6GL4
Structure of GluA2o ligand-binding domain (S1S2J) in complex with glutamate and sodium bromide at 1.95 A resolution
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue GLU A 301 |
| Chain | Residue |
| A | TYR61 |
| A | HOH453 |
| A | HOH457 |
| A | HOH498 |
| A | PRO89 |
| A | LEU90 |
| A | THR91 |
| A | ARG96 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| A | GLU193 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue BR A 302 |
| Chain | Residue |
| A | HOH465 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue BR A 303 |
| Chain | Residue |
| A | THR93 |
| A | VAL95 |
| A | HOH574 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | SER217 |
| A | LYS218 |
| A | HOH441 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for residue GLU B 301 |
| Chain | Residue |
| B | TYR61 |
| B | PRO89 |
| B | LEU90 |
| B | THR91 |
| B | ARG96 |
| B | GLY141 |
| B | SER142 |
| B | THR143 |
| B | GLU193 |
| B | HOH413 |
| B | HOH476 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue BR B 303 |
| Chain | Residue |
| B | THR93 |
| B | HOH471 |
| B | HOH608 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue BR B 304 |
| Chain | Residue |
| B | SER108 |
| B | HOH489 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 305 |
| Chain | Residue |
| B | ARG182 |
| B | ILE200 |
| B | ARG203 |
| B | PRO205 |
| B | HOH484 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 306 |
| Chain | Residue |
| B | ASN242 |
| B | HOH424 |
| B | HOH499 |
| B | HOH573 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 307 |
| Chain | Residue |
| B | ASN214 |
| B | LEU215 |
| B | ASP216 |
| B | SER217 |
| B | HOH508 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
