6H2S
Sulfolobus solfataricus 2-keto-3-deoxygluconate aldolase T157V/D181Q/A198L variant, pyruvate complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008674 | molecular_function | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity |
| A | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| A | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| A | 0016829 | molecular_function | lyase activity |
| B | 0008674 | molecular_function | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity |
| B | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| B | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| B | 0016829 | molecular_function | lyase activity |
| C | 0008674 | molecular_function | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity |
| C | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| C | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| C | 0016829 | molecular_function | lyase activity |
| D | 0008674 | molecular_function | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity |
| D | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| D | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| D | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue PYR A 301 |
| Chain | Residue |
| A | PRO7 |
| A | THR43 |
| A | THR44 |
| A | TYR130 |
| A | VAL157 |
| A | LEU198 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | SER243 |
| B | ARG106 |
| B | MET107 |
| B | SER108 |
| B | HIS111 |
| B | HOH440 |
| A | GLY240 |
| A | SER241 |
| A | LEU242 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | ASN67 |
| A | LYS68 |
| A | ASP92 |
| A | ILE93 |
| A | VAL94 |
| A | HOH545 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue PEG A 304 |
| Chain | Residue |
| A | TYR103 |
| A | TYR104 |
| A | THR134 |
| A | THR136 |
| A | GLY137 |
| A | LYS138 |
| A | HOH439 |
| B | THR134 |
| B | ALA135 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue IPA A 305 |
| Chain | Residue |
| A | CYS120 |
| A | SER123 |
| A | HIS125 |
| A | HOH433 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue PYR B 301 |
| Chain | Residue |
| B | PRO7 |
| B | THR43 |
| B | THR44 |
| B | TYR130 |
| B | VAL196 |
| B | LEU198 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 302 |
| Chain | Residue |
| A | SER108 |
| A | HIS111 |
| B | GLY240 |
| B | SER241 |
| B | LEU242 |
| B | SER243 |
| B | HOH455 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 303 |
| Chain | Residue |
| B | LEU112 |
| B | LYS138 |
| B | ASP139 |
| B | HOH405 |
| B | HOH427 |
| B | HOH514 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue PYR C 301 |
| Chain | Residue |
| C | PRO7 |
| C | THR43 |
| C | THR44 |
| C | TYR130 |
| C | VAL157 |
| C | VAL196 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 302 |
| Chain | Residue |
| C | GLY240 |
| C | SER241 |
| C | LEU242 |
| C | SER243 |
| D | MET107 |
| D | SER108 |
| D | HIS111 |
| D | HOH461 |
| site_id | AD2 |
| Number of Residues | 10 |
| Details | binding site for residue PEG C 303 |
| Chain | Residue |
| C | TYR103 |
| C | TYR104 |
| C | PRO133 |
| C | THR134 |
| C | THR136 |
| C | GLY137 |
| C | LYS138 |
| C | HOH435 |
| D | THR134 |
| D | ALA135 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue PYR D 301 |
| Chain | Residue |
| D | PRO7 |
| D | THR43 |
| D | THR44 |
| D | TYR130 |
| D | VAL157 |
| D | VAL196 |
| D | LEU198 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 302 |
| Chain | Residue |
| C | ARG106 |
| C | SER108 |
| C | HIS111 |
| D | GLY240 |
| D | SER241 |
| D | LEU242 |
| D | SER243 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 303 |
| Chain | Residue |
| D | TYR63 |
| D | VAL65 |
| D | ASN67 |
| D | HOH403 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Schiff-base intermediate with substrate","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Proton shuttle","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
