6G6L
The crystal structures of Human MYC:MAX bHLHZip complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0046983 | molecular_function | protein dimerization activity |
| B | 0046983 | molecular_function | protein dimerization activity |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0046983 | molecular_function | protein dimerization activity |
| D | 0046983 | molecular_function | protein dimerization activity |
| E | 0003700 | molecular_function | DNA-binding transcription factor activity |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0046983 | molecular_function | protein dimerization activity |
| F | 0046983 | molecular_function | protein dimerization activity |
| G | 0003700 | molecular_function | DNA-binding transcription factor activity |
| G | 0006355 | biological_process | regulation of DNA-templated transcription |
| G | 0046983 | molecular_function | protein dimerization activity |
| H | 0046983 | molecular_function | protein dimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1001 |
| Chain | Residue |
| A | LYS939 |
| A | HOH1109 |
| B | ARG214 |
| G | LYS936 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1002 |
| Chain | Residue |
| A | GLN912 |
| A | ASN915 |
| A | ARG919 |
| A | HOH1101 |
| D | HIS258 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 301 |
| Chain | Residue |
| A | ARG913 |
| B | SER238 |
| B | ARG239 |
| B | HOH402 |
| B | HOH406 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 C 1001 |
| Chain | Residue |
| B | ARG254 |
| B | HIS258 |
| C | GLN912 |
| C | ASN915 |
| C | ARG919 |
| C | HOH1103 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 301 |
| Chain | Residue |
| D | SER238 |
| D | ARG239 |
| D | HOH404 |
| D | HOH420 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 D 302 |
| Chain | Residue |
| C | PRO938 |
| C | LYS939 |
| D | ARG214 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 E 1001 |
| Chain | Residue |
| E | PRO938 |
| E | LYS939 |
| F | ARG214 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 F 302 |
| Chain | Residue |
| E | ARG913 |
| E | HOH1109 |
| F | SER238 |
| F | ARG239 |
| F | HOH402 |
| F | HOH421 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 G 1001 |
| Chain | Residue |
| F | ARG254 |
| F | HIS258 |
| G | ASN915 |
| G | ARG919 |
| G | HOH1105 |
| G | HOH1112 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 G 1002 |
| Chain | Residue |
| A | LYS936 |
| G | PRO938 |
| G | LYS939 |
| G | HOH1110 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 H 301 |
| Chain | Residue |
| G | ARG913 |
| H | SER238 |
| H | ARG239 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 H 302 |
| Chain | Residue |
| E | ASN915 |
| E | ARG919 |
| H | ARG254 |
| H | HIS258 |
| H | HOH401 |
| site_id | AD4 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide SO4 B 302 and ARG C 919 |
| Chain | Residue |
| A | ASP926 |
| A | GLU932 |
| B | GLN251 |
| B | ARG254 |
| B | ARG254 |
| B | ARG255 |
| B | HOH401 |
| B | HOH429 |
| C | ASN915 |
| C | GLU916 |
| C | GLU916 |
| C | LEU917 |
| C | LYS918 |
| C | SER920 |
| C | PHE921 |
| C | PHE922 |
| C | ALA923 |
| C | SO41001 |
| C | HOH1103 |
| site_id | AD5 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide SO4 F 301 and ARG G 919 |
| Chain | Residue |
| E | ASP926 |
| E | GLU932 |
| F | ARG254 |
| F | ARG254 |
| G | ASN915 |
| G | GLU916 |
| G | GLU916 |
| G | LEU917 |
| G | LYS918 |
| G | SER920 |
| G | PHE921 |
| G | PHE922 |
| G | ALA923 |
| G | SO41001 |
| G | HOH1112 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 152 |
| Details | Region: {"description":"Helix-loop-helix motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00981","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 168 |
| Details | Region: {"description":"Leucine-zipper"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine; by PCAF","evidences":[{"source":"PubMed","id":"16126174","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17217336","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
