6G1K
Electron cryo-microscopy structure of the canonical TRPC4 ion channel
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0016020 | cellular_component | membrane |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0005261 | molecular_function | monoatomic cation channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0016020 | cellular_component | membrane |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0005261 | molecular_function | monoatomic cation channel activity |
| C | 0005262 | molecular_function | calcium channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006812 | biological_process | monoatomic cation transport |
| C | 0016020 | cellular_component | membrane |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
| D | 0005261 | molecular_function | monoatomic cation channel activity |
| D | 0005262 | molecular_function | calcium channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006812 | biological_process | monoatomic cation transport |
| D | 0016020 | cellular_component | membrane |
| D | 0070588 | biological_process | calcium ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue Y01 A 1001 |
| Chain | Residue |
| A | TYR315 |
| A | LEU495 |
| A | PHE496 |
| A | ALA498 |
| B | LEU528 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue 44E A 1002 |
| Chain | Residue |
| B | ALA598 |
| B | THR599 |
| B | THR603 |
| A | GLN569 |
| A | PHE572 |
| A | TRP573 |
| B | PHE595 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue Y01 B 1001 |
| Chain | Residue |
| B | TYR315 |
| B | LEU495 |
| B | PHE496 |
| B | ALA498 |
| D | LEU528 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue 44E B 1002 |
| Chain | Residue |
| B | GLN569 |
| B | PHE572 |
| B | TRP573 |
| D | PHE595 |
| D | ALA598 |
| D | THR599 |
| D | THR603 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue Y01 C 1001 |
| Chain | Residue |
| A | LEU528 |
| C | TYR315 |
| C | LEU495 |
| C | PHE496 |
| C | ALA498 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue 44E C 1002 |
| Chain | Residue |
| A | PHE595 |
| A | ALA598 |
| A | THR599 |
| A | THR603 |
| C | GLN569 |
| C | PHE572 |
| C | TRP573 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue Y01 D 1001 |
| Chain | Residue |
| C | LEU528 |
| D | TYR315 |
| D | LEU495 |
| D | PHE496 |
| D | ALA498 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue 44E D 1002 |
| Chain | Residue |
| C | PHE595 |
| C | ALA598 |
| C | THR599 |
| C | THR603 |
| D | GLN569 |
| D | PHE572 |
| D | TRP573 |
Functional Information from PROSITE/UniProt
| site_id | PS00962 |
| Number of Residues | 12 |
| Details | RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. LiSLFTANSHLG |
| Chain | Residue | Details |
| A | LEU492-GLY503 |
