6GOA

Structural basis for OXA-48 dimerization - R189A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0046677	biological_process	response to antibiotic
A	0071555	biological_process	cell wall organization
B	0005886	cellular_component	plasma membrane
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0046677	biological_process	response to antibiotic
B	0071555	biological_process	cell wall organization
C	0005886	cellular_component	plasma membrane
C	0008658	molecular_function	penicillin binding
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0046677	biological_process	response to antibiotic
C	0071555	biological_process	cell wall organization
D	0005886	cellular_component	plasma membrane
D	0008658	molecular_function	penicillin binding
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0046677	biological_process	response to antibiotic
D	0071555	biological_process	cell wall organization
E	0005886	cellular_component	plasma membrane
E	0008658	molecular_function	penicillin binding
E	0008800	molecular_function	beta-lactamase activity
E	0016787	molecular_function	hydrolase activity
E	0017001	biological_process	antibiotic catabolic process
E	0046677	biological_process	response to antibiotic
E	0071555	biological_process	cell wall organization
F	0005886	cellular_component	plasma membrane
F	0008658	molecular_function	penicillin binding
F	0008800	molecular_function	beta-lactamase activity
F	0016787	molecular_function	hydrolase activity
F	0017001	biological_process	antibiotic catabolic process
F	0046677	biological_process	response to antibiotic
F	0071555	biological_process	cell wall organization
G	0005886	cellular_component	plasma membrane
G	0008658	molecular_function	penicillin binding
G	0008800	molecular_function	beta-lactamase activity
G	0016787	molecular_function	hydrolase activity
G	0017001	biological_process	antibiotic catabolic process
G	0046677	biological_process	response to antibiotic
G	0071555	biological_process	cell wall organization
H	0005886	cellular_component	plasma membrane
H	0008658	molecular_function	penicillin binding
H	0008800	molecular_function	beta-lactamase activity
H	0016787	molecular_function	hydrolase activity
H	0017001	biological_process	antibiotic catabolic process
H	0046677	biological_process	response to antibiotic
H	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue CL A 301

Chain	Residue
A	ARG206
D	ARG206

---

site_id	AC2
Number of Residues	2
Details	binding site for residue CL B 301

Chain	Residue
B	THR209
B	ARG250

---

site_id	AC3
Number of Residues	2
Details	binding site for residue CL C 301

Chain	Residue
B	ARG206
C	ARG206

---

site_id	AC4
Number of Residues	1
Details	binding site for residue CL C 302

Chain	Residue
C	ARG250

---

site_id	AC5
Number of Residues	2
Details	binding site for residue CL E 301

Chain	Residue
E	ARG206
H	ARG206

---

site_id	AC6
Number of Residues	2
Details	binding site for residue CL G 301

Chain	Residue
F	ARG206
G	ARG206

---

site_id	AC7
Number of Residues	2
Details	binding site for residue CL G 302

Chain	Residue
G	THR209
G	ARG250

---

site_id	AC8
Number of Residues	2
Details	binding site for residue CL H 301

Chain	Residue
H	THR209
H	ARG250

---

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnSL

Chain	Residue	Details
A	PRO68-LEU78

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26731698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31358584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32150407","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V1O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8RLA6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P13661","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19477418","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---