6G2H

Filament of acetyl-CoA carboxylase and BRCT domains of BRCA1 (ACC-BRCT) core at 4.6 A resolution

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001650	cellular_component	fibrillar center
A	0001894	biological_process	tissue homeostasis
A	0003824	molecular_function	catalytic activity
A	0003989	molecular_function	acetyl-CoA carboxylase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006084	biological_process	acetyl-CoA metabolic process
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0008152	biological_process	metabolic process
A	0008610	biological_process	lipid biosynthetic process
A	0015629	cellular_component	actin cytoskeleton
A	0016874	molecular_function	ligase activity
A	0019538	biological_process	protein metabolic process
A	0042802	molecular_function	identical protein binding
A	0044281	biological_process	small molecule metabolic process
A	0046872	molecular_function	metal ion binding
A	0046949	biological_process	fatty-acyl-CoA biosynthetic process
A	0051289	biological_process	protein homotetramerization
A	0055088	biological_process	lipid homeostasis
A	0071380	biological_process	cellular response to prostaglandin E stimulus
A	2001295	biological_process	malonyl-CoA biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0001650	cellular_component	fibrillar center
B	0001894	biological_process	tissue homeostasis
B	0003824	molecular_function	catalytic activity
B	0003989	molecular_function	acetyl-CoA carboxylase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006084	biological_process	acetyl-CoA metabolic process
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0008152	biological_process	metabolic process
B	0008610	biological_process	lipid biosynthetic process
B	0015629	cellular_component	actin cytoskeleton
B	0016874	molecular_function	ligase activity
B	0019538	biological_process	protein metabolic process
B	0042802	molecular_function	identical protein binding
B	0044281	biological_process	small molecule metabolic process
B	0046872	molecular_function	metal ion binding
B	0046949	biological_process	fatty-acyl-CoA biosynthetic process
B	0051289	biological_process	protein homotetramerization
B	0055088	biological_process	lipid homeostasis
B	0071380	biological_process	cellular response to prostaglandin E stimulus
B	2001295	biological_process	malonyl-CoA biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0001650	cellular_component	fibrillar center
C	0001894	biological_process	tissue homeostasis
C	0003824	molecular_function	catalytic activity
C	0003989	molecular_function	acetyl-CoA carboxylase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006084	biological_process	acetyl-CoA metabolic process
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0008152	biological_process	metabolic process
C	0008610	biological_process	lipid biosynthetic process
C	0015629	cellular_component	actin cytoskeleton
C	0016874	molecular_function	ligase activity
C	0019538	biological_process	protein metabolic process
C	0042802	molecular_function	identical protein binding
C	0044281	biological_process	small molecule metabolic process
C	0046872	molecular_function	metal ion binding
C	0046949	biological_process	fatty-acyl-CoA biosynthetic process
C	0051289	biological_process	protein homotetramerization
C	0055088	biological_process	lipid homeostasis
C	0071380	biological_process	cellular response to prostaglandin E stimulus
C	2001295	biological_process	malonyl-CoA biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0001650	cellular_component	fibrillar center
D	0001894	biological_process	tissue homeostasis
D	0003824	molecular_function	catalytic activity
D	0003989	molecular_function	acetyl-CoA carboxylase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006084	biological_process	acetyl-CoA metabolic process
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0008152	biological_process	metabolic process
D	0008610	biological_process	lipid biosynthetic process
D	0015629	cellular_component	actin cytoskeleton
D	0016874	molecular_function	ligase activity
D	0019538	biological_process	protein metabolic process
D	0042802	molecular_function	identical protein binding
D	0044281	biological_process	small molecule metabolic process
D	0046872	molecular_function	metal ion binding
D	0046949	biological_process	fatty-acyl-CoA biosynthetic process
D	0051289	biological_process	protein homotetramerization
D	0055088	biological_process	lipid homeostasis
D	0071380	biological_process	cellular response to prostaglandin E stimulus
D	2001295	biological_process	malonyl-CoA biosynthetic process
E	0000166	molecular_function	nucleotide binding
E	0001650	cellular_component	fibrillar center
E	0001894	biological_process	tissue homeostasis
E	0003824	molecular_function	catalytic activity
E	0003989	molecular_function	acetyl-CoA carboxylase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0006084	biological_process	acetyl-CoA metabolic process
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0008152	biological_process	metabolic process
E	0008610	biological_process	lipid biosynthetic process
E	0015629	cellular_component	actin cytoskeleton
E	0016874	molecular_function	ligase activity
E	0019538	biological_process	protein metabolic process
E	0042802	molecular_function	identical protein binding
E	0044281	biological_process	small molecule metabolic process
E	0046872	molecular_function	metal ion binding
E	0046949	biological_process	fatty-acyl-CoA biosynthetic process
E	0051289	biological_process	protein homotetramerization
E	0055088	biological_process	lipid homeostasis
E	0071380	biological_process	cellular response to prostaglandin E stimulus
E	2001295	biological_process	malonyl-CoA biosynthetic process
F	0000166	molecular_function	nucleotide binding
F	0001650	cellular_component	fibrillar center
F	0001894	biological_process	tissue homeostasis
F	0003824	molecular_function	catalytic activity
F	0003989	molecular_function	acetyl-CoA carboxylase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0006084	biological_process	acetyl-CoA metabolic process
F	0006629	biological_process	lipid metabolic process
F	0006631	biological_process	fatty acid metabolic process
F	0006633	biological_process	fatty acid biosynthetic process
F	0008152	biological_process	metabolic process
F	0008610	biological_process	lipid biosynthetic process
F	0015629	cellular_component	actin cytoskeleton
F	0016874	molecular_function	ligase activity
F	0019538	biological_process	protein metabolic process
F	0042802	molecular_function	identical protein binding
F	0044281	biological_process	small molecule metabolic process
F	0046872	molecular_function	metal ion binding
F	0046949	biological_process	fatty-acyl-CoA biosynthetic process
F	0051289	biological_process	protein homotetramerization
F	0055088	biological_process	lipid homeostasis
F	0071380	biological_process	cellular response to prostaglandin E stimulus
F	2001295	biological_process	malonyl-CoA biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00188
Number of Residues	18
Details	BIOTIN Biotin-requiring enzymes attachment site. GQcYaeIeVMKMvmtLtA

Chain	Residue	Details
D	GLY776-ALA793

---

site_id	PS00866
Number of Residues	15
Details	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. YPVMIKASeggGGkG

Chain	Residue	Details
D	TYR306-GLY320

---

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. FLELNPRL

Chain	Residue	Details
D	PHE435-LEU442

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
D	ARG441
E	ARG441
C	ARG441
F	ARG441
B	ARG441
A	ARG441

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00409

Chain	Residue	Details
D	GLY315
E	GLY315
C	GLY315
F	GLY315
B	GLY315
A	GLY315

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00409, ECO:0000255|PROSITE-ProRule:PRU00969

Chain	Residue	Details
D	GLU424
F	GLU424
F	GLU437
F	ASN439
B	GLU424
B	GLU437
B	ASN439
A	GLU424
A	GLU437
A	ASN439
D	GLU437
D	ASN439
E	GLU424
E	GLU437
E	ASN439
C	GLU424
C	GLU437
C	ASN439

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
D	ARG1823
F	ARG1823
F	LYS2127
F	ARG2129
B	ARG1823
B	LYS2127
B	ARG2129
A	ARG1823
A	LYS2127
A	ARG2129
D	LYS2127
D	ARG2129
E	ARG1823
E	LYS2127
E	ARG2129
C	ARG1823
C	LYS2127
C	ARG2129

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: N-acetylmethionine => ECO:0000269|Ref.9, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231

Chain	Residue	Details
D	MET1
E	MET1
C	MET1
F	MET1
B	MET1
A	MET1

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER5
E	SER5
C	SER5
F	SER5
B	SER5
A	SER5

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231

Chain	Residue	Details
D	SER23
E	SER23
C	SER23
F	SER23
B	SER23
A	SER23

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	SER25
E	SER25
C	SER25
F	SER25
B	SER25
A	SER25

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	SER29
E	SER29
C	SER29
F	SER29
B	SER29
A	SER29

---

site_id	SWS_FT_FI10
Number of Residues	30
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P11497

Chain	Residue	Details
D	SER34
E	SER1216
C	SER34
C	SER50
C	SER78
C	SER1201
C	SER1216
F	SER34
F	SER50
F	SER78
F	SER1201
D	SER50
F	SER1216
B	SER34
B	SER50
B	SER78
B	SER1201
B	SER1216
A	SER34
A	SER50
A	SER78
A	SER1201
D	SER78
A	SER1216
D	SER1201
D	SER1216
E	SER34
E	SER50
E	SER78
E	SER1201

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
D	SER48
E	SER48
C	SER48
F	SER48
B	SER48
A	SER48

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983

Chain	Residue	Details
D	SER53
E	SER53
C	SER53
F	SER53
B	SER53
A	SER53

---

site_id	SWS_FT_FI13
Number of Residues	12
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q5SWU9

Chain	Residue	Details
D	THR58
B	THR1227
A	THR58
A	THR1227
D	THR1227
E	THR58
E	THR1227
C	THR58
C	THR1227
F	THR58
F	THR1227
B	THR58

---

site_id	SWS_FT_FI14
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:29899443, ECO:0000269|Ref.9, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER80
E	SER80
C	SER80
F	SER80
B	SER80
A	SER80

---

site_id	SWS_FT_FI15
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18220336

Chain	Residue	Details
D	SER488
E	SER488
C	SER488
F	SER488
B	SER488
A	SER488

---

site_id	SWS_FT_FI16
Number of Residues	12
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	THR610
B	THR2153
A	THR610
A	THR2153
D	THR2153
E	THR610
E	THR2153
C	THR610
C	THR2153
F	THR610
F	THR2153
B	THR610

---

site_id	SWS_FT_FI17
Number of Residues	6
Details	MOD_RES: N6-biotinyllysine => ECO:0000250|UniProtKB:P11497, ECO:0000255|PROSITE-ProRule:PRU01066

Chain	Residue	Details
D	LYS786
E	LYS786
C	LYS786
F	LYS786
B	LYS786
A	LYS786

---

site_id	SWS_FT_FI18
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER835
E	SER835
C	SER835
F	SER835
B	SER835
A	SER835

---

site_id	SWS_FT_FI19
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q5SWU9

Chain	Residue	Details
D	SER1218
B	SER1259
A	SER1218
A	SER1259
D	SER1259
E	SER1218
E	SER1259
C	SER1218
C	SER1259
F	SER1218
F	SER1259
B	SER1218

---

site_id	SWS_FT_FI20
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:16698035, ECO:0000269|PubMed:29899443

Chain	Residue	Details
D	SER1263
E	SER1263
C	SER1263
F	SER1263
B	SER1263
A	SER1263

---

site_id	SWS_FT_FI21
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	SER1273
E	SER1273
C	SER1273
F	SER1273
B	SER1273
A	SER1273

---

site_id	SWS_FT_FI22
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
D	LYS1334
E	LYS1334
C	LYS1334
F	LYS1334
B	LYS1334
A	LYS1334

---