6G6K
The crystal structures of Human MYC:MAX bHLHZip complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0046983 | molecular_function | protein dimerization activity |
| B | 0046983 | molecular_function | protein dimerization activity |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0046983 | molecular_function | protein dimerization activity |
| D | 0046983 | molecular_function | protein dimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 1001 |
| Chain | Residue |
| A | LYS939 |
| B | ARG239 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 1001 |
| Chain | Residue |
| C | LYS939 |
| D | ARG239 |
| D | HOH357 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 104 |
| Details | Domain: {"description":"bHLH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00981","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 26 |
| Details | Region: {"description":"Basic motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00981","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 76 |
| Details | Region: {"description":"Helix-loop-helix motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00981","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 42 |
| Details | Region: {"description":"Leucine-zipper"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | Motif: {"description":"UBR5-degron","evidences":[{"source":"PubMed","id":"37478862","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine; by PCAF","evidences":[{"source":"PubMed","id":"16126174","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17217336","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
