6GVS
Engineered glycolyl-CoA reductase comprising 8 mutations with bound NADP+
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
B | 0000166 | molecular_function | nucleotide binding |
B | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
C | 0000166 | molecular_function | nucleotide binding |
C | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
D | 0000166 | molecular_function | nucleotide binding |
D | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
E | 0000166 | molecular_function | nucleotide binding |
E | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
F | 0000166 | molecular_function | nucleotide binding |
F | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
F | 0016491 | molecular_function | oxidoreductase activity |
F | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
G | 0000166 | molecular_function | nucleotide binding |
G | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
G | 0016491 | molecular_function | oxidoreductase activity |
G | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
H | 0000166 | molecular_function | nucleotide binding |
H | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
H | 0016491 | molecular_function | oxidoreductase activity |
H | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
I | 0000166 | molecular_function | nucleotide binding |
I | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
I | 0016491 | molecular_function | oxidoreductase activity |
I | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
J | 0000166 | molecular_function | nucleotide binding |
J | 0008774 | molecular_function | acetaldehyde dehydrogenase (acetylating) activity |
J | 0016491 | molecular_function | oxidoreductase activity |
J | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 19 |
Details | binding site for residue NAP A 601 |
Chain | Residue |
A | PRO194 |
A | GLY295 |
A | ALA296 |
A | CYS328 |
A | GLU417 |
A | HIS447 |
A | PHE491 |
A | THR492 |
A | ILE493 |
A | HOH703 |
A | HOH743 |
A | THR195 |
A | HIS221 |
A | ARG257 |
A | THR275 |
A | GLY276 |
A | GLY277 |
A | LEU280 |
A | ALA294 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue K A 602 |
Chain | Residue |
A | ASN298 |
A | LYS332 |
A | GLU333 |
A | PHE413 |
A | VAL414 |
A | GLU416 |
site_id | AC3 |
Number of Residues | 18 |
Details | binding site for residue NAP B 601 |
Chain | Residue |
B | THR195 |
B | THR196 |
B | HIS221 |
B | GLY222 |
B | ARG223 |
B | THR275 |
B | GLY276 |
B | GLY277 |
B | ALA294 |
B | GLY295 |
B | ALA296 |
B | CYS328 |
B | THR378 |
B | GLU417 |
B | HIS447 |
B | PHE491 |
B | THR492 |
B | ILE493 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue K B 602 |
Chain | Residue |
B | ASN298 |
B | LYS332 |
B | GLU333 |
B | PHE413 |
B | VAL414 |
B | GLU416 |
site_id | AC5 |
Number of Residues | 19 |
Details | binding site for residue NAP C 601 |
Chain | Residue |
C | PRO194 |
C | THR195 |
C | THR196 |
C | HIS221 |
C | GLY222 |
C | ARG223 |
C | THR275 |
C | GLY276 |
C | GLY277 |
C | ALA294 |
C | GLY295 |
C | ALA296 |
C | CYS328 |
C | THR378 |
C | GLU417 |
C | HIS447 |
C | PHE491 |
C | THR492 |
C | ILE493 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue K C 602 |
Chain | Residue |
C | ASN298 |
C | LYS332 |
C | GLU333 |
C | PHE413 |
C | VAL414 |
C | GLU416 |
site_id | AC7 |
Number of Residues | 18 |
Details | binding site for residue NAP D 601 |
Chain | Residue |
D | PRO194 |
D | THR195 |
D | THR196 |
D | HIS221 |
D | GLY222 |
D | ARG223 |
D | THR275 |
D | GLY276 |
D | ALA294 |
D | GLY295 |
D | ALA296 |
D | CYS328 |
D | GLU417 |
D | HIS447 |
D | PHE491 |
D | THR492 |
D | ILE493 |
D | HOH710 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue K D 602 |
Chain | Residue |
D | ASN298 |
D | LYS332 |
D | GLU333 |
D | PHE413 |
D | VAL414 |
D | GLU416 |
site_id | AC9 |
Number of Residues | 17 |
Details | binding site for residue NAP E 601 |
Chain | Residue |
E | THR195 |
E | HIS221 |
E | GLY222 |
E | ARG257 |
E | THR275 |
E | GLY276 |
E | GLY277 |
E | ALA294 |
E | GLY295 |
E | ALA296 |
E | CYS328 |
E | GLU417 |
E | HIS447 |
E | PHE491 |
E | THR492 |
E | ILE493 |
E | PRO194 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue K E 602 |
Chain | Residue |
E | ASN298 |
E | LYS332 |
E | GLU333 |
E | PHE413 |
E | VAL414 |
E | GLU416 |
site_id | AD2 |
Number of Residues | 18 |
Details | binding site for residue NAP F 601 |
Chain | Residue |
F | PRO194 |
F | THR195 |
F | THR196 |
F | HIS221 |
F | GLY222 |
F | ARG223 |
F | THR275 |
F | GLY276 |
F | ALA294 |
F | GLY295 |
F | ALA296 |
F | CYS328 |
F | GLU417 |
F | HIS447 |
F | PHE491 |
F | THR492 |
F | ILE493 |
F | HOH702 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue K F 602 |
Chain | Residue |
F | ASN298 |
F | LYS332 |
F | GLU333 |
F | PHE413 |
F | VAL414 |
F | GLU416 |
site_id | AD4 |
Number of Residues | 19 |
Details | binding site for residue NAP G 601 |
Chain | Residue |
G | ILE192 |
G | PRO194 |
G | THR195 |
G | HIS221 |
G | GLY222 |
G | ARG257 |
G | THR260 |
G | THR275 |
G | GLY276 |
G | GLY277 |
G | LEU280 |
G | ALA294 |
G | GLY295 |
G | ALA296 |
G | CYS328 |
G | GLU417 |
G | HIS447 |
G | PHE491 |
G | ILE493 |
site_id | AD5 |
Number of Residues | 6 |
Details | binding site for residue K G 602 |
Chain | Residue |
G | ASN298 |
G | LYS332 |
G | GLU333 |
G | PHE413 |
G | VAL414 |
G | GLU416 |
site_id | AD6 |
Number of Residues | 17 |
Details | binding site for residue NAP H 601 |
Chain | Residue |
H | PRO194 |
H | THR195 |
H | THR196 |
H | HIS221 |
H | GLY222 |
H | ARG223 |
H | THR275 |
H | GLY276 |
H | ALA294 |
H | GLY295 |
H | ALA296 |
H | CYS328 |
H | GLU417 |
H | HIS447 |
H | PHE491 |
H | THR492 |
H | ILE493 |
site_id | AD7 |
Number of Residues | 6 |
Details | binding site for residue K H 602 |
Chain | Residue |
H | ASN298 |
H | LYS332 |
H | GLU333 |
H | PHE413 |
H | VAL414 |
H | GLU416 |
site_id | AD8 |
Number of Residues | 18 |
Details | binding site for residue NAP I 601 |
Chain | Residue |
I | PRO194 |
I | THR195 |
I | HIS221 |
I | ARG257 |
I | THR275 |
I | GLY276 |
I | GLY277 |
I | LEU280 |
I | ALA294 |
I | GLY295 |
I | ALA296 |
I | CYS328 |
I | GLU417 |
I | HIS447 |
I | THR492 |
I | ILE493 |
I | HOH716 |
I | HOH730 |
site_id | AD9 |
Number of Residues | 6 |
Details | binding site for residue K I 602 |
Chain | Residue |
I | ASN298 |
I | LYS332 |
I | GLU333 |
I | PHE413 |
I | VAL414 |
I | GLU416 |
site_id | AE1 |
Number of Residues | 18 |
Details | binding site for residue NAP J 601 |
Chain | Residue |
J | PRO194 |
J | THR195 |
J | THR196 |
J | HIS221 |
J | GLY222 |
J | ARG223 |
J | THR275 |
J | GLY276 |
J | ALA294 |
J | GLY295 |
J | ALA296 |
J | CYS328 |
J | THR378 |
J | GLU417 |
J | HIS447 |
J | PHE491 |
J | THR492 |
J | ILE493 |
site_id | AE2 |
Number of Residues | 6 |
Details | binding site for residue K J 602 |
Chain | Residue |
J | ASN298 |
J | LYS332 |
J | GLU333 |
J | PHE413 |
J | VAL414 |
J | GLU416 |