6G7O
Crystal structure of human alkaline ceramidase 3 (ACER3) at 2.7 Angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006665 | biological_process | sphingolipid metabolic process |
| A | 0006672 | biological_process | ceramide metabolic process |
| A | 0006954 | biological_process | inflammatory response |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017040 | molecular_function | N-acylsphingosine amidohydrolase activity |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0042552 | biological_process | myelination |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0043067 | biological_process | regulation of programmed cell death |
| A | 0046512 | biological_process | sphingosine biosynthetic process |
| A | 0046514 | biological_process | ceramide catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0071602 | biological_process | phytosphingosine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | HIS81 |
| A | HIS217 |
| A | HIS221 |
| A | OLB411 |
| A | HOH505 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | MG414 |
| A | GLU60 |
| A | LYS61 |
| A | ARG62 |
| A | SO4403 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | LYS61 |
| A | LYS259 |
| A | LYS339 |
| A | ARG342 |
| A | SO4402 |
| A | HOH515 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | PHE111 |
| A | ARG159 |
| A | TYR162 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | TYR119 |
| A | ASN343 |
| A | ALA344 |
| A | LYS348 |
| A | HOH527 |
| A | HOH528 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 406 |
| Chain | Residue |
| A | LYS303 |
| A | ARG306 |
| A | HOH509 |
| A | HOH514 |
| A | HOH525 |
| A | HOH532 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 407 |
| Chain | Residue |
| A | ASP265 |
| A | ASN266 |
| A | ALA267 |
| A | MG413 |
| A | MG413 |
| A | HOH516 |
| A | HOH541 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue NA A 408 |
| Chain | Residue |
| A | TRP219 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue NA A 409 |
| Chain | Residue |
| A | ASP246 |
| A | HOH526 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue NA A 410 |
| Chain | Residue |
| A | THR14 |
| A | ASP19 |
| site_id | AD2 |
| Number of Residues | 15 |
| Details | binding site for residue OLB A 411 |
| Chain | Residue |
| A | ASP92 |
| A | GLU93 |
| A | MET96 |
| A | SER99 |
| A | PHE103 |
| A | HIS145 |
| A | TYR149 |
| A | PHE182 |
| A | PHE186 |
| A | TRP189 |
| A | TRP220 |
| A | HIS221 |
| A | THR224 |
| A | SER228 |
| A | ZN401 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 412 |
| Chain | Residue |
| A | ASP19 |
| A | TRP20 |
| A | GLU22 |
| A | ASN24 |
| A | GLU33 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 413 |
| Chain | Residue |
| A | SO4407 |
| A | SO4407 |
| A | HOH509 |
| A | HOH509 |
| A | HOH516 |
| A | HOH516 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 414 |
| Chain | Residue |
| A | GLU60 |
| A | LYS114 |
| A | ASN115 |
| A | SO4402 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 13 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 141 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30575723","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"30575723","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 25 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30575723","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30575723","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6G7O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
