6GKT

X-ray structure of a non-autocrystallizing galectin-10 variant, Gal10-Tyr69Glu

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002667	biological_process	regulation of T cell anergy
A	0002724	biological_process	regulation of T cell cytokine production
A	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0030246	molecular_function	carbohydrate binding
A	0031012	cellular_component	extracellular matrix
A	0042802	molecular_function	identical protein binding
A	0046006	biological_process	regulation of activated T cell proliferation
A	0070231	biological_process	T cell apoptotic process
B	0002667	biological_process	regulation of T cell anergy
B	0002724	biological_process	regulation of T cell cytokine production
B	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0030246	molecular_function	carbohydrate binding
B	0031012	cellular_component	extracellular matrix
B	0042802	molecular_function	identical protein binding
B	0046006	biological_process	regulation of activated T cell proliferation
B	0070231	biological_process	T cell apoptotic process
C	0002667	biological_process	regulation of T cell anergy
C	0002724	biological_process	regulation of T cell cytokine production
C	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0030246	molecular_function	carbohydrate binding
C	0031012	cellular_component	extracellular matrix
C	0042802	molecular_function	identical protein binding
C	0046006	biological_process	regulation of activated T cell proliferation
C	0070231	biological_process	T cell apoptotic process
D	0002667	biological_process	regulation of T cell anergy
D	0002724	biological_process	regulation of T cell cytokine production
D	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0030246	molecular_function	carbohydrate binding
D	0031012	cellular_component	extracellular matrix
D	0042802	molecular_function	identical protein binding
D	0046006	biological_process	regulation of activated T cell proliferation
D	0070231	biological_process	T cell apoptotic process
E	0002667	biological_process	regulation of T cell anergy
E	0002724	biological_process	regulation of T cell cytokine production
E	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0030246	molecular_function	carbohydrate binding
E	0031012	cellular_component	extracellular matrix
E	0042802	molecular_function	identical protein binding
E	0046006	biological_process	regulation of activated T cell proliferation
E	0070231	biological_process	T cell apoptotic process
F	0002667	biological_process	regulation of T cell anergy
F	0002724	biological_process	regulation of T cell cytokine production
F	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0030246	molecular_function	carbohydrate binding
F	0031012	cellular_component	extracellular matrix
F	0042802	molecular_function	identical protein binding
F	0046006	biological_process	regulation of activated T cell proliferation
F	0070231	biological_process	T cell apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue PGE A 201

Chain	Residue
A	TYR35
A	HIS53
A	GLN55
A	TRP72
A	ARG128
A	HOH348
A	HOH354
B	GLU33
B	TYR35

---

site_id	AC2
Number of Residues	3
Details	binding site for residue PGE A 202

Chain	Residue
A	LEU4
A	HOH372
B	LEU4

---

site_id	AC3
Number of Residues	8
Details	binding site for residue PG4 B 201

Chain	Residue
A	LEU27
A	ALA28
A	ASN32
B	THR9
B	MET44
B	GLU46
B	GLN125
B	HOH324

---

site_id	AC4
Number of Residues	9
Details	binding site for residue PGE B 202

Chain	Residue
A	GLU33
A	TYR35
B	HIS53
B	GLN55
B	VAL63
B	ASN65
B	GLN75
B	ARG128
B	HOH376

---

site_id	AC5
Number of Residues	6
Details	binding site for residue PGE C 201

Chain	Residue
B	GLN107
C	THR21
C	LYS23
C	GLU90
C	LYS134
C	ASN136

---

site_id	AC6
Number of Residues	3
Details	binding site for residue PGE C 202

Chain	Residue
C	GLU43
C	LYS45
F	ASP85

---

site_id	AC7
Number of Residues	8
Details	binding site for residue P6G E 201

Chain	Residue
E	MET44
E	GLU46
E	GLN125
E	TRP127
E	HOH313
F	LEU27
F	ALA28
F	ASN32

---

site_id	AC8
Number of Residues	3
Details	binding site for residue PGE E 202

Chain	Residue
E	LEU3
E	LEU4
F	LEU4

---

site_id	AC9
Number of Residues	3
Details	binding site for residue PGE F 201

Chain	Residue
F	THR9
F	MET44
F	PGE202

---

site_id	AD1
Number of Residues	10
Details	binding site for residue PGE F 202

Chain	Residue
E	LEU27
E	ALA28
E	ASN32
F	PRO7
F	ASP39
F	HIS41
F	GLU46
F	GLN125
F	TRP127
F	PGE201

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	792
Details	Domain: {"description":"Galectin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00639","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Site: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"16457599","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"16457599","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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