6G7O
Crystal structure of human alkaline ceramidase 3 (ACER3) at 2.7 Angstrom resolution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000139 | cellular_component | Golgi membrane |
A | 0005506 | molecular_function | iron ion binding |
A | 0005509 | molecular_function | calcium ion binding |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0005794 | cellular_component | Golgi apparatus |
A | 0006665 | biological_process | sphingolipid metabolic process |
A | 0006672 | biological_process | ceramide metabolic process |
A | 0006954 | biological_process | inflammatory response |
A | 0008270 | molecular_function | zinc ion binding |
A | 0008284 | biological_process | positive regulation of cell population proliferation |
A | 0009055 | molecular_function | electron transfer activity |
A | 0016020 | cellular_component | membrane |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
A | 0017040 | molecular_function | N-acylsphingosine amidohydrolase activity |
A | 0020037 | molecular_function | heme binding |
A | 0022900 | biological_process | electron transport chain |
A | 0042552 | biological_process | myelination |
A | 0042597 | cellular_component | periplasmic space |
A | 0043067 | biological_process | regulation of programmed cell death |
A | 0046512 | biological_process | sphingosine biosynthetic process |
A | 0046514 | biological_process | ceramide catabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0070774 | molecular_function | phytoceramidase activity |
A | 0071602 | biological_process | phytosphingosine biosynthetic process |
A | 0071633 | molecular_function | dihydroceramidase activity |
A | 0102121 | molecular_function | ceramidase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue ZN A 401 |
Chain | Residue |
A | HIS81 |
A | HIS217 |
A | HIS221 |
A | OLB411 |
A | HOH505 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 402 |
Chain | Residue |
A | MG414 |
A | GLU60 |
A | LYS61 |
A | ARG62 |
A | SO4403 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue SO4 A 403 |
Chain | Residue |
A | LYS61 |
A | LYS259 |
A | LYS339 |
A | ARG342 |
A | SO4402 |
A | HOH515 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 404 |
Chain | Residue |
A | PHE111 |
A | ARG159 |
A | TYR162 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue SO4 A 405 |
Chain | Residue |
A | TYR119 |
A | ASN343 |
A | ALA344 |
A | LYS348 |
A | HOH527 |
A | HOH528 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue SO4 A 406 |
Chain | Residue |
A | LYS303 |
A | ARG306 |
A | HOH509 |
A | HOH514 |
A | HOH525 |
A | HOH532 |
site_id | AC7 |
Number of Residues | 7 |
Details | binding site for residue SO4 A 407 |
Chain | Residue |
A | ASP265 |
A | ASN266 |
A | ALA267 |
A | MG413 |
A | MG413 |
A | HOH516 |
A | HOH541 |
site_id | AC8 |
Number of Residues | 1 |
Details | binding site for residue NA A 408 |
Chain | Residue |
A | TRP219 |
site_id | AC9 |
Number of Residues | 2 |
Details | binding site for residue NA A 409 |
Chain | Residue |
A | ASP246 |
A | HOH526 |
site_id | AD1 |
Number of Residues | 2 |
Details | binding site for residue NA A 410 |
Chain | Residue |
A | THR14 |
A | ASP19 |
site_id | AD2 |
Number of Residues | 15 |
Details | binding site for residue OLB A 411 |
Chain | Residue |
A | ASP92 |
A | GLU93 |
A | MET96 |
A | SER99 |
A | PHE103 |
A | HIS145 |
A | TYR149 |
A | PHE182 |
A | PHE186 |
A | TRP189 |
A | TRP220 |
A | HIS221 |
A | THR224 |
A | SER228 |
A | ZN401 |
site_id | AD3 |
Number of Residues | 5 |
Details | binding site for residue CA A 412 |
Chain | Residue |
A | ASP19 |
A | TRP20 |
A | GLU22 |
A | ASN24 |
A | GLU33 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residue MG A 413 |
Chain | Residue |
A | SO4407 |
A | SO4407 |
A | HOH509 |
A | HOH509 |
A | HOH516 |
A | HOH516 |
site_id | AD5 |
Number of Residues | 4 |
Details | binding site for residue MG A 414 |
Chain | Residue |
A | GLU60 |
A | LYS114 |
A | ASN115 |
A | SO4402 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 141 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:30575723 |
Chain | Residue | Details |
A | PHE34-VAL55 | |
A | ARG62-MET82 | |
A | MET88-PHE108 | |
A | TYR119-VAL139 | |
A | PRO142-TYR162 | |
A | LEU174-ILE194 | |
A | PHE216-LEU236 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:30575723 |
Chain | Residue | Details |
A | ARG56-LYS61 | |
A | GLU109-ASN118 | |
A | ILE163-GLY173 |
site_id | SWS_FT_FI3 |
Number of Residues | 25 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30575723 |
Chain | Residue | Details |
A | THR83-GLU87 | |
A | LYS140-GLU141 | |
A | PHE195-GLN215 |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30575723, ECO:0007744|PDB:6G7O |
Chain | Residue | Details |
A | ASP19 | |
A | TRP20 | |
A | GLU22 | |
A | ASN24 | |
A | GLU33 | |
A | HIS81 | |
A | HIS217 | |
A | HIS221 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: axial binding residue |
Chain | Residue | Details |
A | TRP251 | |
A | ILE346 |