6FVM
Mutant DNA polymerase sliding clamp from Escherichia coli with bound P7 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006260 | biological_process | DNA replication |
| A | 0006261 | biological_process | DNA-templated DNA replication |
| A | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0009360 | cellular_component | DNA polymerase III complex |
| A | 0030174 | biological_process | regulation of DNA-templated DNA replication initiation |
| A | 0030894 | cellular_component | replisome |
| A | 0032297 | biological_process | negative regulation of DNA-templated DNA replication initiation |
| A | 0042276 | biological_process | error-prone translesion synthesis |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0044787 | biological_process | bacterial-type DNA replication |
| A | 1990078 | cellular_component | replication inhibiting complex |
| A | 1990085 | cellular_component | Hda-beta clamp complex |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006260 | biological_process | DNA replication |
| B | 0006261 | biological_process | DNA-templated DNA replication |
| B | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0009360 | cellular_component | DNA polymerase III complex |
| B | 0030174 | biological_process | regulation of DNA-templated DNA replication initiation |
| B | 0030894 | cellular_component | replisome |
| B | 0032297 | biological_process | negative regulation of DNA-templated DNA replication initiation |
| B | 0042276 | biological_process | error-prone translesion synthesis |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0044787 | biological_process | bacterial-type DNA replication |
| B | 1990078 | cellular_component | replication inhibiting complex |
| B | 1990085 | cellular_component | Hda-beta clamp complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 401 |
| Chain | Residue |
| A | GLU6 |
| A | HIS9 |
| A | GLN61 |
| A | HOH542 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue 1PE A 402 |
| Chain | Residue |
| A | ARG80 |
| A | LEU82 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE A 403 |
| Chain | Residue |
| A | ALA58 |
| A | VAL60 |
| A | ASP229 |
| A | HIS9 |
| A | PRO28 |
| A | ARG56 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE A 404 |
| Chain | Residue |
| A | SER18 |
| A | LEU21 |
| A | GLY22 |
| A | ARG73 |
| A | PHE76 |
| A | HOH605 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue 1PE A 405 |
| Chain | Residue |
| A | TYR284 |
| A | LYS291 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 406 |
| Chain | Residue |
| A | SER192 |
| A | ILE194 |
| A | GLY239 |
| A | PHE241 |
| A | HOH525 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue 1PE B 401 |
| Chain | Residue |
| B | SER18 |
| B | LEU21 |
| B | GLY23 |
| B | ARG73 |
| B | PHE76 |
| B | ARG80 |
| B | HOH505 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue 1PE B 402 |
| Chain | Residue |
| B | GLU161 |
| B | SER190 |
| B | ARG245 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE B 403 |
| Chain | Residue |
| B | HIS9 |
| B | ARG56 |
| B | ALA58 |
| B | VAL60 |
| B | ASP229 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE B 404 |
| Chain | Residue |
| A | PRO297 |
| A | HOH672 |
| B | PRO83 |
| B | GLU84 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue 1PE B 405 |
| Chain | Residue |
| B | SER192 |
| B | GLY239 |
| B | ARG240 |
| B | PHE241 |
| B | PRO242 |
| B | ASP243 |
| B | HOH512 |
| B | HOH562 |
| site_id | AD3 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide ACE H 1 and GLN H 2 |
| Chain | Residue |
| A | HIS175 |
| A | TYR323 |
| A | GLU334 |
| A | ASN335 |
| A | ALA353 |
| A | MET362 |
| A | PRO363 |
| A | MET364 |
| A | ARG365 |
| A | HOH501 |
| A | HOH520 |
| A | HOH555 |
| H | ALC3 |
| site_id | AD4 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide GLN H 2 and ALC H 3 |
| Chain | Residue |
| A | HIS175 |
| A | TYR323 |
| A | ALA353 |
| A | MET362 |
| A | PRO363 |
| A | MET364 |
| A | ARG365 |
| A | HOH501 |
| A | HOH520 |
| A | HOH555 |
| H | ACE1 |
| H | ASP4 |
| site_id | AD5 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide ALC H 3 and ASP H 4 |
| Chain | Residue |
| A | GLY174 |
| A | HIS175 |
| A | ALA353 |
| A | MET362 |
| A | PRO363 |
| A | ARG365 |
| H | ACE1 |
| H | GLN2 |
| H | LEU5 |
| H | PHE6 |
| H | HOH101 |
| site_id | AD6 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide ACE I 1 and GLN I 2 |
| Chain | Residue |
| I | HOH105 |
| I | HOH106 |
| B | HIS175 |
| B | TYR323 |
| B | GLU334 |
| B | ASN335 |
| B | MET362 |
| B | PRO363 |
| B | MET364 |
| B | ARG365 |
| I | ALC3 |
| I | HOH102 |
| I | HOH103 |
| site_id | AD7 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide GLN I 2 and ALC I 3 |
| Chain | Residue |
| B | HIS175 |
| B | TYR323 |
| B | GLU334 |
| B | ASN335 |
| B | MET362 |
| B | PRO363 |
| B | MET364 |
| B | ARG365 |
| I | ACE1 |
| I | ASP4 |
| I | HOH102 |
| I | HOH103 |
| I | HOH105 |
| I | HOH106 |
| site_id | AD8 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide ALC I 3 and ASP I 4 |
| Chain | Residue |
| B | GLU334 |
| B | ASN335 |
| B | MET362 |
| B | PRO363 |
| B | ARG365 |
| B | HOH580 |
| I | ACE1 |
| I | GLN2 |
| I | LEU5 |
| I | PHE6 |
| I | HOH104 |
| I | HOH107 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:18191219 |
| Chain | Residue | Details |
| A | ARG24 | |
| A | GLN149 | |
| A | TYR153 | |
| B | ARG24 | |
| B | GLN149 | |
| B | TYR153 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18191219 |
| Chain | Residue | Details |
| A | ARG73 | |
| B | ARG73 |
