binding site for residue GCP B 501

Chain	Residue
B	VAL18
B	ASP19
B	HIS20
B	GLY21
B	LYS22
B	THR23
B	THR24
B	GLY96
B	ASN149
B	LYS150
B	ASP152
B	VAL153
B	SER184
B	ALA185
B	LEU186
B	HOH601
B	HOH606
B	HOH627
B	HOH712
B	HOH733
B	HOH753

site_id	AC6
Number of Residues	6
Details	binding site for residue NA B 502

Chain	Residue
B	VAL151
B	VAL154
D	TRP327
D	ASN328
D	HOH717
D	HOH720

site_id	AC7
Number of Residues	6
Details	binding site for residue NA B 503

Chain	Residue
B	THR54
B	THR70
B	HOH649
B	HOH693
B	HOH727
B	HOH776

site_id	AC8
Number of Residues	5
Details	binding site for residue NA B 504

Chain	Residue
B	GLU66
B	TYR68
B	ASP192
B	HOH625
B	HOH769

site_id	AC9
Number of Residues	17
Details	binding site for residue GCP C 501

Chain	Residue
C	VAL18
C	ASP19
C	HIS20
C	GLY21
C	LYS22
C	THR23
C	THR24
C	THR46
C	GLY96
C	ASN149
C	LYS150
C	ASP152
C	VAL153
C	SER184
C	ALA185
C	LEU186
C	HOH681

site_id	AD1
Number of Residues	7
Details	binding site for residue EDO C 502

Chain	Residue
C	SER364
C	VAL386
C	ALA387
C	HOH615
C	HOH623
C	SER314
C	VAL361

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO C 503

Chain	Residue
C	LEU305
C	HOH627
D	LEU305

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO C 504

Chain	Residue
C	LYS254
C	ALA319
D	LYS275
D	TYR300

site_id	AD4
Number of Residues	15
Details	binding site for residue GCP D 501

Chain	Residue
D	VAL18
D	ASP19
D	HIS20
D	GLY21
D	LYS22
D	THR23
D	THR24
D	GLY96
D	ASN149
D	LYS150
D	ASP152
D	SER184
D	ALA185
D	LEU186
D	HOH648

site_id	AD5
Number of Residues	8
Details	binding site for residue EDO D 502

Chain	Residue
D	SER314
D	VAL361
D	SER364
D	VAL386
D	ALA387
D	TRP389
D	HOH616
D	HOH623

site_id	AD6
Number of Residues	19
Details	binding site for residue GCP E 501

Chain	Residue
E	VAL18
E	ASP19
E	HIS20
E	GLY21
E	LYS22
E	THR23
E	THR24
E	MET45
E	THR46
E	GLY96
E	ASN149
E	LYS150
E	ASP152
E	VAL153
E	SER184
E	ALA185
E	LEU186
E	HOH602
E	HOH632

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	35
Details	Region: {"description":"G1","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Region: {"description":"G2","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	15
Details	Region: {"description":"G3","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	15
Details	Region: {"description":"G4","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	10
Details	Region: {"description":"G5","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	50
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RD1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RD1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16407071","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8U082","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)