6G1K

Electron cryo-microscopy structure of the canonical TRPC4 ion channel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0006816	biological_process	calcium ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0006816	biological_process	calcium ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006812	biological_process	monoatomic cation transport
C	0006816	biological_process	calcium ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006812	biological_process	monoatomic cation transport
D	0006816	biological_process	calcium ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0046872	molecular_function	metal ion binding
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue Y01 A 1001

Chain	Residue
A	TYR315
A	LEU495
A	PHE496
A	ALA498
B	LEU528

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site_id	AC2
Number of Residues	7
Details	binding site for residue 44E A 1002

Chain	Residue
B	ALA598
B	THR599
B	THR603
A	GLN569
A	PHE572
A	TRP573
B	PHE595

---

site_id	AC3
Number of Residues	5
Details	binding site for residue Y01 B 1001

Chain	Residue
B	TYR315
B	LEU495
B	PHE496
B	ALA498
D	LEU528

---

site_id	AC4
Number of Residues	7
Details	binding site for residue 44E B 1002

Chain	Residue
B	GLN569
B	PHE572
B	TRP573
D	PHE595
D	ALA598
D	THR599
D	THR603

---

site_id	AC5
Number of Residues	5
Details	binding site for residue Y01 C 1001

Chain	Residue
A	LEU528
C	TYR315
C	LEU495
C	PHE496
C	ALA498

---

site_id	AC6
Number of Residues	7
Details	binding site for residue 44E C 1002

Chain	Residue
A	PHE595
A	ALA598
A	THR599
A	THR603
C	GLN569
C	PHE572
C	TRP573

---

site_id	AC7
Number of Residues	5
Details	binding site for residue Y01 D 1001

Chain	Residue
C	LEU528
D	TYR315
D	LEU495
D	PHE496
D	ALA498

---

site_id	AC8
Number of Residues	7
Details	binding site for residue 44E D 1002

Chain	Residue
C	PHE595
C	ALA598
C	THR599
C	THR603
D	GLN569
D	PHE572
D	TRP573

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Functional Information from PROSITE/UniProt

site_id	PS00962
Number of Residues	12
Details	RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. LiSLFTANSHLG

Chain	Residue	Details
A	LEU492-GLY503

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