6GLC

Structure of phospho-Parkin bound to phospho-ubiquitin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	CYS253
A	HIS257
A	CYS289
A	CYS293

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 502

Chain	Residue
A	CYS365
A	CYS368
A	HIS373
A	CYS377

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 503

Chain	Residue
A	CYS169
A	CYS196
A	CYS201
A	CYS166

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 504

Chain	Residue
A	CYS238
A	CYS241
A	CYS260
A	CYS263

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN A 505

Chain	Residue
A	CYS332
A	CYS337
A	CYS352
A	CYS360

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN A 506

Chain	Residue
A	CYS150
A	CYS154
A	CYS212
A	HIS215

---

site_id	AC7
Number of Residues	3
Details	binding site for residue GOL A 507

Chain	Residue
A	PRO14
A	GLU16
A	CYS263

---

site_id	AC8
Number of Residues	3
Details	binding site for residue GOL A 508

Chain	Residue
A	PRO14
A	ARG245
A	CYS263

---

site_id	AC9
Number of Residues	6
Details	binding site for residue GOL A 509

Chain	Residue
A	PHE4
A	GLY12
A	ILE66
A	SER218
A	THR242
A	HOH649

---

site_id	AD1
Number of Residues	7
Details	binding site for residue MPD A 510

Chain	Residue
A	LYS299
A	GLU300
A	LEU301
A	HIS302
B	PHE45
B	ASP58
B	TYR59

---

site_id	AD2
Number of Residues	3
Details	binding site for residue SO4 B 101

Chain	Residue
B	ARG42
B	ARG72
B	ARG74

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
B	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
B	ARG54
B	ARG72

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Essential for function

Chain	Residue	Details
B	HIS68

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291

Chain	Residue	Details
B	SEP65

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457

Chain	Residue	Details
B	THR66
A	CYS241
A	CYS253
A	HIS257
A	CYS260
A	CYS263
A	CYS289
A	CYS293
A	HIS373

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742

Chain	Residue	Details
B	3CN76
A	CYS337
A	CYS352
A	CYS360
A	CYS365
A	CYS368
A	CYS377

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603

Chain	Residue	Details
B	LYS6

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
A	THR175
B	3CN76

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144

Chain	Residue	Details
B	LYS11
B	LYS48

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860

Chain	Residue	Details
B	LYS27
A	LYS369

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127

Chain	Residue	Details
B	LYS29

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577

Chain	Residue	Details
B	LYS33

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106

Chain	Residue	Details
B	LYS63

---