Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6GHV

Structure of a DC-SIGN CRD in complex with high affinity glycomimetic.

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue EZ8 A 1001

Chain	Residue
A	PHE313
A	ASP367
A	LYS368
A	CA1002
A	HOH1108
A	HOH1113
D	ASN272
D	ARG309
D	SER310
D	ASN311
D	ARG312
A	GLU347
D	THR314
D	CL501
A	ASN349
A	GLY352
A	GLU354
A	GLU358
A	SER360
A	ASN365
A	ASP366

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 1002

Chain	Residue
A	GLU347
A	ASN349
A	GLU354
A	ASN365
A	ASP366
A	EZ81001

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 1003

Chain	Residue
A	ASP320
A	GLU324
A	ASN350
A	GLU354
A	ASP355
A	HOH1129

site_id	AC4
Number of Residues	4
Details	binding site for residue CA A 1004

Chain	Residue
A	ASP355
A	HOH1102
A	HOH1118
A	HOH1139

site_id	AC5
Number of Residues	2
Details	binding site for residue CL A 1005

Chain	Residue
A	ASN272
A	SER273

site_id	AC6
Number of Residues	1
Details	binding site for residue CL A 1006

Chain	Residue
A	ARG309

site_id	AC7
Number of Residues	2
Details	binding site for residue CL A 1007

Chain	Residue
A	GLN264
B	EZ81001

site_id	AC8
Number of Residues	29
Details	binding site for residue EZ8 B 1001

Chain	Residue
A	GLN264
A	GLY265
A	CL1007
B	PHE313
B	GLU347
B	ASN349
B	VAL351
B	GLY352
B	GLU354
B	GLU358
B	SER360
B	ASN365
B	ASP366
B	ASP367
B	LYS368
B	CA1002
B	HOH1105
B	HOH1111
B	HOH1116
B	HOH1151
C	ASN272
C	GLN306
C	ARG309
C	SER310
C	ASN311
C	ARG312
C	THR314
C	PHE374
C	HOH1139

site_id	AC9
Number of Residues	6
Details	binding site for residue CA B 1002

Chain	Residue
B	GLU347
B	ASN349
B	GLU354
B	ASN365
B	ASP366
B	EZ81001

site_id	AD1
Number of Residues	6
Details	binding site for residue CA B 1003

Chain	Residue
B	ASP320
B	GLU324
B	ASN350
B	GLU354
B	ASP355
B	HOH1133

site_id	AD2
Number of Residues	6
Details	binding site for residue CA B 1004

Chain	Residue
B	ASP355
B	HOH1108
B	HOH1126
B	HOH1148
B	HOH1155
B	HOH1212

site_id	AD3
Number of Residues	1
Details	binding site for residue CL B 1005

Chain	Residue
B	SER273

site_id	AD4
Number of Residues	2
Details	binding site for residue CL B 1006

Chain	Residue
B	GLN264
F	EZ8502

site_id	AD5
Number of Residues	28
Details	binding site for residue EZ8 C 1001

Chain	Residue
B	PHE374
C	PHE313
C	GLU347
C	ASN349
C	VAL351
C	GLY352
C	GLU354
C	GLU358
C	SER360
C	ASN365
C	ASP366
C	ASP367
C	LYS368
C	CA1002
C	HOH1105
C	HOH1111
C	HOH1124
E	GLN264
E	GLY265
E	GLU298
E	CL502
B	ASN272
B	GLN306
B	ARG309
B	SER310
B	ASN311
B	ARG312
B	THR314

site_id	AD6
Number of Residues	6
Details	binding site for residue CA C 1002

Chain	Residue
C	GLU347
C	ASN349
C	GLU354
C	ASN365
C	ASP366
C	EZ81001

site_id	AD7
Number of Residues	6
Details	binding site for residue CA C 1003

Chain	Residue
C	ASP320
C	GLU324
C	ASN350
C	GLU354
C	ASP355
C	HOH1121

site_id	AD8
Number of Residues	6
Details	binding site for residue CA C 1004

Chain	Residue
C	ASP355
C	HOH1112
C	HOH1126
C	HOH1128
C	HOH1130
C	HOH1221

site_id	AD9
Number of Residues	2
Details	binding site for residue CL C 1005

Chain	Residue
C	ASN272
C	SER273

site_id	AE1
Number of Residues	2
Details	binding site for residue CL C 1006

Chain	Residue
C	GLN264
D	EZ8502

site_id	AE2
Number of Residues	1
Details	binding site for residue CL D 501

Chain	Residue
A	EZ81001

site_id	AE3
Number of Residues	27
Details	binding site for residue EZ8 D 502

Chain	Residue
A	SER271
A	ASN272
A	ARG309
A	SER310
A	ASN311
A	ARG312
A	THR314
A	PHE374
C	PHE263
C	GLN264
C	GLY265
C	GLU298
C	CL1006
D	PHE313
D	GLU347
D	ASN349
D	VAL351
D	GLU354
D	GLU358
D	SER360
D	ASN365
D	ASP366
D	ASP367
D	LYS368
D	CA503
D	HOH601
D	HOH628

site_id	AE4
Number of Residues	6
Details	binding site for residue CA D 503

Chain	Residue
D	GLU347
D	ASN349
D	GLU354
D	ASN365
D	ASP366
D	EZ8502

site_id	AE5
Number of Residues	6
Details	binding site for residue CA D 504

Chain	Residue
D	ASP320
D	GLU324
D	ASN350
D	GLU354
D	ASP355
D	HOH623

site_id	AE6
Number of Residues	6
Details	binding site for residue CA D 505

Chain	Residue
D	ASP355
D	HOH610
D	HOH617
D	HOH622
D	HOH649
D	HOH697

site_id	AE7
Number of Residues	2
Details	binding site for residue CL D 506

Chain	Residue
D	ASN272
D	SER273

site_id	AE8
Number of Residues	2
Details	binding site for residue CL E 501

Chain	Residue
B	ARG309
E	ARG309

site_id	AE9
Number of Residues	2
Details	binding site for residue CL E 502

Chain	Residue
C	EZ81001
E	GLN264

site_id	AF1
Number of Residues	25
Details	binding site for residue EZ8 E 503

Chain	Residue
E	PHE313
E	GLU347
E	ASN349
E	VAL351
E	GLY352
E	GLU354
E	GLU358
E	SER360
E	ASN365
E	ASP366
E	ASP367
E	LYS368
E	CA504
E	HOH615
E	HOH620
E	HOH648
E	HOH650
F	ASN272
F	ARG309
F	SER310
F	ASN311
F	ARG312
F	THR314
F	PHE374
F	CL501

site_id	AF2
Number of Residues	6
Details	binding site for residue CA E 504

Chain	Residue
E	GLU347
E	ASN349
E	GLU354
E	ASN365
E	ASP366
E	EZ8503

site_id	AF3
Number of Residues	6
Details	binding site for residue CA E 505

Chain	Residue
E	ASP320
E	GLU324
E	ASN350
E	GLU354
E	ASP355
E	HOH638

site_id	AF4
Number of Residues	7
Details	binding site for residue CA E 506

Chain	Residue
E	GLU324
E	ASP355
E	HOH608
E	HOH613
E	HOH622
E	HOH629
E	HOH707

site_id	AF5
Number of Residues	2
Details	binding site for residue CL E 507

Chain	Residue
E	ASN272
E	SER273

site_id	AF6
Number of Residues	1
Details	binding site for residue CL F 501

Chain	Residue
E	EZ8503

site_id	AF7
Number of Residues	26
Details	binding site for residue EZ8 F 502

Chain	Residue
B	GLN264
B	GLY265
B	CL1006
E	ASN272
E	ARG309
E	SER310
E	ASN311
E	ARG312
E	THR314
E	PHE374
F	PHE313
F	GLU347
F	ASN349
F	VAL351
F	GLY352
F	GLU354
F	GLU358
F	SER360
F	ASN365
F	ASP366
F	ASP367
F	LYS368
F	CA503
F	HOH602
F	HOH615
F	HOH622

site_id	AF8
Number of Residues	6
Details	binding site for residue CA F 503

Chain	Residue
F	GLU347
F	ASN349
F	GLU354
F	ASN365
F	ASP366
F	EZ8502

site_id	AF9
Number of Residues	6
Details	binding site for residue CA F 504

Chain	Residue
F	ASP320
F	GLU324
F	ASN350
F	GLU354
F	ASP355
F	HOH618

site_id	AG1
Number of Residues	4
Details	binding site for residue CA F 505

Chain	Residue
F	ASP355
F	HOH604
F	HOH605
F	HOH693

site_id	AG2
Number of Residues	3
Details	binding site for residue CL F 506

Chain	Residue
F	SER271
F	ASN272
F	SER273

Functional Information from PROSITE/UniProt

site_id	PS00615
Number of Residues	22
Details	C_TYPE_LECTIN_1 C-type lectin domain signature. CAefsgng......WNDDKCnlakf.WIC

Chain	Residue	Details
A	CYS356-CYS377

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	690
Details	Domain: {"description":"C-type lectin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00040","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)