6GKF

Structure of 14-3-3 gamma in complex with caspase-2 14-3-3 binding motif Ser139

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002181	biological_process	cytoplasmic translation
A	0002841	biological_process	negative regulation of T cell mediated immune response to tumor cell
A	0002842	biological_process	positive regulation of T cell mediated immune response to tumor cell
A	0003723	molecular_function	RNA binding
A	0005080	molecular_function	protein kinase C binding
A	0005159	molecular_function	insulin-like growth factor receptor binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0006469	biological_process	negative regulation of protein kinase activity
A	0006605	biological_process	protein targeting
A	0007165	biological_process	signal transduction
A	0008104	biological_process	protein localization
A	0008426	molecular_function	protein kinase C inhibitor activity
A	0009966	biological_process	regulation of signal transduction
A	0016020	cellular_component	membrane
A	0019904	molecular_function	protein domain specific binding
A	0022409	biological_process	positive regulation of cell-cell adhesion
A	0030971	molecular_function	receptor tyrosine kinase binding
A	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A	0031669	biological_process	cellular response to nutrient levels
A	0031982	cellular_component	vesicle
A	0032869	biological_process	cellular response to insulin stimulus
A	0032880	biological_process	regulation of protein localization
A	0034198	biological_process	cellular response to amino acid starvation
A	0038202	biological_process	TORC1 signaling
A	0042149	biological_process	cellular response to glucose starvation
A	0042802	molecular_function	identical protein binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0045202	cellular_component	synapse
A	0045664	biological_process	regulation of neuron differentiation
A	0045947	biological_process	negative regulation of translational initiation
A	0045948	biological_process	positive regulation of translational initiation
A	0048167	biological_process	regulation of synaptic plasticity
A	0050821	biological_process	protein stabilization
A	0050868	biological_process	negative regulation of T cell activation
A	0050870	biological_process	positive regulation of T cell activation
A	0061462	biological_process	protein localization to lysosome
A	0070062	cellular_component	extracellular exosome
A	0085020	biological_process	protein K6-linked ubiquitination
A	0098793	cellular_component	presynapse
A	0140031	molecular_function	phosphorylation-dependent protein binding
A	0140311	molecular_function	protein sequestering activity
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1904263	biological_process	positive regulation of TORC1 signaling
B	0002181	biological_process	cytoplasmic translation
B	0002841	biological_process	negative regulation of T cell mediated immune response to tumor cell
B	0002842	biological_process	positive regulation of T cell mediated immune response to tumor cell
B	0003723	molecular_function	RNA binding
B	0005080	molecular_function	protein kinase C binding
B	0005159	molecular_function	insulin-like growth factor receptor binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0005925	cellular_component	focal adhesion
B	0006469	biological_process	negative regulation of protein kinase activity
B	0006605	biological_process	protein targeting
B	0007165	biological_process	signal transduction
B	0008104	biological_process	protein localization
B	0008426	molecular_function	protein kinase C inhibitor activity
B	0009966	biological_process	regulation of signal transduction
B	0016020	cellular_component	membrane
B	0019904	molecular_function	protein domain specific binding
B	0022409	biological_process	positive regulation of cell-cell adhesion
B	0030971	molecular_function	receptor tyrosine kinase binding
B	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B	0031669	biological_process	cellular response to nutrient levels
B	0031982	cellular_component	vesicle
B	0032869	biological_process	cellular response to insulin stimulus
B	0032880	biological_process	regulation of protein localization
B	0034198	biological_process	cellular response to amino acid starvation
B	0038202	biological_process	TORC1 signaling
B	0042149	biological_process	cellular response to glucose starvation
B	0042802	molecular_function	identical protein binding
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0045202	cellular_component	synapse
B	0045664	biological_process	regulation of neuron differentiation
B	0045947	biological_process	negative regulation of translational initiation
B	0045948	biological_process	positive regulation of translational initiation
B	0048167	biological_process	regulation of synaptic plasticity
B	0050821	biological_process	protein stabilization
B	0050868	biological_process	negative regulation of T cell activation
B	0050870	biological_process	positive regulation of T cell activation
B	0061462	biological_process	protein localization to lysosome
B	0070062	cellular_component	extracellular exosome
B	0085020	biological_process	protein K6-linked ubiquitination
B	0098793	cellular_component	presynapse
B	0140031	molecular_function	phosphorylation-dependent protein binding
B	0140311	molecular_function	protein sequestering activity
B	1904262	biological_process	negative regulation of TORC1 signaling
B	1904263	biological_process	positive regulation of TORC1 signaling
C	0002181	biological_process	cytoplasmic translation
C	0002841	biological_process	negative regulation of T cell mediated immune response to tumor cell
C	0002842	biological_process	positive regulation of T cell mediated immune response to tumor cell
C	0003723	molecular_function	RNA binding
C	0005080	molecular_function	protein kinase C binding
C	0005159	molecular_function	insulin-like growth factor receptor binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0005925	cellular_component	focal adhesion
C	0006469	biological_process	negative regulation of protein kinase activity
C	0006605	biological_process	protein targeting
C	0007165	biological_process	signal transduction
C	0008104	biological_process	protein localization
C	0008426	molecular_function	protein kinase C inhibitor activity
C	0009966	biological_process	regulation of signal transduction
C	0016020	cellular_component	membrane
C	0019904	molecular_function	protein domain specific binding
C	0022409	biological_process	positive regulation of cell-cell adhesion
C	0030971	molecular_function	receptor tyrosine kinase binding
C	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C	0031669	biological_process	cellular response to nutrient levels
C	0031982	cellular_component	vesicle
C	0032869	biological_process	cellular response to insulin stimulus
C	0032880	biological_process	regulation of protein localization
C	0034198	biological_process	cellular response to amino acid starvation
C	0038202	biological_process	TORC1 signaling
C	0042149	biological_process	cellular response to glucose starvation
C	0042802	molecular_function	identical protein binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0045202	cellular_component	synapse
C	0045664	biological_process	regulation of neuron differentiation
C	0045947	biological_process	negative regulation of translational initiation
C	0045948	biological_process	positive regulation of translational initiation
C	0048167	biological_process	regulation of synaptic plasticity
C	0050821	biological_process	protein stabilization
C	0050868	biological_process	negative regulation of T cell activation
C	0050870	biological_process	positive regulation of T cell activation
C	0061462	biological_process	protein localization to lysosome
C	0070062	cellular_component	extracellular exosome
C	0085020	biological_process	protein K6-linked ubiquitination
C	0098793	cellular_component	presynapse
C	0140031	molecular_function	phosphorylation-dependent protein binding
C	0140311	molecular_function	protein sequestering activity
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1904263	biological_process	positive regulation of TORC1 signaling
D	0002181	biological_process	cytoplasmic translation
D	0002841	biological_process	negative regulation of T cell mediated immune response to tumor cell
D	0002842	biological_process	positive regulation of T cell mediated immune response to tumor cell
D	0003723	molecular_function	RNA binding
D	0005080	molecular_function	protein kinase C binding
D	0005159	molecular_function	insulin-like growth factor receptor binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005829	cellular_component	cytosol
D	0005925	cellular_component	focal adhesion
D	0006469	biological_process	negative regulation of protein kinase activity
D	0006605	biological_process	protein targeting
D	0007165	biological_process	signal transduction
D	0008104	biological_process	protein localization
D	0008426	molecular_function	protein kinase C inhibitor activity
D	0009966	biological_process	regulation of signal transduction
D	0016020	cellular_component	membrane
D	0019904	molecular_function	protein domain specific binding
D	0022409	biological_process	positive regulation of cell-cell adhesion
D	0030971	molecular_function	receptor tyrosine kinase binding
D	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D	0031669	biological_process	cellular response to nutrient levels
D	0031982	cellular_component	vesicle
D	0032869	biological_process	cellular response to insulin stimulus
D	0032880	biological_process	regulation of protein localization
D	0034198	biological_process	cellular response to amino acid starvation
D	0038202	biological_process	TORC1 signaling
D	0042149	biological_process	cellular response to glucose starvation
D	0042802	molecular_function	identical protein binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0045202	cellular_component	synapse
D	0045664	biological_process	regulation of neuron differentiation
D	0045947	biological_process	negative regulation of translational initiation
D	0045948	biological_process	positive regulation of translational initiation
D	0048167	biological_process	regulation of synaptic plasticity
D	0050821	biological_process	protein stabilization
D	0050868	biological_process	negative regulation of T cell activation
D	0050870	biological_process	positive regulation of T cell activation
D	0061462	biological_process	protein localization to lysosome
D	0070062	cellular_component	extracellular exosome
D	0085020	biological_process	protein K6-linked ubiquitination
D	0098793	cellular_component	presynapse
D	0140031	molecular_function	phosphorylation-dependent protein binding
D	0140311	molecular_function	protein sequestering activity
D	1904262	biological_process	negative regulation of TORC1 signaling
D	1904263	biological_process	positive regulation of TORC1 signaling
E	0002181	biological_process	cytoplasmic translation
E	0002841	biological_process	negative regulation of T cell mediated immune response to tumor cell
E	0002842	biological_process	positive regulation of T cell mediated immune response to tumor cell
E	0003723	molecular_function	RNA binding
E	0005080	molecular_function	protein kinase C binding
E	0005159	molecular_function	insulin-like growth factor receptor binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005829	cellular_component	cytosol
E	0005925	cellular_component	focal adhesion
E	0006469	biological_process	negative regulation of protein kinase activity
E	0006605	biological_process	protein targeting
E	0007165	biological_process	signal transduction
E	0008104	biological_process	protein localization
E	0008426	molecular_function	protein kinase C inhibitor activity
E	0009966	biological_process	regulation of signal transduction
E	0016020	cellular_component	membrane
E	0019904	molecular_function	protein domain specific binding
E	0022409	biological_process	positive regulation of cell-cell adhesion
E	0030971	molecular_function	receptor tyrosine kinase binding
E	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
E	0031669	biological_process	cellular response to nutrient levels
E	0031982	cellular_component	vesicle
E	0032869	biological_process	cellular response to insulin stimulus
E	0032880	biological_process	regulation of protein localization
E	0034198	biological_process	cellular response to amino acid starvation
E	0038202	biological_process	TORC1 signaling
E	0042149	biological_process	cellular response to glucose starvation
E	0042802	molecular_function	identical protein binding
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0045202	cellular_component	synapse
E	0045664	biological_process	regulation of neuron differentiation
E	0045947	biological_process	negative regulation of translational initiation
E	0045948	biological_process	positive regulation of translational initiation
E	0048167	biological_process	regulation of synaptic plasticity
E	0050821	biological_process	protein stabilization
E	0050868	biological_process	negative regulation of T cell activation
E	0050870	biological_process	positive regulation of T cell activation
E	0061462	biological_process	protein localization to lysosome
E	0070062	cellular_component	extracellular exosome
E	0085020	biological_process	protein K6-linked ubiquitination
E	0098793	cellular_component	presynapse
E	0140031	molecular_function	phosphorylation-dependent protein binding
E	0140311	molecular_function	protein sequestering activity
E	1904262	biological_process	negative regulation of TORC1 signaling
E	1904263	biological_process	positive regulation of TORC1 signaling
F	0002181	biological_process	cytoplasmic translation
F	0002841	biological_process	negative regulation of T cell mediated immune response to tumor cell
F	0002842	biological_process	positive regulation of T cell mediated immune response to tumor cell
F	0003723	molecular_function	RNA binding
F	0005080	molecular_function	protein kinase C binding
F	0005159	molecular_function	insulin-like growth factor receptor binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005829	cellular_component	cytosol
F	0005925	cellular_component	focal adhesion
F	0006469	biological_process	negative regulation of protein kinase activity
F	0006605	biological_process	protein targeting
F	0007165	biological_process	signal transduction
F	0008104	biological_process	protein localization
F	0008426	molecular_function	protein kinase C inhibitor activity
F	0009966	biological_process	regulation of signal transduction
F	0016020	cellular_component	membrane
F	0019904	molecular_function	protein domain specific binding
F	0022409	biological_process	positive regulation of cell-cell adhesion
F	0030971	molecular_function	receptor tyrosine kinase binding
F	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
F	0031669	biological_process	cellular response to nutrient levels
F	0031982	cellular_component	vesicle
F	0032869	biological_process	cellular response to insulin stimulus
F	0032880	biological_process	regulation of protein localization
F	0034198	biological_process	cellular response to amino acid starvation
F	0038202	biological_process	TORC1 signaling
F	0042149	biological_process	cellular response to glucose starvation
F	0042802	molecular_function	identical protein binding
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0045202	cellular_component	synapse
F	0045664	biological_process	regulation of neuron differentiation
F	0045947	biological_process	negative regulation of translational initiation
F	0045948	biological_process	positive regulation of translational initiation
F	0048167	biological_process	regulation of synaptic plasticity
F	0050821	biological_process	protein stabilization
F	0050868	biological_process	negative regulation of T cell activation
F	0050870	biological_process	positive regulation of T cell activation
F	0061462	biological_process	protein localization to lysosome
F	0070062	cellular_component	extracellular exosome
F	0085020	biological_process	protein K6-linked ubiquitination
F	0098793	cellular_component	presynapse
F	0140031	molecular_function	phosphorylation-dependent protein binding
F	0140311	molecular_function	protein sequestering activity
F	1904262	biological_process	negative regulation of TORC1 signaling
F	1904263	biological_process	positive regulation of TORC1 signaling
G	0002181	biological_process	cytoplasmic translation
G	0002841	biological_process	negative regulation of T cell mediated immune response to tumor cell
G	0002842	biological_process	positive regulation of T cell mediated immune response to tumor cell
G	0003723	molecular_function	RNA binding
G	0005080	molecular_function	protein kinase C binding
G	0005159	molecular_function	insulin-like growth factor receptor binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005829	cellular_component	cytosol
G	0005925	cellular_component	focal adhesion
G	0006469	biological_process	negative regulation of protein kinase activity
G	0006605	biological_process	protein targeting
G	0007165	biological_process	signal transduction
G	0008104	biological_process	protein localization
G	0008426	molecular_function	protein kinase C inhibitor activity
G	0009966	biological_process	regulation of signal transduction
G	0016020	cellular_component	membrane
G	0019904	molecular_function	protein domain specific binding
G	0022409	biological_process	positive regulation of cell-cell adhesion
G	0030971	molecular_function	receptor tyrosine kinase binding
G	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
G	0031669	biological_process	cellular response to nutrient levels
G	0031982	cellular_component	vesicle
G	0032869	biological_process	cellular response to insulin stimulus
G	0032880	biological_process	regulation of protein localization
G	0034198	biological_process	cellular response to amino acid starvation
G	0038202	biological_process	TORC1 signaling
G	0042149	biological_process	cellular response to glucose starvation
G	0042802	molecular_function	identical protein binding
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0045202	cellular_component	synapse
G	0045664	biological_process	regulation of neuron differentiation
G	0045947	biological_process	negative regulation of translational initiation
G	0045948	biological_process	positive regulation of translational initiation
G	0048167	biological_process	regulation of synaptic plasticity
G	0050821	biological_process	protein stabilization
G	0050868	biological_process	negative regulation of T cell activation
G	0050870	biological_process	positive regulation of T cell activation
G	0061462	biological_process	protein localization to lysosome
G	0070062	cellular_component	extracellular exosome
G	0085020	biological_process	protein K6-linked ubiquitination
G	0098793	cellular_component	presynapse
G	0140031	molecular_function	phosphorylation-dependent protein binding
G	0140311	molecular_function	protein sequestering activity
G	1904262	biological_process	negative regulation of TORC1 signaling
G	1904263	biological_process	positive regulation of TORC1 signaling
H	0002181	biological_process	cytoplasmic translation
H	0002841	biological_process	negative regulation of T cell mediated immune response to tumor cell
H	0002842	biological_process	positive regulation of T cell mediated immune response to tumor cell
H	0003723	molecular_function	RNA binding
H	0005080	molecular_function	protein kinase C binding
H	0005159	molecular_function	insulin-like growth factor receptor binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0005829	cellular_component	cytosol
H	0005925	cellular_component	focal adhesion
H	0006469	biological_process	negative regulation of protein kinase activity
H	0006605	biological_process	protein targeting
H	0007165	biological_process	signal transduction
H	0008104	biological_process	protein localization
H	0008426	molecular_function	protein kinase C inhibitor activity
H	0009966	biological_process	regulation of signal transduction
H	0016020	cellular_component	membrane
H	0019904	molecular_function	protein domain specific binding
H	0022409	biological_process	positive regulation of cell-cell adhesion
H	0030971	molecular_function	receptor tyrosine kinase binding
H	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
H	0031669	biological_process	cellular response to nutrient levels
H	0031982	cellular_component	vesicle
H	0032869	biological_process	cellular response to insulin stimulus
H	0032880	biological_process	regulation of protein localization
H	0034198	biological_process	cellular response to amino acid starvation
H	0038202	biological_process	TORC1 signaling
H	0042149	biological_process	cellular response to glucose starvation
H	0042802	molecular_function	identical protein binding
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0045202	cellular_component	synapse
H	0045664	biological_process	regulation of neuron differentiation
H	0045947	biological_process	negative regulation of translational initiation
H	0045948	biological_process	positive regulation of translational initiation
H	0048167	biological_process	regulation of synaptic plasticity
H	0050821	biological_process	protein stabilization
H	0050868	biological_process	negative regulation of T cell activation
H	0050870	biological_process	positive regulation of T cell activation
H	0061462	biological_process	protein localization to lysosome
H	0070062	cellular_component	extracellular exosome
H	0085020	biological_process	protein K6-linked ubiquitination
H	0098793	cellular_component	presynapse
H	0140031	molecular_function	phosphorylation-dependent protein binding
H	0140311	molecular_function	protein sequestering activity
H	1904262	biological_process	negative regulation of TORC1 signaling
H	1904263	biological_process	positive regulation of TORC1 signaling

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG42-VAL52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Site: {"description":"Interaction with phosphoserine on interacting protein","evidences":[{"source":"PubMed","id":"17085597","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P61983","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Boldt K.","von Kriegsheim A.F.","Zebisch A.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P61983","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	Modified residue: {"description":"N-acetylvaline; partial","evidences":[{"source":"PubMed","id":"14534293","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Boldt K.","von Kriegsheim A.F.","Zebisch A.","Kolch W."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Claeys D."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	164
Details	Region: {"description":"Required for interaction with SPATA18/MIEAP (isoform 2) but dispensable for binding to SPATA18/MIEAP (isoform 1)","evidences":[{"source":"PubMed","id":"22532927","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---