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6GVD

Alpha-galactosidase from Thermotoga maritima in complex with cyclohexene-based carbasugar mimic of galactose

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004557molecular_functionalpha-galactosidase activity
A0005975biological_processcarbohydrate metabolic process
A0016139biological_processglycoside catabolic process
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0030246molecular_functioncarbohydrate binding
A0042803molecular_functionprotein homodimerization activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue SO4 A 601
ChainResidue
ALYS302
AASP303
AGLU304
ALYS339

site_idAC2
Number of Residues10
Detailsbinding site for residue SO4 A 602
ChainResidue
AHOH962
AHOH994
AHOH998
AHOH1144
AHOH1391
AARG9
APHE391
AGLY393
AGLU394
AHOH788

site_idAC3
Number of Residues6
Detailsbinding site for residue MG A 603
ChainResidue
AASP419
AASP454
AHOH743
AHOH960
AHOH1059
AHOH1096

site_idAC4
Number of Residues6
Detailsbinding site for residue MG A 604
ChainResidue
AHOH840
AHOH843
AHOH858
AHOH1041
AHOH1152
AHOH1347

site_idAC5
Number of Residues7
Detailsbinding site for residue MG A 605
ChainResidue
AARG383
AILE384
AGLY385
AASP425
APRO426
AASP427
AHOH900

site_idAC6
Number of Residues15
Detailsbinding site for residue FDK A 606
ChainResidue
ASER-4
ATRP65
ATRP190
ATYR191
AASP220
AASP221
ATRP257
ALYS325
AASP327
APHE328
ACYS368
AARG383
AASP387
AHOH812
AHOH975

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:17323919
ChainResidueDetails
AASP327

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:17323919
ChainResidueDetails
AASP387

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:27783466, ECO:0007744|PDB:5M16
ChainResidueDetails
ATRP65
ATYR191
AASP220
ALYS325
ACYS368
AARG383

226707

PDB entries from 2024-10-30

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