6H27
Structure of S70C BlaC from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008800 | molecular_function | beta-lactamase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017001 | biological_process | antibiotic catabolic process |
| A | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| A | 0033250 | molecular_function | penicillinase activity |
| A | 0033251 | molecular_function | cephalosporinase activity |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046677 | biological_process | response to antibiotic |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008800 | molecular_function | beta-lactamase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0017001 | biological_process | antibiotic catabolic process |
| B | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| B | 0033250 | molecular_function | penicillinase activity |
| B | 0033251 | molecular_function | cephalosporinase activity |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 401 |
| Chain | Residue |
| A | CYS70 |
| A | SER128 |
| A | THR237 |
| A | GLY238 |
| A | THR239 |
| A | HOH504 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue PG0 A 402 |
| Chain | Residue |
| A | LYS205 |
| A | ARG224 |
| A | ALA229 |
| A | HOH525 |
| A | HOH546 |
| A | GLN83 |
| A | ASN84 |
| A | PRO85 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue PG0 B 401 |
| Chain | Residue |
| B | ARG33 |
| B | GLU36 |
| B | LEU37 |
| B | GLY152 |
| B | ARG155 |
| B | SER156 |
| B | GLU283 |
| B | THR286 |
| B | CYS287 |
| B | HOH579 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Acyl-ester intermediate => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112 |
| Chain | Residue | Details |
| A | CYS70 | |
| B | CYS70 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000303|PubMed:20353175, ECO:0000303|PubMed:20961112 |
| Chain | Residue | Details |
| A | GLU168 | |
| B | GLU168 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112 |
| Chain | Residue | Details |
| A | SER128 | |
| A | THR237 | |
| B | SER128 | |
| B | THR237 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Increases nucleophilicity of active site Ser => ECO:0000303|PubMed:20353175, ECO:0000303|PubMed:20961112 |
| Chain | Residue | Details |
| A | LYS73 | |
| B | LYS73 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Functions as a gatekeeper residue that regulates substrate accessibility to the enzyme active site => ECO:0000303|PubMed:24023821 |
| Chain | Residue | Details |
| A | ILE103 | |
| B | ILE103 |
