6H05

Cryo-electron microscopic structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate (2-oxoglutarate) dehydrogenase complex [residues 218-453]

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
A	0006099	biological_process	tricarboxylic acid cycle
A	0016746	molecular_function	acyltransferase activity
A	0045252	cellular_component	oxoglutarate dehydrogenase complex

Functional Information from PROSITE/UniProt

site_id	PS00189
Number of Residues	30
Details	LIPOYL 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. GdtVaedEVVceIETdKTSvqVpspanGvI

Chain	Residue	Details
A	GLY27-ILE56

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:30929736

Chain	Residue	Details
A	HIS357

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:Q9N0F1

Chain	Residue	Details
A	ASP361

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9D2G2

Chain	Residue	Details
A	SER14

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-lipoyllysine => ECO:0000255|PROSITE-ProRule:PRU01066

Chain	Residue	Details
A	LYS43

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site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9D2G2

Chain	Residue	Details
A	LYS87
A	LYS200
A	LYS205
A	LYS206
A	LYS210
A	LYS240

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