Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6GOV

Structure of THE RNA POLYMERASE LAMBDA-BASED ANTITERMINATION COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001000	molecular_function	bacterial-type RNA polymerase core enzyme binding
A	0003676	molecular_function	nucleic acid binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006353	biological_process	DNA-templated transcription termination
A	0008023	cellular_component	transcription elongation factor complex
A	0019904	molecular_function	protein domain specific binding
A	0031554	biological_process	regulation of termination of DNA-templated transcription
A	0031564	biological_process	transcription antitermination
A	0032784	biological_process	regulation of DNA-templated transcription elongation
A	0042254	biological_process	ribosome biogenesis
A	0051259	biological_process	protein complex oligomerization
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006353	biological_process	DNA-templated transcription termination
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008023	cellular_component	transcription elongation factor complex
B	0031564	biological_process	transcription antitermination
B	0032784	biological_process	regulation of DNA-templated transcription elongation
B	0042254	biological_process	ribosome biogenesis
E	0000049	molecular_function	tRNA binding
E	0001072	molecular_function	transcription antitermination factor activity, RNA binding
E	0002181	biological_process	cytoplasmic translation
E	0003723	molecular_function	RNA binding
E	0003735	molecular_function	structural constituent of ribosome
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005840	cellular_component	ribosome
E	0006412	biological_process	translation
E	0008023	cellular_component	transcription elongation factor complex
E	0015935	cellular_component	small ribosomal subunit
E	0022627	cellular_component	cytosolic small ribosomal subunit
E	0031564	biological_process	transcription antitermination
E	0032784	biological_process	regulation of DNA-templated transcription elongation
E	0042254	biological_process	ribosome biogenesis
E	1990904	cellular_component	ribonucleoprotein complex
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0006353	biological_process	DNA-templated transcription termination
G	0006354	biological_process	DNA-templated transcription elongation
G	0008023	cellular_component	transcription elongation factor complex
G	0031564	biological_process	transcription antitermination
G	0032784	biological_process	regulation of DNA-templated transcription elongation
G	0042254	biological_process	ribosome biogenesis
G	0140673	biological_process	transcription elongation-coupled chromatin remodeling
N	0001000	molecular_function	bacterial-type RNA polymerase core enzyme binding
N	0001072	molecular_function	transcription antitermination factor activity, RNA binding
N	0003677	molecular_function	DNA binding
N	0003723	molecular_function	RNA binding
N	0003727	molecular_function	single-stranded RNA binding
N	0005515	molecular_function	protein binding
N	0006353	biological_process	DNA-templated transcription termination
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0031564	biological_process	transcription antitermination
N	0032784	biological_process	regulation of DNA-templated transcription elongation
N	0035613	molecular_function	RNA stem-loop binding
N	0070063	molecular_function	RNA polymerase binding
U	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
U	0000428	cellular_component	DNA-directed RNA polymerase complex
U	0003677	molecular_function	DNA binding
U	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0006351	biological_process	DNA-templated transcription
U	0006352	biological_process	DNA-templated transcription initiation
U	0006879	biological_process	intracellular iron ion homeostasis
U	0008023	cellular_component	transcription elongation factor complex
U	0009408	biological_process	response to heat
U	0016020	cellular_component	membrane
U	0016779	molecular_function	nucleotidyltransferase activity
U	0031564	biological_process	transcription antitermination
U	0032784	biological_process	regulation of DNA-templated transcription elongation
U	0034062	molecular_function	5'-3' RNA polymerase activity
U	0036460	biological_process	cellular response to cell envelope stress
U	0042128	biological_process	nitrate assimilation
U	0044780	biological_process	bacterial-type flagellum assembly
U	0046983	molecular_function	protein dimerization activity
U	0048870	biological_process	cell motility
U	0071973	biological_process	bacterial-type flagellum-dependent cell motility
U	0090605	biological_process	submerged biofilm formation
U	2000142	biological_process	regulation of DNA-templated transcription initiation
V	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
V	0000428	cellular_component	DNA-directed RNA polymerase complex
V	0003677	molecular_function	DNA binding
V	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
V	0005515	molecular_function	protein binding
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0006351	biological_process	DNA-templated transcription
V	0006352	biological_process	DNA-templated transcription initiation
V	0006879	biological_process	intracellular iron ion homeostasis
V	0008023	cellular_component	transcription elongation factor complex
V	0009408	biological_process	response to heat
V	0016020	cellular_component	membrane
V	0016779	molecular_function	nucleotidyltransferase activity
V	0031564	biological_process	transcription antitermination
V	0032784	biological_process	regulation of DNA-templated transcription elongation
V	0034062	molecular_function	5'-3' RNA polymerase activity
V	0036460	biological_process	cellular response to cell envelope stress
V	0042128	biological_process	nitrate assimilation
V	0044780	biological_process	bacterial-type flagellum assembly
V	0046983	molecular_function	protein dimerization activity
V	0048870	biological_process	cell motility
V	0071973	biological_process	bacterial-type flagellum-dependent cell motility
V	0090605	biological_process	submerged biofilm formation
V	2000142	biological_process	regulation of DNA-templated transcription initiation
W	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
W	0000428	cellular_component	DNA-directed RNA polymerase complex
W	0001000	molecular_function	bacterial-type RNA polymerase core enzyme binding
W	0003677	molecular_function	DNA binding
W	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
W	0005829	cellular_component	cytosol
W	0006351	biological_process	DNA-templated transcription
W	0006352	biological_process	DNA-templated transcription initiation
W	0006879	biological_process	intracellular iron ion homeostasis
W	0008023	cellular_component	transcription elongation factor complex
W	0009408	biological_process	response to heat
W	0016779	molecular_function	nucleotidyltransferase activity
W	0030880	cellular_component	RNA polymerase complex
W	0031564	biological_process	transcription antitermination
W	0032784	biological_process	regulation of DNA-templated transcription elongation
W	0034062	molecular_function	5'-3' RNA polymerase activity
W	0036460	biological_process	cellular response to cell envelope stress
W	0042128	biological_process	nitrate assimilation
W	0044780	biological_process	bacterial-type flagellum assembly
W	0048870	biological_process	cell motility
W	0065003	biological_process	protein-containing complex assembly
W	0071973	biological_process	bacterial-type flagellum-dependent cell motility
W	0090605	biological_process	submerged biofilm formation
W	2000142	biological_process	regulation of DNA-templated transcription initiation
X	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
X	0000428	cellular_component	DNA-directed RNA polymerase complex
X	0003677	molecular_function	DNA binding
X	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0006351	biological_process	DNA-templated transcription
X	0006352	biological_process	DNA-templated transcription initiation
X	0006879	biological_process	intracellular iron ion homeostasis
X	0008023	cellular_component	transcription elongation factor complex
X	0009408	biological_process	response to heat
X	0016020	cellular_component	membrane
X	0016779	molecular_function	nucleotidyltransferase activity
X	0031564	biological_process	transcription antitermination
X	0032549	molecular_function	ribonucleoside binding
X	0032784	biological_process	regulation of DNA-templated transcription elongation
X	0034062	molecular_function	5'-3' RNA polymerase activity
X	0036460	biological_process	cellular response to cell envelope stress
X	0042128	biological_process	nitrate assimilation
X	0044780	biological_process	bacterial-type flagellum assembly
X	0046677	biological_process	response to antibiotic
X	0048870	biological_process	cell motility
X	0071973	biological_process	bacterial-type flagellum-dependent cell motility
X	0090605	biological_process	submerged biofilm formation
X	2000142	biological_process	regulation of DNA-templated transcription initiation
Y	0000287	molecular_function	magnesium ion binding
Y	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
Y	0000428	cellular_component	DNA-directed RNA polymerase complex
Y	0003677	molecular_function	DNA binding
Y	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
Y	0005515	molecular_function	protein binding
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0006351	biological_process	DNA-templated transcription
Y	0006352	biological_process	DNA-templated transcription initiation
Y	0006879	biological_process	intracellular iron ion homeostasis
Y	0008023	cellular_component	transcription elongation factor complex
Y	0008270	molecular_function	zinc ion binding
Y	0009408	biological_process	response to heat
Y	0016020	cellular_component	membrane
Y	0016779	molecular_function	nucleotidyltransferase activity
Y	0031564	biological_process	transcription antitermination
Y	0032784	biological_process	regulation of DNA-templated transcription elongation
Y	0034062	molecular_function	5'-3' RNA polymerase activity
Y	0036460	biological_process	cellular response to cell envelope stress
Y	0042128	biological_process	nitrate assimilation
Y	0044780	biological_process	bacterial-type flagellum assembly
Y	0046677	biological_process	response to antibiotic
Y	0046872	molecular_function	metal ion binding
Y	0048870	biological_process	cell motility
Y	0071973	biological_process	bacterial-type flagellum-dependent cell motility
Y	0090605	biological_process	submerged biofilm formation
Y	2000142	biological_process	regulation of DNA-templated transcription initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG Y 1501

Chain	Residue
R	C66
Y	ASP460
Y	ASP462
Y	ASP464

site_id	AC2
Number of Residues	5
Details	binding site for residue ZN Y 1502

Chain	Residue
Y	CYS70
Y	CYS72
Y	CYS85
Y	LYS87
Y	CYS88

site_id	AC3
Number of Residues	5
Details	binding site for residue ZN Y 1503

Chain	Residue
Y	CYS814
Y	CYS888
Y	ASP889
Y	CYS895
Y	CYS898

Functional Information from PROSITE/UniProt

site_id	PS00361
Number of Residues	16
Details	RIBOSOMAL_S10 Ribosomal protein S10 signature. AkrtGAqvrGPIpLPT

Chain	Residue	Details
E	ALA29-THR44

site_id	PS01014
Number of Residues	10
Details	NUSG Transcription termination factor nusG signature. IFGRaTPVeL

Chain	Residue	Details
G	ILE164-LEU173

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKMAGrHGNKGV

Chain	Residue	Details
X	GLY1063-VAL1075

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	BINDING: BINDING => ECO:0000269\|PubMed:32871103, ECO:0007744\|PDB:4MEX, ECO:0007744\|PDB:4MEY

Chain	Residue	Details
Y	CYS70
Y	CYS895
Y	CYS898
Y	CYS72
Y	CYS85
Y	CYS88
Y	ASP460
Y	ASP462
Y	ASP464
Y	CYS814
Y	CYS888

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000255\|HAMAP-Rule:MF_01322

Chain	Residue	Details
Y	LYS972
V	LYS297

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000255\|HAMAP-Rule:MF_01322, ECO:0000269\|PubMed:18723842

Chain	Residue	Details
Y	LYS983
V	LYS298

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)