6GKY
Crystal structure of Coclaurine N-Methyltransferase (CNMT) bound to N-methylheliamine and SAH
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0030776 | molecular_function | (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity |
A | 0032259 | biological_process | methylation |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0030776 | molecular_function | (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity |
B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | binding site for residue SAH A 501 |
Chain | Residue |
A | VAL73 |
A | ASP187 |
A | ILE188 |
A | ILE203 |
A | GLU204 |
A | LEU205 |
A | MET209 |
A | TYR81 |
A | GLY98 |
A | SER99 |
A | GLY137 |
A | CYS138 |
A | GLY139 |
A | ASN161 |
A | GLN165 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue F2Z A 502 |
Chain | Residue |
A | TYR81 |
A | GLU204 |
A | HIS208 |
A | PHE257 |
A | PHE290 |
site_id | AC3 |
Number of Residues | 13 |
Details | binding site for residue SAH B 501 |
Chain | Residue |
B | TYR81 |
B | GLY98 |
B | SER99 |
B | GLY137 |
B | CYS138 |
B | GLY139 |
B | ASN161 |
B | GLN165 |
B | ASP187 |
B | ILE188 |
B | ILE203 |
B | GLU204 |
B | LEU205 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue F2Z B 502 |
Chain | Residue |
B | TYR81 |
B | GLU204 |
B | HIS208 |
B | ILE234 |
B | PHE257 |
B | PHE290 |