Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue HEC A 601 |
| Chain | Residue |
| A | TYR90 |
| A | CYS120 |
| A | HIS121 |
| A | HIS170 |
| A | ILE178 |
| A | MET180 |
| A | SER392 |
| A | ASP393 |
| A | ARG394 |
| A | HEC602 |
| A | HOH721 |
| A | TYR97 |
| A | HOH768 |
| B | LEU67 |
| B | HEC302 |
| A | MET100 |
| A | ASN102 |
| A | LEU103 |
| A | HIS105 |
| A | PHE108 |
| A | LEU116 |
| A | CYS117 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | binding site for residue HEC A 602 |
| Chain | Residue |
| A | TYR90 |
| A | PRO93 |
| A | HIS121 |
| A | ILE128 |
| A | TRP132 |
| A | HIS137 |
| A | HIS165 |
| A | CYS166 |
| A | CYS169 |
| A | HIS170 |
| A | MET180 |
| A | PRO181 |
| A | LYS245 |
| A | ASP247 |
| A | ARG252 |
| A | HIS253 |
| A | PHE255 |
| A | HIS391 |
| A | SER392 |
| A | PHE395 |
| A | HEC601 |
| A | HEC603 |
| A | HOH751 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue HEC A 603 |
| Chain | Residue |
| A | HIS137 |
| A | LEU146 |
| A | THR150 |
| A | ILE153 |
| A | VAL164 |
| A | VAL185 |
| A | CYS186 |
| A | CYS189 |
| A | HIS190 |
| A | CYS246 |
| A | PHE255 |
| A | ALA257 |
| A | HEC602 |
| A | HEC605 |
| A | HOH707 |
| A | HOH762 |
| A | HOH792 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | binding site for residue HEC A 604 |
| Chain | Residue |
| A | ARG205 |
| A | PRO206 |
| A | ALA214 |
| A | VAL218 |
| A | TRP220 |
| A | GLN233 |
| A | GLY235 |
| A | CYS236 |
| A | CYS239 |
| A | HIS240 |
| A | CYS269 |
| A | HIS270 |
| A | HIS275 |
| A | MET341 |
| A | PHE483 |
| A | LYS510 |
| A | ASP518 |
| A | TRP521 |
| A | HEC606 |
| A | HEC607 |
| A | HOH752 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for residue HEC A 605 |
| Chain | Residue |
| A | HEC606 |
| A | HOH707 |
| A | HOH723 |
| A | TYR145 |
| A | LYS149 |
| A | CYS186 |
| A | HIS190 |
| A | GLN193 |
| A | CYS246 |
| A | CYS249 |
| A | HIS250 |
| A | GLY260 |
| A | ARG261 |
| A | PRO302 |
| A | LEU303 |
| A | GLN318 |
| A | MET322 |
| A | HIS331 |
| A | HEC603 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | binding site for residue HEC A 606 |
| Chain | Residue |
| A | PRO206 |
| A | ASN207 |
| A | HIS208 |
| A | SER211 |
| A | ALA214 |
| A | CYS239 |
| A | HIS240 |
| A | VAL248 |
| A | ALA265 |
| A | CYS266 |
| A | CYS269 |
| A | HIS270 |
| A | PRO333 |
| A | VAL334 |
| A | ARG340 |
| A | MET341 |
| A | HEC604 |
| A | HEC605 |
| A | HEC607 |
| A | HOH714 |
| site_id | AC7 |
| Number of Residues | 21 |
| Details | binding site for residue HEC A 607 |
| Chain | Residue |
| A | HIS270 |
| A | ASP277 |
| A | TYR281 |
| A | HIS286 |
| A | THR316 |
| A | CYS317 |
| A | CYS320 |
| A | HIS321 |
| A | GLY337 |
| A | ILE338 |
| A | TRP339 |
| A | ARG340 |
| A | ARG380 |
| A | TRP383 |
| A | TYR509 |
| A | LYS510 |
| A | HIS514 |
| A | HEC604 |
| A | HEC606 |
| A | HEC608 |
| A | HOH745 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | binding site for residue HEC A 608 |
| Chain | Residue |
| A | TRP91 |
| A | ASP131 |
| A | LYS245 |
| A | ASP247 |
| A | THR251 |
| A | ARG252 |
| A | LYS285 |
| A | HIS286 |
| A | ARG313 |
| A | THR314 |
| A | PRO315 |
| A | VAL386 |
| A | CYS387 |
| A | CYS390 |
| A | HIS391 |
| A | TYR399 |
| A | HEC607 |
| A | HOH736 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | binding site for residue HEC B 301 |
| Chain | Residue |
| B | LYS84 |
| B | CYS172 |
| B | CYS175 |
| B | HIS176 |
| B | ILE198 |
| B | PHE201 |
| B | PHE208 |
| B | LYS209 |
| B | GLY210 |
| B | ARG220 |
| B | PHE221 |
| B | PRO229 |
| B | MET230 |
| B | PHE233 |
| B | LEU245 |
| site_id | AD1 |
| Number of Residues | 20 |
| Details | binding site for residue HEC B 302 |
| Chain | Residue |
| A | HEC601 |
| B | TYR52 |
| B | CYS53 |
| B | CYS56 |
| B | HIS57 |
| B | PRO73 |
| B | LYS74 |
| B | PRO75 |
| B | ARG76 |
| B | PHE78 |
| B | TYR83 |
| B | LYS84 |
| B | PHE85 |
| B | ILE103 |
| B | SER110 |
| B | THR111 |
| B | MET112 |
| B | TRP115 |
| B | LEU130 |
| B | LYS209 |
