6G0A
The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0006260 | biological_process | DNA replication |
| A | 0006281 | biological_process | DNA repair |
| A | 0008622 | cellular_component | epsilon DNA polymerase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue DTP A 1301 |
| Chain | Residue |
| A | ASP640 |
| A | CA1302 |
| A | HOH1406 |
| P | DOC11 |
| T | DT5 |
| T | DG6 |
| A | VAL641 |
| A | SER643 |
| A | MET644 |
| A | TYR645 |
| A | ARG781 |
| A | LYS824 |
| A | ASN828 |
| A | ASP877 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 1302 |
| Chain | Residue |
| A | ASP640 |
| A | VAL641 |
| A | ASP877 |
| A | DTP1301 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 1303 |
| Chain | Residue |
| A | ASP290 |
| A | GLU292 |
| A | ASP477 |
| A | HOH1411 |
| A | HOH1412 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue FE A 1304 |
| Chain | Residue |
| A | CYS677 |
| A | CYS763 |
