Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6GKG

Structure of 14-3-3 gamma in complex with caspase-2 14-3-3 binding motif Ser164

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005080	molecular_function	protein kinase C binding
A	0005159	molecular_function	insulin-like growth factor receptor binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0006469	biological_process	negative regulation of protein kinase activity
A	0006605	biological_process	protein targeting
A	0007165	biological_process	signal transduction
A	0008104	biological_process	protein localization
A	0008426	molecular_function	protein kinase C inhibitor activity
A	0009966	biological_process	regulation of signal transduction
A	0016020	cellular_component	membrane
A	0019904	molecular_function	protein domain specific binding
A	0030971	molecular_function	receptor tyrosine kinase binding
A	0031982	cellular_component	vesicle
A	0032869	biological_process	cellular response to insulin stimulus
A	0042149	biological_process	cellular response to glucose starvation
A	0042802	molecular_function	identical protein binding
A	0045202	cellular_component	synapse
A	0045664	biological_process	regulation of neuron differentiation
A	0048167	biological_process	regulation of synaptic plasticity
A	0070062	cellular_component	extracellular exosome
A	0098793	cellular_component	presynapse
A	0140031	molecular_function	phosphorylation-dependent protein binding
A	0140311	molecular_function	protein sequestering activity
A	1904262	biological_process	negative regulation of TORC1 signaling
B	0003723	molecular_function	RNA binding
B	0005080	molecular_function	protein kinase C binding
B	0005159	molecular_function	insulin-like growth factor receptor binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005925	cellular_component	focal adhesion
B	0006469	biological_process	negative regulation of protein kinase activity
B	0006605	biological_process	protein targeting
B	0007165	biological_process	signal transduction
B	0008104	biological_process	protein localization
B	0008426	molecular_function	protein kinase C inhibitor activity
B	0009966	biological_process	regulation of signal transduction
B	0016020	cellular_component	membrane
B	0019904	molecular_function	protein domain specific binding
B	0030971	molecular_function	receptor tyrosine kinase binding
B	0031982	cellular_component	vesicle
B	0032869	biological_process	cellular response to insulin stimulus
B	0042149	biological_process	cellular response to glucose starvation
B	0042802	molecular_function	identical protein binding
B	0045202	cellular_component	synapse
B	0045664	biological_process	regulation of neuron differentiation
B	0048167	biological_process	regulation of synaptic plasticity
B	0070062	cellular_component	extracellular exosome
B	0098793	cellular_component	presynapse
B	0140031	molecular_function	phosphorylation-dependent protein binding
B	0140311	molecular_function	protein sequestering activity
B	1904262	biological_process	negative regulation of TORC1 signaling
C	0003723	molecular_function	RNA binding
C	0005080	molecular_function	protein kinase C binding
C	0005159	molecular_function	insulin-like growth factor receptor binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005925	cellular_component	focal adhesion
C	0006469	biological_process	negative regulation of protein kinase activity
C	0006605	biological_process	protein targeting
C	0007165	biological_process	signal transduction
C	0008104	biological_process	protein localization
C	0008426	molecular_function	protein kinase C inhibitor activity
C	0009966	biological_process	regulation of signal transduction
C	0016020	cellular_component	membrane
C	0019904	molecular_function	protein domain specific binding
C	0030971	molecular_function	receptor tyrosine kinase binding
C	0031982	cellular_component	vesicle
C	0032869	biological_process	cellular response to insulin stimulus
C	0042149	biological_process	cellular response to glucose starvation
C	0042802	molecular_function	identical protein binding
C	0045202	cellular_component	synapse
C	0045664	biological_process	regulation of neuron differentiation
C	0048167	biological_process	regulation of synaptic plasticity
C	0070062	cellular_component	extracellular exosome
C	0098793	cellular_component	presynapse
C	0140031	molecular_function	phosphorylation-dependent protein binding
C	0140311	molecular_function	protein sequestering activity
C	1904262	biological_process	negative regulation of TORC1 signaling
D	0003723	molecular_function	RNA binding
D	0005080	molecular_function	protein kinase C binding
D	0005159	molecular_function	insulin-like growth factor receptor binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005925	cellular_component	focal adhesion
D	0006469	biological_process	negative regulation of protein kinase activity
D	0006605	biological_process	protein targeting
D	0007165	biological_process	signal transduction
D	0008104	biological_process	protein localization
D	0008426	molecular_function	protein kinase C inhibitor activity
D	0009966	biological_process	regulation of signal transduction
D	0016020	cellular_component	membrane
D	0019904	molecular_function	protein domain specific binding
D	0030971	molecular_function	receptor tyrosine kinase binding
D	0031982	cellular_component	vesicle
D	0032869	biological_process	cellular response to insulin stimulus
D	0042149	biological_process	cellular response to glucose starvation
D	0042802	molecular_function	identical protein binding
D	0045202	cellular_component	synapse
D	0045664	biological_process	regulation of neuron differentiation
D	0048167	biological_process	regulation of synaptic plasticity
D	0070062	cellular_component	extracellular exosome
D	0098793	cellular_component	presynapse
D	0140031	molecular_function	phosphorylation-dependent protein binding
D	0140311	molecular_function	protein sequestering activity
D	1904262	biological_process	negative regulation of TORC1 signaling
E	0003723	molecular_function	RNA binding
E	0005080	molecular_function	protein kinase C binding
E	0005159	molecular_function	insulin-like growth factor receptor binding
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005925	cellular_component	focal adhesion
E	0006469	biological_process	negative regulation of protein kinase activity
E	0006605	biological_process	protein targeting
E	0007165	biological_process	signal transduction
E	0008104	biological_process	protein localization
E	0008426	molecular_function	protein kinase C inhibitor activity
E	0009966	biological_process	regulation of signal transduction
E	0016020	cellular_component	membrane
E	0019904	molecular_function	protein domain specific binding
E	0030971	molecular_function	receptor tyrosine kinase binding
E	0031982	cellular_component	vesicle
E	0032869	biological_process	cellular response to insulin stimulus
E	0042149	biological_process	cellular response to glucose starvation
E	0042802	molecular_function	identical protein binding
E	0045202	cellular_component	synapse
E	0045664	biological_process	regulation of neuron differentiation
E	0048167	biological_process	regulation of synaptic plasticity
E	0070062	cellular_component	extracellular exosome
E	0098793	cellular_component	presynapse
E	0140031	molecular_function	phosphorylation-dependent protein binding
E	0140311	molecular_function	protein sequestering activity
E	1904262	biological_process	negative regulation of TORC1 signaling
F	0003723	molecular_function	RNA binding
F	0005080	molecular_function	protein kinase C binding
F	0005159	molecular_function	insulin-like growth factor receptor binding
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005925	cellular_component	focal adhesion
F	0006469	biological_process	negative regulation of protein kinase activity
F	0006605	biological_process	protein targeting
F	0007165	biological_process	signal transduction
F	0008104	biological_process	protein localization
F	0008426	molecular_function	protein kinase C inhibitor activity
F	0009966	biological_process	regulation of signal transduction
F	0016020	cellular_component	membrane
F	0019904	molecular_function	protein domain specific binding
F	0030971	molecular_function	receptor tyrosine kinase binding
F	0031982	cellular_component	vesicle
F	0032869	biological_process	cellular response to insulin stimulus
F	0042149	biological_process	cellular response to glucose starvation
F	0042802	molecular_function	identical protein binding
F	0045202	cellular_component	synapse
F	0045664	biological_process	regulation of neuron differentiation
F	0048167	biological_process	regulation of synaptic plasticity
F	0070062	cellular_component	extracellular exosome
F	0098793	cellular_component	presynapse
F	0140031	molecular_function	phosphorylation-dependent protein binding
F	0140311	molecular_function	protein sequestering activity
F	1904262	biological_process	negative regulation of TORC1 signaling
G	0003723	molecular_function	RNA binding
G	0005080	molecular_function	protein kinase C binding
G	0005159	molecular_function	insulin-like growth factor receptor binding
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005925	cellular_component	focal adhesion
G	0006469	biological_process	negative regulation of protein kinase activity
G	0006605	biological_process	protein targeting
G	0007165	biological_process	signal transduction
G	0008104	biological_process	protein localization
G	0008426	molecular_function	protein kinase C inhibitor activity
G	0009966	biological_process	regulation of signal transduction
G	0016020	cellular_component	membrane
G	0019904	molecular_function	protein domain specific binding
G	0030971	molecular_function	receptor tyrosine kinase binding
G	0031982	cellular_component	vesicle
G	0032869	biological_process	cellular response to insulin stimulus
G	0042149	biological_process	cellular response to glucose starvation
G	0042802	molecular_function	identical protein binding
G	0045202	cellular_component	synapse
G	0045664	biological_process	regulation of neuron differentiation
G	0048167	biological_process	regulation of synaptic plasticity
G	0070062	cellular_component	extracellular exosome
G	0098793	cellular_component	presynapse
G	0140031	molecular_function	phosphorylation-dependent protein binding
G	0140311	molecular_function	protein sequestering activity
G	1904262	biological_process	negative regulation of TORC1 signaling
H	0003723	molecular_function	RNA binding
H	0005080	molecular_function	protein kinase C binding
H	0005159	molecular_function	insulin-like growth factor receptor binding
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005925	cellular_component	focal adhesion
H	0006469	biological_process	negative regulation of protein kinase activity
H	0006605	biological_process	protein targeting
H	0007165	biological_process	signal transduction
H	0008104	biological_process	protein localization
H	0008426	molecular_function	protein kinase C inhibitor activity
H	0009966	biological_process	regulation of signal transduction
H	0016020	cellular_component	membrane
H	0019904	molecular_function	protein domain specific binding
H	0030971	molecular_function	receptor tyrosine kinase binding
H	0031982	cellular_component	vesicle
H	0032869	biological_process	cellular response to insulin stimulus
H	0042149	biological_process	cellular response to glucose starvation
H	0042802	molecular_function	identical protein binding
H	0045202	cellular_component	synapse
H	0045664	biological_process	regulation of neuron differentiation
H	0048167	biological_process	regulation of synaptic plasticity
H	0070062	cellular_component	extracellular exosome
H	0098793	cellular_component	presynapse
H	0140031	molecular_function	phosphorylation-dependent protein binding
H	0140311	molecular_function	protein sequestering activity
H	1904262	biological_process	negative regulation of TORC1 signaling

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG42-VAL52

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	SITE: Interaction with phosphoserine on interacting protein => ECO:0000269\|PubMed:17085597

Chain	Residue	Details
A	ARG57
E	ARG132
F	ARG57
F	ARG132
G	ARG57
G	ARG132
H	ARG57
H	ARG132
A	ARG132
B	ARG57
B	ARG132
C	ARG57
C	ARG132
D	ARG57
D	ARG132
E	ARG57

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: N-acetylmethionine; in 14-3-3 protein gamma; alternate; partial => ECO:0000269\|Ref.7

Chain	Residue	Details
A	MET1
B	MET1
C	MET1
D	MET1
E	MET1
F	MET1
G	MET1
H	MET1

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: N-acetylvaline; partial => ECO:0000269\|PubMed:14534293, ECO:0000269\|Ref.7, ECO:0000269\|Ref.9, ECO:0007744\|PubMed:19413330

Chain	Residue	Details
A	VAL2
B	VAL2
C	VAL2
D	VAL2
E	VAL2
F	VAL2
G	VAL2
H	VAL2

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER71
B	SER71
C	SER71
D	SER71
E	SER71
F	SER71
G	SER71
H	SER71

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P61983

Chain	Residue	Details
A	TYR133
B	TYR133
C	TYR133
D	TYR133
E	TYR133
F	TYR133
G	TYR133
H	TYR133

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0000269\|Ref.7

Chain	Residue	Details
A	THR145
B	THR145
C	THR145
D	THR145
E	THR145
F	THR145
G	THR145
H	THR145

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P61983

Chain	Residue	Details
A	SER215
B	SER215
C	SER215
D	SER215
E	SER215
F	SER215
G	SER215
H	SER215

site_id	SWS_FT_FI8
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	THR234
B	THR234
C	THR234
D	THR234
E	THR234
F	THR234
G	THR234
H	THR234

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)