6GYN
Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005249 | molecular_function | voltage-gated potassium channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005249 | molecular_function | voltage-gated potassium channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005249 | molecular_function | voltage-gated potassium channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005249 | molecular_function | voltage-gated potassium channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrEGTiGKkMYFIqhG |
| Chain | Residue | Details |
| A | ILE622-GLY638 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 88 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2018","submissionDatabase":"PDB data bank","title":"Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel.","authors":["Shintre C.A.","Pike A.C.W.","Tessitore A.","Young M.","Bushell S.R.","Strain-Damerell C.","Mukhopadhyay S.","Burgess-Brown N.A.","Huiskonen J.T.","Arrowsmith C.H.","Edwards A.M.","Bountra C.","Carpenter E.P."]}},{"source":"PDB","id":"6GYN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 220 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2018","submissionDatabase":"PDB data bank","title":"Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel.","authors":["Shintre C.A.","Pike A.C.W.","Tessitore A.","Young M.","Bushell S.R.","Strain-Damerell C.","Mukhopadhyay S.","Burgess-Brown N.A.","Huiskonen J.T.","Arrowsmith C.H.","Edwards A.M.","Bountra C.","Carpenter E.P."]}},{"source":"PDB","id":"6GYN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 136 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 88 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2018","submissionDatabase":"PDB data bank","title":"Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel.","authors":["Shintre C.A.","Pike A.C.W.","Tessitore A.","Young M.","Bushell S.R.","Strain-Damerell C.","Mukhopadhyay S.","Burgess-Brown N.A.","Huiskonen J.T.","Arrowsmith C.H.","Edwards A.M.","Bountra C.","Carpenter E.P."]}},{"source":"PDB","id":"6GYN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2018","submissionDatabase":"PDB data bank","title":"Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel.","authors":["Shintre C.A.","Pike A.C.W.","Tessitore A.","Young M.","Bushell S.R.","Strain-Damerell C.","Mukhopadhyay S.","Burgess-Brown N.A.","Huiskonen J.T.","Arrowsmith C.H.","Edwards A.M.","Bountra C.","Carpenter E.P."]}},{"source":"PDB","id":"6GYN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 88 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2018","submissionDatabase":"PDB data bank","title":"Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel.","authors":["Shintre C.A.","Pike A.C.W.","Tessitore A.","Young M.","Bushell S.R.","Strain-Damerell C.","Mukhopadhyay S.","Burgess-Brown N.A.","Huiskonen J.T.","Arrowsmith C.H.","Edwards A.M.","Bountra C.","Carpenter E.P."]}},{"source":"PDB","id":"6GYN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 84 |
| Details | Intramembrane: {"description":"Pore-forming; Name=Segment H5","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 100 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2018","submissionDatabase":"PDB data bank","title":"Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel.","authors":["Shintre C.A.","Pike A.C.W.","Tessitore A.","Young M.","Bushell S.R.","Strain-Damerell C.","Mukhopadhyay S.","Burgess-Brown N.A.","Huiskonen J.T.","Arrowsmith C.H.","Edwards A.M.","Bountra C.","Carpenter E.P."]}},{"source":"PDB","id":"6GYN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24776929","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KL1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22006928","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23103389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3U11","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HBN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9TV66","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22006928","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3U11","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
