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6H25

Human nuclear RNA exosome EXO-10-MPP6 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000175molecular_function3'-5'-RNA exonuclease activity
A0000176cellular_componentnuclear exosome (RNase complex)
A0000177cellular_componentcytoplasmic exosome (RNase complex)
A0000178cellular_componentexosome (RNase complex)
A0000228cellular_componentnuclear chromosome
A0000288biological_processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
A0000467biological_processexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A0000956biological_processnuclear-transcribed mRNA catabolic process
A0003723molecular_functionRNA binding
A0004532molecular_functionRNA exonuclease activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006364biological_processrRNA processing
A0006396biological_processRNA processing
A0006401biological_processRNA catabolic process
A0006402biological_processmRNA catabolic process
A0006955biological_processimmune response
A0030307biological_processpositive regulation of cell growth
A0034473biological_processU1 snRNA 3'-end processing
A0034475biological_processU4 snRNA 3'-end processing
A0034476biological_processU5 snRNA 3'-end processing
A0035925molecular_functionmRNA 3'-UTR AU-rich region binding
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070062cellular_componentextracellular exosome
A0071028biological_processnuclear mRNA surveillance
A0071035biological_processnuclear polyadenylation-dependent rRNA catabolic process
A0071038biological_processTRAMP-dependent tRNA surveillance pathway
A0101019cellular_componentnucleolar exosome (RNase complex)
A1902494cellular_componentcatalytic complex
B0000175molecular_function3'-5'-RNA exonuclease activity
B0000176cellular_componentnuclear exosome (RNase complex)
B0000177cellular_componentcytoplasmic exosome (RNase complex)
B0000178cellular_componentexosome (RNase complex)
B0000460biological_processmaturation of 5.8S rRNA
B0000791cellular_componenteuchromatin
B0000956biological_processnuclear-transcribed mRNA catabolic process
B0003723molecular_functionRNA binding
B0004532molecular_functionRNA exonuclease activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006364biological_processrRNA processing
B0006396biological_processRNA processing
B0006401biological_processRNA catabolic process
B0016075biological_processrRNA catabolic process
B0030307biological_processpositive regulation of cell growth
B0034475biological_processU4 snRNA 3'-end processing
B0035925molecular_functionmRNA 3'-UTR AU-rich region binding
B0043231cellular_componentintracellular membrane-bounded organelle
B0045006biological_processDNA deamination
B0051607biological_processdefense response to virus
B0071028biological_processnuclear mRNA surveillance
B0071044biological_processhistone mRNA catabolic process
B0071051biological_processpoly(A)-dependent snoRNA 3'-end processing
B0101019cellular_componentnucleolar exosome (RNase complex)
B1902494cellular_componentcatalytic complex
C0000176cellular_componentnuclear exosome (RNase complex)
C0000177cellular_componentcytoplasmic exosome (RNase complex)
C0000178cellular_componentexosome (RNase complex)
C0000288biological_processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
C0000467biological_processexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C0000956biological_processnuclear-transcribed mRNA catabolic process
C0001650cellular_componentfibrillar center
C0003723molecular_functionRNA binding
C0004532molecular_functionRNA exonuclease activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006364biological_processrRNA processing
C0006396biological_processRNA processing
C0006401biological_processRNA catabolic process
C0034473biological_processU1 snRNA 3'-end processing
C0034475biological_processU4 snRNA 3'-end processing
C0034476biological_processU5 snRNA 3'-end processing
C0035925molecular_functionmRNA 3'-UTR AU-rich region binding
C0042802molecular_functionidentical protein binding
C0043231cellular_componentintracellular membrane-bounded organelle
C0071028biological_processnuclear mRNA surveillance
C0071035biological_processnuclear polyadenylation-dependent rRNA catabolic process
C0071038biological_processTRAMP-dependent tRNA surveillance pathway
C0101019cellular_componentnucleolar exosome (RNase complex)
C1902494cellular_componentcatalytic complex
D0000175molecular_function3'-5'-RNA exonuclease activity
D0000176cellular_componentnuclear exosome (RNase complex)
D0000177cellular_componentcytoplasmic exosome (RNase complex)
D0000178cellular_componentexosome (RNase complex)
D0000791cellular_componenteuchromatin
D0000956biological_processnuclear-transcribed mRNA catabolic process
D0003677molecular_functionDNA binding
D0003723molecular_functionRNA binding
D0004532molecular_functionRNA exonuclease activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006364biological_processrRNA processing
D0006396biological_processRNA processing
D0006401biological_processRNA catabolic process
D0006402biological_processmRNA catabolic process
D0016075biological_processrRNA catabolic process
D0034475biological_processU4 snRNA 3'-end processing
D0045006biological_processDNA deamination
D0051607biological_processdefense response to virus
D0071028biological_processnuclear mRNA surveillance
D0071051biological_processpoly(A)-dependent snoRNA 3'-end processing
D0101019cellular_componentnucleolar exosome (RNase complex)
D1902494cellular_componentcatalytic complex
E0000175molecular_function3'-5'-RNA exonuclease activity
E0000176cellular_componentnuclear exosome (RNase complex)
E0000177cellular_componentcytoplasmic exosome (RNase complex)
E0000178cellular_componentexosome (RNase complex)
E0000288biological_processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
E0000467biological_processexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E0000956biological_processnuclear-transcribed mRNA catabolic process
E0003723molecular_functionRNA binding
E0004532molecular_functionRNA exonuclease activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005730cellular_componentnucleolus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006364biological_processrRNA processing
E0006396biological_processRNA processing
E0006401biological_processRNA catabolic process
E0034473biological_processU1 snRNA 3'-end processing
E0034475biological_processU4 snRNA 3'-end processing
E0034476biological_processU5 snRNA 3'-end processing
E0035925molecular_functionmRNA 3'-UTR AU-rich region binding
E0071028biological_processnuclear mRNA surveillance
E0071035biological_processnuclear polyadenylation-dependent rRNA catabolic process
E0071038biological_processTRAMP-dependent tRNA surveillance pathway
E0101019cellular_componentnucleolar exosome (RNase complex)
E1902494cellular_componentcatalytic complex
F0000176cellular_componentnuclear exosome (RNase complex)
F0000177cellular_componentcytoplasmic exosome (RNase complex)
F0000178cellular_componentexosome (RNase complex)
F0000956biological_processnuclear-transcribed mRNA catabolic process
F0003723molecular_functionRNA binding
F0004532molecular_functionRNA exonuclease activity
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006364biological_processrRNA processing
F0006396biological_processRNA processing
F0006401biological_processRNA catabolic process
F0016075biological_processrRNA catabolic process
F0034475biological_processU4 snRNA 3'-end processing
F0045006biological_processDNA deamination
F0045190biological_processisotype switching
F0045830biological_processpositive regulation of isotype switching
F0071028biological_processnuclear mRNA surveillance
F0071051biological_processpoly(A)-dependent snoRNA 3'-end processing
F0101019cellular_componentnucleolar exosome (RNase complex)
F1902494cellular_componentcatalytic complex
G0000175molecular_function3'-5'-RNA exonuclease activity
G0000176cellular_componentnuclear exosome (RNase complex)
G0000177cellular_componentcytoplasmic exosome (RNase complex)
G0000178cellular_componentexosome (RNase complex)
G0000288biological_processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
G0000467biological_processexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G0000791cellular_componenteuchromatin
G0000956biological_processnuclear-transcribed mRNA catabolic process
G0003723molecular_functionRNA binding
G0004532molecular_functionRNA exonuclease activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005730cellular_componentnucleolus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006364biological_processrRNA processing
G0006396biological_processRNA processing
G0006401biological_processRNA catabolic process
G0006402biological_processmRNA catabolic process
G0034475biological_processU4 snRNA 3'-end processing
G0045006biological_processDNA deamination
G0045190biological_processisotype switching
G0045830biological_processpositive regulation of isotype switching
G0071034biological_processCUT catabolic process
G0071035biological_processnuclear polyadenylation-dependent rRNA catabolic process
G0071038biological_processTRAMP-dependent tRNA surveillance pathway
G0071051biological_processpoly(A)-dependent snoRNA 3'-end processing
G0101019cellular_componentnucleolar exosome (RNase complex)
H0000175molecular_function3'-5'-RNA exonuclease activity
H0000176cellular_componentnuclear exosome (RNase complex)
H0000177cellular_componentcytoplasmic exosome (RNase complex)
H0000178cellular_componentexosome (RNase complex)
H0000288biological_processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
H0000467biological_processexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0000956biological_processnuclear-transcribed mRNA catabolic process
H0003723molecular_functionRNA binding
H0004532molecular_functionRNA exonuclease activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005730cellular_componentnucleolus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006364biological_processrRNA processing
H0006396biological_processRNA processing
H0006401biological_processRNA catabolic process
H0008312molecular_function7S RNA binding
H0030307biological_processpositive regulation of cell growth
H0034475biological_processU4 snRNA 3'-end processing
H0071034biological_processCUT catabolic process
H0071035biological_processnuclear polyadenylation-dependent rRNA catabolic process
H0071038biological_processTRAMP-dependent tRNA surveillance pathway
H0071051biological_processpoly(A)-dependent snoRNA 3'-end processing
H0101019cellular_componentnucleolar exosome (RNase complex)
I0000176cellular_componentnuclear exosome (RNase complex)
I0000177cellular_componentcytoplasmic exosome (RNase complex)
I0000178cellular_componentexosome (RNase complex)
I0003676molecular_functionnucleic acid binding
I0003723molecular_functionRNA binding
I0004532molecular_functionRNA exonuclease activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005730cellular_componentnucleolus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006364biological_processrRNA processing
I0006396biological_processRNA processing
I0006401biological_processRNA catabolic process
I0101019cellular_componentnucleolar exosome (RNase complex)
J0000175molecular_function3'-5'-RNA exonuclease activity
J0000176cellular_componentnuclear exosome (RNase complex)
J0000177cellular_componentcytoplasmic exosome (RNase complex)
J0000178cellular_componentexosome (RNase complex)
J0000288biological_processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
J0003723molecular_functionRNA binding
J0004519molecular_functionendonuclease activity
J0004527molecular_functionexonuclease activity
J0004540molecular_functionRNA nuclease activity
J0005085molecular_functionguanyl-nucleotide exchange factor activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005730cellular_componentnucleolus
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006364biological_processrRNA processing
J0006396biological_processRNA processing
J0006401biological_processRNA catabolic process
J0016020cellular_componentmembrane
J0016075biological_processrRNA catabolic process
J0071031biological_processnuclear mRNA surveillance of mRNA 3'-end processing
J0071034biological_processCUT catabolic process
K0000176cellular_componentnuclear exosome (RNase complex)
K0000178cellular_componentexosome (RNase complex)
K0000460biological_processmaturation of 5.8S rRNA
K0003723molecular_functionRNA binding
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005730cellular_componentnucleolus
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0006364biological_processrRNA processing
Functional Information from PROSITE/UniProt
site_idPS01175
Number of Residues25
DetailsRIBONUCLEASE_II Ribonuclease II family signature. HYGLaspi.YThFTSPIRRYaDvivH
ChainResidueDetails
JHIS764-HIS788

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
KSER110

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
KTHR147

site_idSWS_FT_FI3
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
KLYS37
KLYS86
KLYS127
KLYS150

site_idSWS_FT_FI4
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364
ChainResidueDetails
ASER346
KLYS153

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER392
ASER394

site_idSWS_FT_FI6
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS297

site_idSWS_FT_FI7
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS419

226707

PDB entries from 2024-10-30

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