6H62
QTRT1, the catalytic subunit of murine tRNA-Guanine Transglycosylase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0006400 | biological_process | tRNA modification |
| A | 0008033 | biological_process | tRNA processing |
| A | 0008479 | molecular_function | tRNA-guanosine(34) queuine transglycosylase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046982 | molecular_function | protein heterodimerization activity |
| A | 0101030 | biological_process | tRNA-guanine transglycosylation |
| A | 1990234 | cellular_component | transferase complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005741 | cellular_component | mitochondrial outer membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0006400 | biological_process | tRNA modification |
| B | 0008033 | biological_process | tRNA processing |
| B | 0008479 | molecular_function | tRNA-guanosine(34) queuine transglycosylase activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046982 | molecular_function | protein heterodimerization activity |
| B | 0101030 | biological_process | tRNA-guanine transglycosylation |
| B | 1990234 | cellular_component | transferase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | CYS317 |
| A | CYS319 |
| A | CYS322 |
| A | HIS348 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | GLN355 |
| A | ALA359 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | HIS348 |
| B | CYS317 |
| B | CYS319 |
| B | CYS322 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| B | PRO295 |
| B | GLN355 |
| B | HOH604 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_03218 |
| Chain | Residue | Details |
| A | ASP105 | |
| B | ASP105 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_03218 |
| Chain | Residue | Details |
| A | ASP279 | |
| B | ASP279 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03218 |
| Chain | Residue | Details |
| A | ASP105 | |
| B | ASP105 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03218, ECO:0000269|PubMed:35815944, ECO:0007744|PDB:7OVO, ECO:0007744|PDB:7OWZ |
| Chain | Residue | Details |
| A | ASP159 | |
| A | GLN202 | |
| A | GLY229 | |
| B | ASP159 | |
| B | GLN202 | |
| B | GLY229 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03218, ECO:0000269|PubMed:35815944, ECO:0007744|PDB:6H62, ECO:0007744|PDB:7B2I, ECO:0007744|PDB:7OV9, ECO:0007744|PDB:7OVO, ECO:0007744|PDB:7OVS, ECO:0007744|PDB:7OWZ |
| Chain | Residue | Details |
| A | CYS317 | |
| A | CYS319 | |
| A | CYS322 | |
| A | HIS348 | |
| B | CYS317 | |
| B | CYS319 | |
| B | CYS322 | |
| B | HIS348 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:Q9BXR0 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9BXR0 |
| Chain | Residue | Details |
| A | SER139 | |
| B | SER139 |
