6GK7

Crystal structure of anti-tau antibody dmCBTAU-27.1, double mutant (S31Y, T100I) of CBTAU-27.1, in complex with Tau peptide A8119B (residues 299-318)

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue CL H 301

Chain	Residue
H	HIS173
L	ASP173

---

site_id	AC2
Number of Residues	2
Details	binding site for residue CL H 302

Chain	Residue
H	GLN201
L	VAL169

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR198-HIS204
H	TYR203-HIS209

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Not glycated => ECO:0000269|PubMed:9326300

Chain	Residue	Details
A	LYS311
A	LYS317

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	LYS311
A	LYS317

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau => ECO:0000269|PubMed:16443603

Chain	Residue	Details
A	LYS311

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	LYS317

---