6GKY

Crystal structure of Coclaurine N-Methyltransferase (CNMT) bound to N-methylheliamine and SAH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0030776	molecular_function	(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0030776	molecular_function	(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue SAH A 501

Chain	Residue
A	VAL73
A	ASP187
A	ILE188
A	ILE203
A	GLU204
A	LEU205
A	MET209
A	TYR81
A	GLY98
A	SER99
A	GLY137
A	CYS138
A	GLY139
A	ASN161
A	GLN165

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site_id	AC2
Number of Residues	5
Details	binding site for residue F2Z A 502

Chain	Residue
A	TYR81
A	GLU204
A	HIS208
A	PHE257
A	PHE290

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site_id	AC3
Number of Residues	13
Details	binding site for residue SAH B 501

Chain	Residue
B	TYR81
B	GLY98
B	SER99
B	GLY137
B	CYS138
B	GLY139
B	ASN161
B	GLN165
B	ASP187
B	ILE188
B	ILE203
B	GLU204
B	LEU205

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site_id	AC4
Number of Residues	6
Details	binding site for residue F2Z B 502

Chain	Residue
B	TYR81
B	GLU204
B	HIS208
B	ILE234
B	PHE257
B	PHE290

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