6H0X
Crystal Structure of KDM4D with tetrazolylhydrazide ligand AA040
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS238 |
| A | HIS244 |
| A | CYS310 |
| A | CYS312 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 402 |
| Chain | Residue |
| A | ASN128 |
| A | LYS186 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | LYS124 |
| A | ASN128 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | THR252 |
| A | ARG263 |
| A | PRO251 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | TYR181 |
| A | GLU194 |
| A | ALA292 |
| A | ASN294 |
| A | THR318 |
| A | FJB407 |
| A | HOH649 |
| A | HOH735 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue NI A 406 |
| Chain | Residue |
| A | HIS192 |
| A | GLU194 |
| A | HIS280 |
| A | FJB407 |
| A | HOH640 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | binding site for residue FJB A 407 |
| Chain | Residue |
| A | HIS90 |
| A | TYR136 |
| A | TYR181 |
| A | HIS192 |
| A | GLU194 |
| A | ASN202 |
| A | LYS210 |
| A | LYS245 |
| A | HIS280 |
| A | ARG316 |
| A | EDO405 |
| A | NI406 |
| A | HOH620 |
| A | HOH640 |
| A | HOH649 |
| A | HOH680 |
| A | HOH687 |
| A | HOH735 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:B2RXH2 |
| Chain | Residue | Details |
| A | TYR136 | |
| A | ASN202 | |
| A | LYS210 | |
| A | LYS245 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26741168 |
| Chain | Residue | Details |
| A | HIS192 | |
| A | GLU194 | |
| A | HIS280 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C |
| Chain | Residue | Details |
| A | CYS238 | |
| A | HIS244 | |
| A | CYS310 | |
| A | CYS312 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: PolyADP-ribosyl glutamic acid => ECO:0000269|PubMed:23102699 |
| Chain | Residue | Details |
| A | GLU26 | |
| A | GLU27 |
