6GKY
Crystal structure of Coclaurine N-Methyltransferase (CNMT) bound to N-methylheliamine and SAH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0030776 | molecular_function | (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0030776 | molecular_function | (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue SAH A 501 |
| Chain | Residue |
| A | VAL73 |
| A | ASP187 |
| A | ILE188 |
| A | ILE203 |
| A | GLU204 |
| A | LEU205 |
| A | MET209 |
| A | TYR81 |
| A | GLY98 |
| A | SER99 |
| A | GLY137 |
| A | CYS138 |
| A | GLY139 |
| A | ASN161 |
| A | GLN165 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue F2Z A 502 |
| Chain | Residue |
| A | TYR81 |
| A | GLU204 |
| A | HIS208 |
| A | PHE257 |
| A | PHE290 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue SAH B 501 |
| Chain | Residue |
| B | TYR81 |
| B | GLY98 |
| B | SER99 |
| B | GLY137 |
| B | CYS138 |
| B | GLY139 |
| B | ASN161 |
| B | GLN165 |
| B | ASP187 |
| B | ILE188 |
| B | ILE203 |
| B | GLU204 |
| B | LEU205 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue F2Z B 502 |
| Chain | Residue |
| B | TYR81 |
| B | GLU204 |
| B | HIS208 |
| B | ILE234 |
| B | PHE257 |
| B | PHE290 |
