6GVS
Engineered glycolyl-CoA reductase comprising 8 mutations with bound NADP+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| I | 0000166 | molecular_function | nucleotide binding |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
| I | 0016491 | molecular_function | oxidoreductase activity |
| I | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| J | 0000166 | molecular_function | nucleotide binding |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
| J | 0016491 | molecular_function | oxidoreductase activity |
| J | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue NAP A 601 |
| Chain | Residue |
| A | PRO194 |
| A | GLY295 |
| A | ALA296 |
| A | CYS328 |
| A | GLU417 |
| A | HIS447 |
| A | PHE491 |
| A | THR492 |
| A | ILE493 |
| A | HOH703 |
| A | HOH743 |
| A | THR195 |
| A | HIS221 |
| A | ARG257 |
| A | THR275 |
| A | GLY276 |
| A | GLY277 |
| A | LEU280 |
| A | ALA294 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue K A 602 |
| Chain | Residue |
| A | ASN298 |
| A | LYS332 |
| A | GLU333 |
| A | PHE413 |
| A | VAL414 |
| A | GLU416 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue NAP B 601 |
| Chain | Residue |
| B | THR195 |
| B | THR196 |
| B | HIS221 |
| B | GLY222 |
| B | ARG223 |
| B | THR275 |
| B | GLY276 |
| B | GLY277 |
| B | ALA294 |
| B | GLY295 |
| B | ALA296 |
| B | CYS328 |
| B | THR378 |
| B | GLU417 |
| B | HIS447 |
| B | PHE491 |
| B | THR492 |
| B | ILE493 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue K B 602 |
| Chain | Residue |
| B | ASN298 |
| B | LYS332 |
| B | GLU333 |
| B | PHE413 |
| B | VAL414 |
| B | GLU416 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for residue NAP C 601 |
| Chain | Residue |
| C | PRO194 |
| C | THR195 |
| C | THR196 |
| C | HIS221 |
| C | GLY222 |
| C | ARG223 |
| C | THR275 |
| C | GLY276 |
| C | GLY277 |
| C | ALA294 |
| C | GLY295 |
| C | ALA296 |
| C | CYS328 |
| C | THR378 |
| C | GLU417 |
| C | HIS447 |
| C | PHE491 |
| C | THR492 |
| C | ILE493 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue K C 602 |
| Chain | Residue |
| C | ASN298 |
| C | LYS332 |
| C | GLU333 |
| C | PHE413 |
| C | VAL414 |
| C | GLU416 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | binding site for residue NAP D 601 |
| Chain | Residue |
| D | PRO194 |
| D | THR195 |
| D | THR196 |
| D | HIS221 |
| D | GLY222 |
| D | ARG223 |
| D | THR275 |
| D | GLY276 |
| D | ALA294 |
| D | GLY295 |
| D | ALA296 |
| D | CYS328 |
| D | GLU417 |
| D | HIS447 |
| D | PHE491 |
| D | THR492 |
| D | ILE493 |
| D | HOH710 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue K D 602 |
| Chain | Residue |
| D | ASN298 |
| D | LYS332 |
| D | GLU333 |
| D | PHE413 |
| D | VAL414 |
| D | GLU416 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | binding site for residue NAP E 601 |
| Chain | Residue |
| E | THR195 |
| E | HIS221 |
| E | GLY222 |
| E | ARG257 |
| E | THR275 |
| E | GLY276 |
| E | GLY277 |
| E | ALA294 |
| E | GLY295 |
| E | ALA296 |
| E | CYS328 |
| E | GLU417 |
| E | HIS447 |
| E | PHE491 |
| E | THR492 |
| E | ILE493 |
| E | PRO194 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue K E 602 |
| Chain | Residue |
| E | ASN298 |
| E | LYS332 |
| E | GLU333 |
| E | PHE413 |
| E | VAL414 |
| E | GLU416 |
| site_id | AD2 |
| Number of Residues | 18 |
| Details | binding site for residue NAP F 601 |
| Chain | Residue |
| F | PRO194 |
| F | THR195 |
| F | THR196 |
| F | HIS221 |
| F | GLY222 |
| F | ARG223 |
| F | THR275 |
| F | GLY276 |
| F | ALA294 |
| F | GLY295 |
| F | ALA296 |
| F | CYS328 |
| F | GLU417 |
| F | HIS447 |
| F | PHE491 |
| F | THR492 |
| F | ILE493 |
| F | HOH702 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue K F 602 |
| Chain | Residue |
| F | ASN298 |
| F | LYS332 |
| F | GLU333 |
| F | PHE413 |
| F | VAL414 |
| F | GLU416 |
| site_id | AD4 |
| Number of Residues | 19 |
| Details | binding site for residue NAP G 601 |
| Chain | Residue |
| G | ILE192 |
| G | PRO194 |
| G | THR195 |
| G | HIS221 |
| G | GLY222 |
| G | ARG257 |
| G | THR260 |
| G | THR275 |
| G | GLY276 |
| G | GLY277 |
| G | LEU280 |
| G | ALA294 |
| G | GLY295 |
| G | ALA296 |
| G | CYS328 |
| G | GLU417 |
| G | HIS447 |
| G | PHE491 |
| G | ILE493 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue K G 602 |
| Chain | Residue |
| G | ASN298 |
| G | LYS332 |
| G | GLU333 |
| G | PHE413 |
| G | VAL414 |
| G | GLU416 |
| site_id | AD6 |
| Number of Residues | 17 |
| Details | binding site for residue NAP H 601 |
| Chain | Residue |
| H | PRO194 |
| H | THR195 |
| H | THR196 |
| H | HIS221 |
| H | GLY222 |
| H | ARG223 |
| H | THR275 |
| H | GLY276 |
| H | ALA294 |
| H | GLY295 |
| H | ALA296 |
| H | CYS328 |
| H | GLU417 |
| H | HIS447 |
| H | PHE491 |
| H | THR492 |
| H | ILE493 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue K H 602 |
| Chain | Residue |
| H | ASN298 |
| H | LYS332 |
| H | GLU333 |
| H | PHE413 |
| H | VAL414 |
| H | GLU416 |
| site_id | AD8 |
| Number of Residues | 18 |
| Details | binding site for residue NAP I 601 |
| Chain | Residue |
| I | PRO194 |
| I | THR195 |
| I | HIS221 |
| I | ARG257 |
| I | THR275 |
| I | GLY276 |
| I | GLY277 |
| I | LEU280 |
| I | ALA294 |
| I | GLY295 |
| I | ALA296 |
| I | CYS328 |
| I | GLU417 |
| I | HIS447 |
| I | THR492 |
| I | ILE493 |
| I | HOH716 |
| I | HOH730 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue K I 602 |
| Chain | Residue |
| I | ASN298 |
| I | LYS332 |
| I | GLU333 |
| I | PHE413 |
| I | VAL414 |
| I | GLU416 |
| site_id | AE1 |
| Number of Residues | 18 |
| Details | binding site for residue NAP J 601 |
| Chain | Residue |
| J | PRO194 |
| J | THR195 |
| J | THR196 |
| J | HIS221 |
| J | GLY222 |
| J | ARG223 |
| J | THR275 |
| J | GLY276 |
| J | ALA294 |
| J | GLY295 |
| J | ALA296 |
| J | CYS328 |
| J | THR378 |
| J | GLU417 |
| J | HIS447 |
| J | PHE491 |
| J | THR492 |
| J | ILE493 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue K J 602 |
| Chain | Residue |
| J | ASN298 |
| J | LYS332 |
| J | GLU333 |
| J | PHE413 |
| J | VAL414 |
| J | GLU416 |
