6G2H

Filament of acetyl-CoA carboxylase and BRCT domains of BRCA1 (ACC-BRCT) core at 4.6 A resolution

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001650	cellular_component	fibrillar center
A	0001894	biological_process	tissue homeostasis
A	0003824	molecular_function	catalytic activity
A	0003989	molecular_function	acetyl-CoA carboxylase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006084	biological_process	acetyl-CoA metabolic process
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006637	biological_process	acyl-CoA metabolic process
A	0008610	biological_process	lipid biosynthetic process
A	0015629	cellular_component	actin cytoskeleton
A	0016874	molecular_function	ligase activity
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0046949	biological_process	fatty-acyl-CoA biosynthetic process
A	0051289	biological_process	protein homotetramerization
A	0055088	biological_process	lipid homeostasis
A	0071380	biological_process	cellular response to prostaglandin E stimulus
A	2001295	biological_process	malonyl-CoA biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0001650	cellular_component	fibrillar center
B	0001894	biological_process	tissue homeostasis
B	0003824	molecular_function	catalytic activity
B	0003989	molecular_function	acetyl-CoA carboxylase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006084	biological_process	acetyl-CoA metabolic process
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0006637	biological_process	acyl-CoA metabolic process
B	0008610	biological_process	lipid biosynthetic process
B	0015629	cellular_component	actin cytoskeleton
B	0016874	molecular_function	ligase activity
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0046949	biological_process	fatty-acyl-CoA biosynthetic process
B	0051289	biological_process	protein homotetramerization
B	0055088	biological_process	lipid homeostasis
B	0071380	biological_process	cellular response to prostaglandin E stimulus
B	2001295	biological_process	malonyl-CoA biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0001650	cellular_component	fibrillar center
C	0001894	biological_process	tissue homeostasis
C	0003824	molecular_function	catalytic activity
C	0003989	molecular_function	acetyl-CoA carboxylase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006084	biological_process	acetyl-CoA metabolic process
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0006637	biological_process	acyl-CoA metabolic process
C	0008610	biological_process	lipid biosynthetic process
C	0015629	cellular_component	actin cytoskeleton
C	0016874	molecular_function	ligase activity
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0046949	biological_process	fatty-acyl-CoA biosynthetic process
C	0051289	biological_process	protein homotetramerization
C	0055088	biological_process	lipid homeostasis
C	0071380	biological_process	cellular response to prostaglandin E stimulus
C	2001295	biological_process	malonyl-CoA biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0001650	cellular_component	fibrillar center
D	0001894	biological_process	tissue homeostasis
D	0003824	molecular_function	catalytic activity
D	0003989	molecular_function	acetyl-CoA carboxylase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006084	biological_process	acetyl-CoA metabolic process
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0006637	biological_process	acyl-CoA metabolic process
D	0008610	biological_process	lipid biosynthetic process
D	0015629	cellular_component	actin cytoskeleton
D	0016874	molecular_function	ligase activity
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0046949	biological_process	fatty-acyl-CoA biosynthetic process
D	0051289	biological_process	protein homotetramerization
D	0055088	biological_process	lipid homeostasis
D	0071380	biological_process	cellular response to prostaglandin E stimulus
D	2001295	biological_process	malonyl-CoA biosynthetic process
E	0000166	molecular_function	nucleotide binding
E	0001650	cellular_component	fibrillar center
E	0001894	biological_process	tissue homeostasis
E	0003824	molecular_function	catalytic activity
E	0003989	molecular_function	acetyl-CoA carboxylase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0006084	biological_process	acetyl-CoA metabolic process
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0006637	biological_process	acyl-CoA metabolic process
E	0008610	biological_process	lipid biosynthetic process
E	0015629	cellular_component	actin cytoskeleton
E	0016874	molecular_function	ligase activity
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0046949	biological_process	fatty-acyl-CoA biosynthetic process
E	0051289	biological_process	protein homotetramerization
E	0055088	biological_process	lipid homeostasis
E	0071380	biological_process	cellular response to prostaglandin E stimulus
E	2001295	biological_process	malonyl-CoA biosynthetic process
F	0000166	molecular_function	nucleotide binding
F	0001650	cellular_component	fibrillar center
F	0001894	biological_process	tissue homeostasis
F	0003824	molecular_function	catalytic activity
F	0003989	molecular_function	acetyl-CoA carboxylase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0006084	biological_process	acetyl-CoA metabolic process
F	0006629	biological_process	lipid metabolic process
F	0006631	biological_process	fatty acid metabolic process
F	0006633	biological_process	fatty acid biosynthetic process
F	0006637	biological_process	acyl-CoA metabolic process
F	0008610	biological_process	lipid biosynthetic process
F	0015629	cellular_component	actin cytoskeleton
F	0016874	molecular_function	ligase activity
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
F	0046949	biological_process	fatty-acyl-CoA biosynthetic process
F	0051289	biological_process	protein homotetramerization
F	0055088	biological_process	lipid homeostasis
F	0071380	biological_process	cellular response to prostaglandin E stimulus
F	2001295	biological_process	malonyl-CoA biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00188
Number of Residues	18
Details	BIOTIN Biotin-requiring enzymes attachment site. GQcYaeIeVMKMvmtLtA

Chain	Residue	Details
D	GLY776-ALA793

---

site_id	PS00866
Number of Residues	15
Details	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. YPVMIKASeggGGkG

Chain	Residue	Details
D	TYR306-GLY320

---

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. FLELNPRL

Chain	Residue	Details
D	PHE435-LEU442

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1352
Details	Domain: {"description":"CoA carboxyltransferase N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU01136","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1264
Details	Domain: {"description":"CoA carboxyltransferase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU01137","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2632
Details	Region: {"description":"Carboxyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01138","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---